The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antidepressants and Gastric Cancer: A Nationwide Population-Based Nested Case-Control Study
Open accessAbstract
BACKGROUND: To our knowledge, no epidemiological study has reported on whether an association between antidepressant exposure and gastric cancer exists. Herein, we aim to investigate the possible association between antidepressant exposure and gastric cancer incidence. METHODS: Using a nested case-control design, we identified 26289 cases with gastric cancer and 127984 controls from Taiwan's National Health Insurance Research Database (NHIRD). The data were analyzed using a conditional logistic regression model adjusting for possible confounding variables. RESULTS: We found antidepressant use did not increase the risk of gastric cancer. The lack of an association between antidepressant prescription and elevated gastric cancer incidence was apparent for across selective serotonin-reuptake inhibitors (SSRIs), tricyclic agents (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), reversible inhibitors of monoamine oxidase A (RIMA), trazodone, mirtazapine and bupropion. There were slightly decreased gastric cancer risks of SSRIs use (≧28 DDD group, adjusted OR = 0.87; 95% CI = 0.78-0.96). Sensitive analysis showed SSRIs, TCAs, and SNRIs did not increase gastric cancer risks significantly even in the group with peptic ulcer history. CONCLUSIONS: An association between antidepressant exposure and gastric cancer was not apparent in this analysis.
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The 30-day criterion for antidepressant users is widely accepted in other studies.
“and this criterion is widely accepted in other studies [40-42].”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [42]
The Materials and Methods section (Antidepressants’ exposure; page not provided) uses a threshold of at least 28 defined daily doses, which is close to—but not the same as—a 30-day criterion. It does not say that a 30-day criterion for antidepressant users is widely accepted in other studies. (LLM, conf=0.78)
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Anglin, R., Yuan, Y., Moayyedi, P., Tse, F., Armstrong, D., & Leontiadis, G. I. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.82 · Cited by 234 · cited 1×
“The foregoing gastro-protective effects, however, need to be taken in a clinical context as replicative evidence also indicates that SSRIs exposure is associated with increased upper gastrointestinal bleeding [10, 12].”
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Then, C.-K., Chi, N.-F., Chung, K.-H., Kuo, L., Liu, K.-H., Hu, C.-J., Shen, S.-C., & Lin, Y.-K. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175187 · Cited by 35
Metadata
- Authors
- Hsieh, Y.-H., Chiu, W.-C., Lin, C.-F., Chan, H.-L., Liang, H.-Y., Lee, Y., McIntyre, R. S., & Chen, V. C.-H.
- Affiliations
- Linkou Chang Gung Memorial Hospital (TW)
- Fu Jen Catholic University (TW)
- University Health Network (CA)
- Chiayi Chang Gung Memorial Hospital (TW)
- Corresponding author
- Chen, Vincent Chin-Hung
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-11-25
- Volume
- 10
- Issue
- 11
- Pages
- e0143668
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4659600
- OpenAlex
- W2176174885
- Cited by
- 22
- References
- 1
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 6 · 2017: 3 · 2016: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- antidepressants, gastric cancer, gastric cancer incidence, selective serotonin reuptake inhibitors, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, trazodone, mirtazapine, bupropion, peptic ulcer
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antidepressive Agents, Female, Humans, Male, Middle Aged, Population Surveillance, Risk, Socioeconomic Factors, Stomach Neoplasms, Taiwan, Comorbidity, Confounding Factors, Epidemiologic, Case-Control Studies, Young Adult
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