The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Non-Hodgkin Lymphoma Risk and Insecticide, Fungicide and Fumigant Use in the Agricultural Health Study
Open accessAbstract
Farming and pesticide use have previously been linked to non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). We evaluated agricultural use of specific insecticides, fungicides, and fumigants and risk of NHL and NHL-subtypes (including CLL and MM) in a U.S.-based prospective cohort of farmers and commercial pesticide applicators. A total of 523 cases occurred among 54,306 pesticide applicators from enrollment (1993-97) through December 31, 2011 in Iowa, and December 31, 2010 in North Carolina. Information on pesticide use, other agricultural exposures and other factors was obtained from questionnaires at enrollment and at follow-up approximately five years later (1999-2005). Information from questionnaires, monitoring, and the literature were used to create lifetime-days and intensity-weighted lifetime days of pesticide use, taking into account exposure-modifying factors. Poisson and polytomous models were used to calculate relative risks (RR) and 95% confidence intervals (CI) to evaluate associations between 26 pesticides and NHL and five NHL-subtypes, while adjusting for potential confounding factors. For total NHL, statistically significant positive exposure-response trends were seen with lindane and DDT. Terbufos was associated with total NHL in ever/never comparisons only. In subtype analyses, terbufos and DDT were associated with small cell lymphoma/chronic lymphocytic leukemia/marginal cell lymphoma, lindane and diazinon with follicular lymphoma, and permethrin with MM. However, tests of homogeneity did not show significant differences in exposure-response among NHL-subtypes for any pesticide. Because 26 pesticides were evaluated for their association with NHL and its subtypes, some chance finding could have occurred. Our results showed pesticides from different chemical and functional classes were associated with an excess risk of NHL and NHL subtypes, but not all members of any single class of pesticides were associated with an elevated risk of NHL or NHL subtypes. These findings are among the first to suggest links between DDT, lindane, permethrin, diazinon and terbufos with NHL subtypes.
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Morton, L. M., Turner, J. J., Cerhan, J. R., Linet, M. S., Treseler, P. A., Clarke, C. A., Jack, A., Cozen, W., Maynadié, M., Spinelli, J. J., et al. (2007) · Blood · doi:10.1182/blood-2006-11-051672 · Cited by 387
Cited by
Pesticides: an update of human exposure and toxicity
Mostafalou, S., & Abdollahi, M. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1849-x · Cited by 786
Glyphosate Use and Cancer Incidence in the Agricultural Health Study
Andreotti, G., Koutros, S., Hofmann, J. N., Sandler, D. P., Lubin, J. H., Lynch, C. F., Lerro, C. C., De Roos, A. J., Parks, C. G., Alavanja, M. C., et al. (2018) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djx233 · Cited by 292
Self-citationCarcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid
Loomis, D., Guyton, K., Grosse, Y., El Ghissasi, F., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Mattock, H., & Straif, K. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00081-9 · Cited by 276
Metadata
- Authors
- Alavanja, M. C. R., Hofmann, J. N., Lynch, C. F., Hines, C. J., Barry, K. H., Barker, J., Buckman, D. W., Thomas, K., Sandler, D. P., Hoppin, J. A., Koutros, S., Andreotti, G., Lubin, J. H., Blair, A., & Beane Freeman, L. E.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-10-22
- Volume
- 9
- Issue
- 10
- Pages
- e109332
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2010940201
- Cited by
- 162
- References
- 1
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Non-Hodgkin Lymphoma Risk and Insecticide, Fungicide and Fumigant Use in the Agricultural Health Study. https://app.cochat.ai/papers/10.1371/journal.pone.0109332
- The paper
- Alavanja, M. C. R., Hofmann, J. N., Lynch, C. F., Hines, C. J., Barry, K. H., Barker, J., Buckman, D. W., Thomas, K., Sandler, D. P., Hoppin, J. A., Koutros, S., Andreotti, G., Lubin, J. H., Blair, A., & Beane Freeman, L. E. (2014). Non-Hodgkin Lymphoma Risk and Insecticide, Fungicide and Fumigant Use in the Agricultural Health Study. PLoS ONE. https://doi.org/10.1371/journal.pone.0109332
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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