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Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain

Open access
Kerrigan, Deanna, Mantsios, Andrea, Gorgolas, Miguel, Montes, Maria-Luisa, Pulido, Federico, Brinson, Cynthia, deVente, Jerome, Richmond, Gary J., Beckham, S. Wilson, Hammond, Paige, Margolis, David, Murray, Miranda·2018·PLOS ONE

Abstract

Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable LA regimen in the U.S. and Spain. Interviews exploring participant and provider attitudes and experiences with LA versus oral ART were audiotaped, transcribed and analyzed using thematic content analysis. Participants described the convenience of LA injections versus daily pills and emotional benefits such as minimized potential for HIV disclosure and eliminating the “daily reminder of living with HIV.” Providers recognized benefits but cautioned that LA candidates still need to adhere to clinic visits for injections and raised questions around ongoing clinical management. LA was seen as preferable to daily oral ART among PLHIV. Further research is needed regarding appropriate candidates, including with women and “non-adherent” populations across settings.

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Crossref · 10.1371/journal.pone.0190487

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Metadata

Authors
Kerrigan, D., Mantsios, A., Gorgolas, M., Montes, M.-L., Pulido, F., Brinson, C., deVente, J., Richmond, G. J., Beckham, S. W., Hammond, P., Margolis, D., & Murray, M.
Venue
PLOS ONE
Published
2018-01-05
Volume
13
Issue
1
Pages
e0190487
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2782437520
Cited by
174
References
4
FWCI
12.45
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain. https://app.cochat.ai/papers/10.1371/journal.pone.0190487
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Kerrigan, D., Mantsios, A., Gorgolas, M., Montes, M.-L., Pulido, F., Brinson, C., deVente, J., Richmond, G. J., Beckham, S. W., Hammond, P., Margolis, D., & Murray, M. (2018). Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain. PLOS ONE. https://doi.org/10.1371/journal.pone.0190487

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.