The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection
Open accessAbstract
The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired response. We analyzed the host response of mice deficient in the chemokine receptor CCR5 following infection with the intracellular protozoan parasite Toxoplasma gondii. We found that CCR5 controls recruitment of natural killer (NK) cells into infected tissues. Without this influx of NK cells, tissues from CCR5-deficient (CCR5-/-) mice were less able to generate an inflammatory response, had decreased chemokine and interferon gamma production, and had higher parasite burden. As a result, CCR5-/- mice were more susceptible to infection with T. gondii but were less susceptible to the immune-mediated tissue injury seen in certain inbred strains. Adoptive transfer of CCR5+/+ NK cells into CCR5-/- mice restored their ability to survive lethal T. gondii infection and demonstrated that CCR5 is required for NK cell homing into infected liver and spleen. This study establishes CCR5 as a critical receptor guiding NK cell trafficking in host defense.
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Cites
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Khan, I. A., Murphy, P. M., Casciotti, L., Schwartzman, J. D., Collins, J., Gao, J.-L., & Yeaman, G. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1930 · Cited by 88
Self-citation
Cited by
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
Griffith, J. W., Sokol, C. L., & Luster, A. D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120145 · Cited by 2,059
Self-citationThe trafficking of natural killer cells
Grégoire, C., Chasson, L., Luci, C., Tomasello, E., Geissmann, F., Vivier, E., & Walzer, T. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00563.x · Cited by 569
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
Walzer, T., Chiossone, L., Chaix, J., Calver, A., Carozzo, C., Garrigue-Antar, L., Jacques, Y., Baratin, M., Tomasello, E., & Vivier, E. (2007) · Nature Immunology · doi:10.1038/ni1523 · Cited by 431
Are some cases of psychosis caused by microbial agents? A review of the evidence
Yolken, R. H., & Torrey, E. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.5 · Cited by 329
Esté, J. A., & Telenti, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61052-6 · Cited by 287
Metadata
- Authors
- Khan, I. A., Thomas, S. Y., Moretto, M. M., Lee, F. S., Islam, S. A., Combe, C., Schwartzman, J. D., & Luster, A. D.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-06-09
- Volume
- 2
- Issue
- 6
- Pages
- e49
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2146778105
- Cited by
- 182
- References
- 2
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Khan, I. A., Thomas, S. Y., Moretto, M. M., Lee, F. S., Islam, S. A., Combe, C., Schwartzman, J. D., & Luster, A. D. (2006). CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.0020049
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