Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display

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  1. Repeated Exposure to Aspergillus fumigatus Conidia Results in CD4 + T Cell-Dependent and -Independent Pulmonary Arterial Remodeling in a Mixed Th1/Th2/Th17 Microenvironment That Requires Interleukin-4 (IL-4) and IL-10
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  2. Genetic susceptibility to severe asthma with fungal sensitization
    Nicola L. D. Overton, Angela Simpson, Paul Bowyer, David W. Denning · 2017 · International Journal of Immunogenetics
  3. Aspergillus fumigatus–Induced IL-22 Is Not Restricted to a Specific Th Cell Subset and Is Dependent on Complement Receptor 3
    Mark S. Gresnigt, Katharina Becker, Sanne P. Smeekens, Cor W. M. Jacobs, Leo A. B. Joosten, Jos W. M. van der Meer, Mihai Gheorghe Netea, Frank L. van de Veerdonk · 2013 · The Journal of Immunology
  4. Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper‐reactivity and remodelling
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  5. Immunogenicity and protective efficacy of a pan-fungal vaccine in preclinical models of aspergillosis, candidiasis, and pneumocystosis
    Emily A. Rayens, Whitney Rabacal, Hubertine M. E. Willems, Gabrielle M Kirton, James P. Barber, Jarrod J. Mousa, Brandi N. Celia-Sanchez, Michelle Momany, Karen A. Norris · 2022 · PNAS Nexus
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    Chad A. Rappleye, William E. Goldman · 2007 · Trends in Immunology
  7. Pathogenesis of allergic bronchopulmonary aspergillosis in cystic fibrosis: current understanding and future directions
    Rekha R. Rapaka, Jay K. Kolls · 2008 · Medical Mycology
  8. Evolution of the Immune Response to Chronic Airway Colonization with Aspergillus fumigatus Hyphae
    Mirjam Urb, Brendan D. Snarr, Gabriella Wojewodka, Mélanie Lehoux, Mark J. Lee, Benjamin Ralph, Maziar Divangahi, Irah L. King, Toby K. McGovern, James G. Martin et al. · 2015 · Infection and Immunity
  9. Gliotoxin promotes Aspergillus fumigatus internalization into type II human pneumocyte A549 cells by inducing host phospholipase D activation
    Xiaodong Jia, Fangyan Chen, Weihua Pan, Rentao Yu, Shuguang Tian, Gaige Han, Haiqin Fang, Shuo Wang, Jingya Zhao, Xianping Li et al. · 2014 · Microbes and Infection
  10. Profile and Morphology of Fungal Aerosols Characterized by Field Emission Scanning Electron Microscopy (FESEM)
    Anani Komlavi Afanou, Anne Straumfors, Asbjørn Skogstad, Ida Skaar, Linda Gordon Hjeljord, Øivind Skare, Brett James Green, Arne Tronsmo, Wijnand Eduard · 2015 · Aerosol Science and Technology
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    Jean‐Claude Sirard, Mariela Bayardo, Arnaud M. Didierlaurent · 2006 · European Journal of Immunology
  12. Health Effects of Mold in Children
    James M. Seltzer, Marion Joseph Fedoruk · 2007 · Pediatric Clinics of North America
  13. C‐type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin‐1
    Kazuhiko Takahara, Sumika Tokieda, Koji Nagaoka, Tatsuki Takeda, Yukino Kimura, Kayo Inaba · 2011 · European Journal of Immunology
  14. Current Concepts and Controversies in Innate Immunity of Cystic Fibrosis Lung Disease
    Anjali Ralhan, Julie Laval, Felipe Lelis, Marlene Ballbach, Charlotte Grund, Andreas Hector, Dominik Hartl · 2016 · Journal of Innate Immunity
  15. Mucorales spores induce a proinflammatory cytokine response in human mononuclear phagocytes and harbor no rodlet hydrophobins
    Sebastian Wurster, Vanessa Thielen, Philipp Weis, Paul Walther, Johannes Elias, Ana Maria Waaga-Gasser, Mariola Dragan, Thomas Dandekar, Hermann Einsele, Jürgen Löffler et al. · 2017 · Virulence
  16. Dectin-1 Promotes Type I and III Interferon Expression to Support Optimal Antifungal Immunity in the Lung
    Orchi Dutta, Vanessa Espinosa, Keyi Wang, Samantha L. Avina, Amariliz Rivera · 2020 · Frontiers in Cellular and Infection Microbiology
  17. PrtT-Regulated Proteins Secreted by Aspergillus fumigatus Activate MAPK Signaling in Exposed A549 Lung Cells Leading to Necrotic Cell Death
    Haim Sharon, David Amar, Emma Levdansky, Gabriel Mircus, Yana Shadkchan, Ron Shamir A, Nir Osherov · 2011 · PLoS ONE
  18. Nanoscale biophysical properties of the cell surface galactosaminogalactan from the fungal pathogen Aspergillus fumigatus
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  19. Co-recognition of β-glucan and chitin and programming of adaptive immunity to Aspergillus fumigatus
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  20. Immunological mechanisms behind the cystic fibrosis-ABPA link
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  21. MDA5 Is an Essential Sensor of a Pathogen-Associated Molecular Pattern Associated with Vitality That Is Necessary for Host Resistance against Aspergillus fumigatus
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  22. Pattern recognition receptors and their role in invasive aspergillosis
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  23. Recognition of Candida albicans and Role of Innate Type 17 Immunity in Oral Candidiasis
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  25. Isolate-Dependent Growth, Virulence, and Cell Wall Composition in the Human Pathogen Aspergillus fumigatus
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  26. Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity
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  28. Surface availability of beta-glucans is critical determinant of host immune response to Cladosporium cladosporioides
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  29. Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome
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  30. Antibodies Generated against Conserved Antigens Expressed by Bacteria and Allergen-Bearing Fungi Suppress Airway Disease
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  31. Aspergillus spp. colonization in exhaled breath condensate of lung cancer patients from Puglia Region of Italy
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  32. Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance
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  33. Neutrophil and Eosinophil DNA Extracellular Trap Formation: Lessons From Pathogenic Fungi
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  34. Submicronic Fungal Bioaerosols: High-Resolution Microscopic Characterization and Quantification
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  35. Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish
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  36. In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography
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  37. Role of Germination in Murine Airway CD8+ T-Cell Responses to Aspergillus Conidia
    Steven P. Templeton, Amanda Dawn Buskirk, Brandon F. Law, Brett J. Green, Donald H. Beezhold · 2011 · PLoS ONE
  38. In silico modeling of spore inhalation reveals fungal persistence following low dose exposure
    Reiko J. Tanaka, Neville J. Boon, Katarina Vrcelj, Anita Nguyen, Carmelina Vinci, Darius P. H. Armstrong-James, Elaine Bignell · 2015 · Scientific Reports
  39. The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression
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  40. Genetic susceptibility to Aspergillus fumigatus infections
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  41. Primaryin vitroculture of porcine tracheal epithelial cells in an air-liquid interface as a model to study airway epithelium andAspergillus fumigatusinteractions
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  42. Evidence for the involvement of cofilin in Aspergillus fumigatus internalization into type II alveolar epithelial cells
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  43. Dectin Immunoadhesins and Pneumocystis Pneumonia
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  45. Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species
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  46. The Lung Responds to Zymosan in a Unique Manner Independent of Toll-Like Receptors, Complement, and Dectin-1
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  47. Activator protein 1 is triggered by Aspergillus fumigatus β-glucans surface-exposed during specific growth stages
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  48. Secretome of Human Bronchial Epithelial Cells in Response to the Fungal Pathogen Aspergillus fumigatus Analyzed by Differential In-Gel Electrophoresis
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  49. Conidial germination in Scedosporium apiospermum, S. aurantiacum, S. minutisporum and Lomentospora prolificans: influence of growth conditions and antifungal susceptibility profiles
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  50. Aspergillus fumigatus viability drives allergic responses to inhaled conidia
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  51. N-Glycosylation of Gel1 or Gel2 is vital for cell wall -glucan synthesis in Aspergillus fumigatus
    Wan Zhao, Yang Lü, H. Ouyang, Hua Kun Zhou, Jianghong Yan, Ting Du, C. Jin · 2013 · Glycobiology
  52. Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus
    Gregory J. Fischer, W. Clark Bacon, Jun Yang, Jonathan M. Palmer, Taylor R. T. Dagenais, Bruce D. Hammock, Nancy P. Keller · 2017 · Frontiers in Microbiology
  53. Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish
    Savini U. Thrikawala, Mengyao Niu, Nancy P. Keller, Emily E. Rosowski · 2022 · PLoS Pathogens
  54. Biochemical characterization of potential virulence markers in the human fungal pathogenPseudallescheria boydii
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  55. Innate and adaptive immune response to chronic pulmonary infection of hyphae of Aspergillus fumigatus in a new murine model
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  56. Protective effects of surfactant protein D treatment in 1,3-β-glucan-modulated allergic inflammation
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  57. Phagocytes as central players in the defence against invasive fungal infection
    Kerstin Hünniger, Oliver Kurzai · 2018 · Seminars in Cell and Developmental Biology
  58. Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection
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  59. Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis
    Isaque Medeiros Siqueira, Marcel Wüthrich, Mengyi Li, Huafeng Wang, Lucas de Oliveira Las-Casas, Raffael Júnio Araújo de Castro, Bruce S. Klein, Anamélia Lorenzetti Bocca · 2020 · PLoS neglected tropical diseases
  60. Aspergillus Fumigatus Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation through a TLR2/MyD88 Pathway
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  62. Aspergillus terreusaccessory conidia are multinucleated, hyperpolarizing structures that display differential dectin staining and can induce heightened inflammatory responses in a pulmonary model of aspergillosis
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