The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis
Open accessAbstract
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease. In this study, RA patients were sub-grouped depending upon the presence or absence of rheumatoid factor, disease activity score and disease duration. RA Patients (120) and healthy controls (53) were evaluated for the oxidant-antioxidant status by monitoring ROS production, biomarkers of lipid peroxidation, protein oxidation and DNA damage. The level of various enzymatic and non-enzymatic antioxidants was also monitored. Correlation analysis was also performed for analysing the association between ROS and various other parameters. METHODS: Intracellular ROS formation, lipid peroxidation (MDA level), protein oxidation (carbonyl level and thiol level) and DNA damage were detected in the blood of RA patients. Antioxidant status was evaluated by FRAP assay, DPPH reduction assay and enzymatic (SOD, catalase, GST, GR) and non-enzymatic (vitamin C and GSH) antioxidants. RESULTS: RA patients showed a higher ROS production, increased lipid peroxidation, protein oxidation and DNA damage. A significant decline in the ferric reducing ability, DPPH radical quenching ability and the levels of antioxidants has also been observed. Significant correlation has been found between ROS and various other parameters studied. CONCLUSION: RA patients showed a marked increase in ROS formation, lipid peroxidation, protein oxidation, DNA damage and decrease in the activity of antioxidant defence system leading to oxidative stress which may contribute to tissue damage and hence to the chronicity of the disease.
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Cites
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Cited by
Wallace, T. C., Bailey, R. L., Blumberg, J. B., Burton-Freeman, B., Chen, C.-Y. O., Crowe-White, K. M., Drewnowski, A., Hooshmand, S., Johnson, E., Lewis, R., et al. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1632258 · Cited by 638
Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis
Phull, A.-R., Nasir, B., Haq, I. U., & Kim, S. J. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.12.024 · Cited by 452
Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases
Kehm, R., Baldensperger, T., Raupbach, J., & Höhn, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101901 · Cited by 348
“RA patients (n = 120) Spectrophotometry Higher protein carbonyl levels in RA patients [226]”
BackgroundGarcía-Sánchez, A., Miranda-Díaz, A. G., & Cardona-Muñoz, E. G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2082145 · Cited by 331
Srivastava, S., Saksena, A. K., Khattri, S., Kumar, S., & Dagur, R. S. (2016) · Inflammopharmacology · doi:10.1007/s10787-016-0289-9 · Cited by 143
Metadata
- Authors
- Mateen, S., Moin, S., Khan, A. Q., Zafar, A., & Fatima, N.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-04-04
- Volume
- 11
- Issue
- 4
- Pages
- e0152925
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2313462881
- Cited by
- 434
- References
- 51
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- gold
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