Telomere length in the colon is related to colorectal adenoma prevalence
Open accessAbstract
Telomere length has been associated with risk of several cancers. However, studies of the relationship between telomere length and colorectal cancer risk have been inconsistent. This study examined the relationship between telomere length in normal colon tissue and the prevalence of colorectal adenoma, a precursor to colorectal cancer. This nested case-control study consisted of 85 patients aged 40 to 65 undergoing a screening colonoscopy: 40 cases with adenoma(s) detected at colonoscopy and 45 controls with normal colonoscopy. During the colonoscopy, two pinch biopsies of healthy, normal appearing mucosa were obtained from the descending colon. Relative telomere length (rTL) was quantified in DNA extracted from colon mucosa using quantitative real-time PCR. Logistic regression was used to assess the relationship between telomere length and adenoma prevalence and estimate odds ratios and 95% confidence intervals. rTL was significantly longer in colon tissue of individuals with adenomas compared to healthy individuals (p = 0.008). When rTL was categorized into quartiles according to the distribution of rTL among controls, individuals with the longest telomeres had increased odds of adenoma when compared to individuals with shortest telomeres (OR = 4.58, 95% CI: 1.19, 17.7). This study suggests that long telomeres in normal colon tissue are associated with increased colorectal cancer risk.
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Some researchers, such as Luu et al. and Peacock et al., have reported that the risk of developing CRC seems to be higher in people with longer telomeres.
“Some researchers, such as Luu et al. [197] and Peacock et al. [198], have reported that the risk of developing CRC seems to be higher in people with longer telomeres.”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [198]
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References 75 · Cited by 14
- Authors
- Peacock, S. D., Massey, T. E., Vanner, S. J., & King, W. D.
- Affiliations
- Queen's University (CA)
- Corresponding author
- Peacock, Sarah D.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-10-17
- Volume
- 13
- Issue
- 10
- Pages
- e0205697
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6192597
- OpenAlex
- W2896077670
- Cited by
- 14
- References
- 75
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Canadian Cancer Society Research Institute (19450)
- Cancer Care Ontario
- Terry Fox Foundation Transdisciplinary Program in Cancer Research in partnership with the Canadian Institutes for Health Research
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- telomere length, colorectal adenoma, colorectal cancer risk, colonic mucosa, relative telomere length, cancer precursors, colonoscopic biopsy
- MeSH terms
- Adenoma, Adult, Biopsy, Colon, Colonoscopy, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Risk Factors, Colorectal Neoplasms, Prevalence, Case-Control Studies, Telomere, Genetic Predisposition to Disease, Real-Time Polymerase Chain Reaction, Carcinogenesis
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