A longitudinal study: changes in cortical thickness and surface area during pubertal maturation
Open accessAbstract
Sex hormones have been shown to contribute to the organization and function of the brain during puberty and adolescence. Moreover, it has been suggested that distinct hormone changes in girls versus boys may contribute to the emergence of sex differences in internalizing and externalizing behavior during adolescence. In the current longitudinal study, the influence of within-subject changes in puberty (physical and hormonal) on cortical thickness and surface area was examined across a 2-year span, while controlling for age. Greater increases in Tanner Stage predicted less superior frontal thinning and decreases in precuneus surface area in both sexes. Significant Tanner Stage and sex interactions were also seen, with less right superior temporal thinning in girls but not boys, as well as greater decreases in the right bank of the superior temporal sulcus surface area in boys compared to girls. In addition, within-subject changes in testosterone over the 2-year follow-up period were found to relate to decreases in middle superior frontal surface area in boys, but increases in surface area in girls. Lastly, larger increases in estradiol in girls predicted greater middle temporal lobe thinning. These results show that within-subject physical and hormonal markers of puberty relate to region and sex-specific changes in cortical development across adolescence.
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Changes in salivary estradiol and testosterone across this time interacted with sex to predict cortical thickness changes in some of these regions.
“Further, changes in salivary estradiol and testosterone across this time interacted with sex to predict cortical thickness changes in some of these regions (Herting et al., 2015).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Herting et al., 2015
In a longitudinal study, there were effects of rate of change in pubertal status and sex in various subregions of the temporal, frontal, and occipital cortices.
“For example, in a longitudinal study in which adolescent girls and boys were scanned once during early puberty and a second time during late puberty, there were effects of rate of change in pubertal status and sex in various subregions of the temporal, frontal, and occipital cortices (Herting et al., 2015).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Herting et al., 2015
In humans, there are significant changes in gray matter volume in associative cortices around the time of puberty.
“In humans, there are significant changes in gray matter volume in associative cortices around the time of puberty (Giedd et al., 2006; Peper et al., 2009b; Herting et al., 2015).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Herting et al., 2015
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References 54 · Cited by 142
- Authors
- Herting, M. M., Gautam, P., Spielberg, J. M., Dahl, R. E., & Sowell, E. R.
- Affiliations
- Children's Hospital Los Angeles (US)
- VA Boston Healthcare System (US)
- University of California, Berkeley (US)
- Corresponding author
- Herting, Megan M.
- Sowell, Elizabeth R.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-20
- Volume
- 10
- Issue
- 3
- Pages
- e0119774
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4368209
- OpenAlex
- W2018463951
- Cited by
- 142
- References
- 54
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 10 · 2023: 16 · 2022: 7 · 2021: 8 · 2020: 17 · 2019: 10 · 2018: 20 · 2017: 19 · 2016: 13 · 2015: 2
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (MH087563, R01MH087563)
- National Institute on Drug Abuse (R01DA018910)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD078084)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- puberty, cortical thickness, cortical surface area, cortical thinning, sex differences, sex hormones, testosterone, estradiol, Tanner stages, adolescence, superior frontal cortex, precuneus, superior temporal sulcus, middle temporal lobe, brain development
- MeSH terms
- Adolescent, Cerebral Cortex, Child, Estradiol, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Puberty, Testosterone
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