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Cited by 37Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAlzheimer's disease research and treatments

Gray and White Matter Changes in Subjective Cognitive Impairment, Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Voxel-Based Analysis Study

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Kiuchi, Kuniaki, Kitamura, Soichiro, Taoka, Toshiaki, Yasuno, Fumihiko, Tanimura, Masami, Matsuoka, Kiwamu, Ikawa, Daisuke, Toritsuka, Michihiro +6 more·2014·PLoS ONE
DOI 10.1371/journal.pone.0104007PMC PMC4122459
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Abstract

Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease.

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  • In individuals with SCD, significantly decreased FA and increased MD have been observed in the cerebrum, mainly in the hippocampal body, entorhinal cortex and parahippocampal gyrus, uncinated fasciculi, longitudinal fasciculi and corpus callosum, whereas some studies reported no statistically significant differences in diffusion metrics.

    “In individuals with SCD, significantly decreased FA and increased MD have been observed in the cerebrum, mainly in the hippocampal body, entorhinal cortex and parahippocampal gyrus, uncinated fasciculi, longitudinal fasciculi and corpus callosum [77, 78, 109–113], whereas Kiuchi et al. and Viviano et al. reported no statistically significant differences in diffusion metrics [114, 115].”

    From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [114]

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Authors
Kiuchi, K., Kitamura, S., Taoka, T., Yasuno, F., Tanimura, M., Matsuoka, K., Ikawa, D., Toritsuka, M., Hashimoto, K., Makinodan, M., Kosaka, J., Morikawa, M., Kichikawa, K., & Kishimoto, T.
Affiliations
  • Sakai City Medical Center (JP)
  • National Institute of Radiological Sciences (JP)
  • Nara Medical University (JP)
  • Doshisha University (JP)
  • Mie Prefectural Government (JP)
Corresponding author
Kiuchi, Kuniaki
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-08-05
Volume
9
Issue
8
Pages
e104007
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0104007
PMC
PMC4122459
OpenAlex
W2042561938
Cited by
37
References
3
Citations by year
2025: 1 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1
FWCI
1.53
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
Japan Society for the Promotion of Science (22791138)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
subjective cognitive impairment, amnestic mild cognitive impairment, Alzheimer's disease, gray matter changes, white matter changes, brain atrophy, diffusion tensor imaging, voxel-based morphometry, early pathological changes, dementia continuum, dynamic biomarkers
MeSH terms
Aged, Alzheimer Disease, Amnesia, Atrophy, Demography, Female, Humans, Magnetic Resonance Imaging, Male, Anisotropy, Cognitive Dysfunction, White Matter, Gray Matter

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