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An IL-13 Promoter Polymorphism Associated with Liver Fibrosis in Patients with Schistosoma japonicum

Long, Xin, Chen, Qian, Zhao, Jianping, Rafaels, Nicholas, Mathias, Priyanka, Liang, Huifang, Potee, Joseph, Campbell, Monica, Zhang, Bixiang, Gao, Li, Georas, Steve N., Vercelli, Donata, Beaty, Terri H., Ruczinski, Ingo, Mathias, Rasika, Barnes, Kathleen C., Chen, Xiaoping·2015·PLOS ONE
DOI 10.1371/journal.pone.0135360PMC PMC4530950
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Fig 1 Pairwise linkage disequilibrium (LD) of 2SNPS in IL13 gene.
Fig 1 Pairwise linkage disequilibrium (LD) of 2SNPS in IL13 gene.CC BY · PubMed Central
Fig 2 IL-13 protein was determined by IHC and western blot. (A) Representative images of normal liver tissues and S.japonicum-induced fibrotic liver tissues (Images were captured at 100x and 400x with scale bar of 100 μm). (B) Comparison of scores of ST2 staining intensity betwee S. japonicum-induced fibrotic liver tissues and normal liver tissues. (C) IL-13 protein was detected in liver tissue lysates by western blots.
Fig 2 IL-13 protein was determined by IHC and western blot. (A) Representative images of normal liver tissues and S.japonicum-induced fibrotic liver tissues (Images were captured at 100x and 400x with scale bar of 100 μm). (B) Comparison of scores of ST2 staining intensity betwee S. japonicum-induced fibrotic liver tissues and normal liver tissues. (C) IL-13 protein was detected in liver tissue lysates by western blots.CC BY · PubMed Central
Fig 3 Relative luciferase activity of plasmid construct of PGL4.17-rs1800925T and PGL4.17-rs1800925C in 293FT, QSG-7701 and HL-7702 cell lines. (A) Complementary base sequence of target DNA in plasmid PGL4.17-rs1800925C. (B) Complementary base sequence of target DNA in plasmid PGL4.17-rs1800925T constructed by overlap PCR. (C) Relative luciferase activity of plasmid construct of PGL4.17-rs1800925T and PGL4.17-rs1800925C in 293FT, QSG-7701 and HL-7702 cell lines. (Rs1800925C indicates plasmid PGL4.17-rs1800925C and rs1800925T indicates plasmid PGL4.17-rs1800925T).
Fig 3 Relative luciferase activity of plasmid construct of PGL4.17-rs1800925T and PGL4.17-rs1800925C in 293FT, QSG-7701 and HL-7702 cell lines. (A) Complementary base sequence of target DNA in plasmid PGL4.17-rs1800925C. (B) Complementary base sequence of target DNA in plasmid PGL4.17-rs1800925T constructed by overlap PCR. (C) Relative luciferase activity of plasmid construct of PGL4.17-rs1800925T and PGL4.17-rs1800925C in 293FT, QSG-7701 and HL-7702 cell lines. (Rs1800925C indicates plasmid PGL4.17-rs1800925C and rs1800925T indicates plasmid PGL4.17-rs1800925T).CC BY · PubMed Central

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Metadata

Authors
Long, X., Chen, Q., Zhao, J., Rafaels, N., Mathias, P., Liang, H., Potee, J., Campbell, M., Zhang, B., Gao, L., Georas, S. N., Vercelli, D., Beaty, T. H., Ruczinski, I., Mathias, R., Barnes, K. C., & Chen, X.
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2015-08-10
Volume
10
Issue
8
Pages
e0135360
ISSN
1932-6203
DOI
10.1371/journal.pone.0135360
PMC
PMC4530950
Cited by
28
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: An IL-13 Promoter Polymorphism Associated with Liver Fibrosis in Patients with Schistosoma japonicum. https://app.cochat.ai/papers/10.1371/journal.pone.0135360
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Long, X., Chen, Q., Zhao, J., Rafaels, N., Mathias, P., Liang, H., Potee, J., Campbell, M., Zhang, B., Gao, L., Georas, S. N., Vercelli, D., Beaty, T. H., Ruczinski, I., Mathias, R., Barnes, K. C., & Chen, X. (2015). An IL-13 Promoter Polymorphism Associated with Liver Fibrosis in Patients with Schistosoma japonicum. PLOS ONE. https://doi.org/10.1371/journal.pone.0135360