Cited by 198Medical Imaging and AnalysisArtificial Intelligence in Healthcare and EducationHip disorders and treatments

A preliminary examination of the diagnostic value of deep learning in hip osteoarthritis

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Xue, Yanping, Zhang, Rongguo, Deng, Yufeng, Chen, Kuan, Jiang, Tao·2017·PLOS ONE

Abstract

Hip Osteoarthritis (OA) is a common disease among the middle-aged and elderly people. Conventionally, hip OA is diagnosed by manually assessing X-ray images. This study took the hip joint as the object of observation and explored the diagnostic value of deep learning in hip osteoarthritis. A deep convolutional neural network (CNN) was trained and tested on 420 hip X-ray images to automatically diagnose hip OA. This CNN model achieved a balance of high sensitivity of 95.0% and high specificity of 90.7%, as well as an accuracy of 92.8% compared to the chief physicians. The CNN model performance is comparable to an attending physician with 10 years of experience. The results of this study indicate that deep learning has promising potential in the field of intelligent medical image diagnosis practice.

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Crossref · 10.1371/journal.pone.0178992

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References 24 · Cited by 198

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  1. [1]Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis [Internet]. 2014; 73(7): 1323– 30. doi: 10.1136/annrheumdis-2013-204763 24553908 · DOI
  2. [2]Nho SJ, Kymes SM, Callaghan JJ, Felson DT. The burden of hip osteoarthritis in the United States: epidemiologic and economic considerations. J Am Acad Orthop Surg [Internet]. 2013; 21 Suppl 1: S1– 6. 23818185
  3. [3]Radcliff K, Raphael IJ, Rasouli MR, Kepler CK, Albert TJ, Parvizi J. Pelvic Incidence in Patients with Hip Osteoarthritis. Spine J [Internet]. 2012; 12(9): S68– 9. PMC4852038 27200390
  4. [4]Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis [Internet]. 2014; 73(9): 1659– 64. doi: 10.1136/annrheumdis-2013-203355 23744977 PMC3875433 · DOI
  5. [5]Yu D, Peat G, Bedson J, Jordan KP. Annual consultation incidence of osteoarthritis estimated from population-based health care data in England. Rheumatol (United Kingdom). 2015; 54(11): 2051– 60. PMC4603278 26163287
  6. [6]Lau EMC. Hip osteoarthritis and dysplasia in Chinese men. Ann Rheum Dis. 1995; 54: 965– 9. 8546528 PMC1010061
  7. [7]Guermazi A, Hayashi D, Roemer FW, Felson DT. Osteoarthritis. A Review of Strengths and Weaknesses of Different Imaging Options. Rheum Dis Clin North Am. 2013; 39(3): 567– 91. doi: 10.1016/j.rdc.2013.02.001 23719076 · DOI
  8. [8]Roux CH, Mazieres B, Verrouil E, Rat AC, Fardellone P, Fautrel B, et al Femoro-tibial knee osteoarthritis: One or two X-rays? Results from a population-based study. Jt Bone Spine [Internet]. 2015; 83(1): 37– 42. 26520886
  9. [9]Kellgren J.H., Lawrence J. S. Radiological assessment of osteoarthritis. Ann Rheum Dis. 1957; 16: 494– 502. 13498604 PMC1006995
  10. [10]Croft P, Cooper C, Wickham C, Coggon D. Defining osteoarthritis of the hip for epidemiologic studies. Am J Epidemiol [Internet]. 1990; 132(3): 514– 22. 2389755
  11. [12]Rusk N. Deep learning. Nat Methods [Internet]. 2015; 13(1): 35– 35.
  12. [14]Ertosun M.G., Rubin DL. Automated Grading of Gliomas using Deep Learning in Digital Pathology Images: A modular approach with ensemble of convolutional neural networks. AMIA Annu Symp Proc. 2015: 1899– 908. 26958289 PMC4765616
  13. [15]Kraus OZ, Ba JL, Frey BJ. Classifying and segmenting microscopy images with deep multiple instance learning. Bioinformatics. 2016; 32(12): 152– 9. PMC4908336 27307644
  14. [16]Wang J, Yang X, Cai H, Tan W, Jin C, Li L. Discrimination of Breast Cancer with Microcalcifications on Mammography by Deep Learning. Sci Rep 2016;(2): 1– 9. PMC4895132 27273294
  15. [19]Wu G, Kim M, Wang Q, Gao Y, Liao S, Shen D. Unsupervised deep feature learning for deformable registration of MR brain images. Lect Notes Comput Sci (including Subser Lect Notes Artif Intell Lect Notes Bioinformatics). 2013; 8150 LNCS(PART 2): 649– 56. PMC4073478 24579196
  16. [21]Conrozier T, Brandt K, Piperno M, Mathieu P, Merie-Vincent F, Vignon E. Reproducibility and sensitivity to change of a new method of computer measurement of joint space width in hip osteoarthritis. Performacne of three radiographic views obtained at a 3-year interval. Osteoarthritis and Cartilage 2009; 17(7): 864– 870. doi: 10.1016/j.joca.2008.12.003 19138537 · DOI
  17. [22]Nepple JJ, Martel JM, Kim YJ, Zaltz I, Millis MB, Podeszwa DA, Sucato DJ, Sink EL, Clohisy JC. Interobserver and intraobserver reliability of the radiographic analysis of femoroacetabular impingement and dysplasis using computer-assisted measurements. The American journal of sports medicine, 2014; 42(10): 2393– 2401. doi: 10.1177/0363546514542797 25134816 · DOI

Authors
Xue, Y., Zhang, R., Deng, Y., Chen, K., & Jiang, T.
Affiliations
  • Capital Medical University (CN)
  • InferVision (China) (CN)
Corresponding author
  • Deng, Yufeng
  • Jiang, Tao
Venue
PLOS ONE
Published
2017-06-02
Volume
12
Issue
6
Pages
e0178992
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2621007086
Cited by
198
References
24
Citations by year
2026: 11 · 2025: 22 · 2024: 37 · 2023: 32 · 2022: 24 · 2021: 23 · 2020: 28 · 2019: 12 · 2018: 9
FWCI
6.03
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords
hip osteoarthritis, deep learning, convolutional neural networks, X-ray images, automated diagnosis, diagnostic accuracy, radiographic evaluation, artificial intelligence in medical imaging
MeSH terms
Hip Joint, Humans, Image Processing, Computer-Assisted, Radiography, Osteoarthritis, Hip, Neural Networks, Computer

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