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Cited by 56Stress Responses and CortisolNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Long-Term Behavioral Programming Induced by Peripuberty Stress in Rats Is Accompanied by GABAergic-Related Alterations in the Amygdala

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Tzanoulinou, Stamatina, García-Mompó, Clara, Castillo-Gómez, Esther, Veenit, Vandana, Nacher, Juan, Sandi, Carmen·2014·PLoS ONE
DOI 10.1371/journal.pone.0094666PMC PMC3988094
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Abstract

Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often implicated in anxiety and mood disorders. Abnormal amygdala functioning has also been detected following stress exposure and is also implicated in anxiety and social disorders. However, the amygdala is not a unitary structure; it includes several nuclei with different functions and little is known on the potential differences the impact of early life stress may have on this system within different amygdaloid nuclei. We aimed here to evaluate potential regional differences in the expression of GABAergic-related markers across several amygdaloid nuclei in adult rats subjected to a peripuberty stress protocol that leads to enhanced basal amygdala activity and psychopathological behaviors. More specifically, we investigated the protein expression levels of glutamic acid decarboxylase (GAD; the principal synthesizing enzyme of GABA) and of GABA-A receptor subunits α2 and α3. We found reduced GAD and GABA-A α3, but not α2, subunit protein levels throughout all the amygdala nuclei examined (lateral, basolateral, basomedial, medial and central) and increased anxiety-like behaviors and reduced sociability in peripubertally stressed animals. Our results identify an enduring inhibition of the GABAergic system across the amygdala following exposure to early adversity. They also highlight the suitability of the peripuberty stress model to investigate the link between treatments targeting the dysfunctional GABAergic system in specific amygdala nuclei and recovery of specific stress-induced behavioral dysfunctions.

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Authors
Tzanoulinou, S., García-Mompó, C., Castillo-Gómez, E., Veenit, V., Nacher, J., & Sandi, C.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • Universitat de València (ES)
Corresponding author
Sandi, Carmen
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-04-15
Volume
9
Issue
4
Pages
e94666
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0094666
PMC
PMC3988094
OpenAlex
W2050717527
Cited by
56
References
115
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 2
FWCI
3.11
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • National Science Foundation
  • École Polytechnique Fédérale de Lausanne (31003AB-135710)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (32512, 135710)
  • Ministerio de Economía y Competitividad (BFU2012-32512)
  • Generalitat Valenciana (PROMETEO2013/069, ACOMP/2012/229)
  • Ministerio de Ciencia e Innovación (BFU2012-32512)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
early life stress, GABAergic system, amygdala nuclei, glutamic acid decarboxylase, GABAA receptor subunits, anxiety-like behavior, sociability, childhood adversity
MeSH terms
Amygdala, Animals, Anxiety, Behavior, Animal, Body Weight, Exploratory Behavior, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Interpersonal Relations, Puberty, Receptors, GABA-A, Stress, Psychological, Rats, Wistar, Rats

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