The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
Open accessAbstract
Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. However, we show here that priming Drosophila with a sublethal dose of Streptococcus pneumoniae protects against an otherwise-lethal second challenge of S. pneumoniae. This protective effect exhibits coarse specificity for S. pneumoniae and persists for the life of the fly. Although not all microbial challenges induced this specific primed response, we find that a similar specific protection can be elicited by Beauveria bassiana, a natural fly pathogen. To characterize this primed response, we focused on S. pneumoniae-induced protection. The mechanism underlying this protective effect requires phagocytes and the Toll pathway. However, activation of the Toll pathway is not sufficient for priming-induced protection. This work contradicts the paradigm that insect immune responses cannot adapt and will promote the search for similar responses overlooked in organisms with an adaptive immune response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.-M., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,043
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity
Ramirez, J. L., Garver, L. S., Brayner, F. A., Alves, L. C., Rodrigues, J., Molina-Cruz, A., & Barillas-Mury, C. (2014) · Journal of Innate Immunity · doi:10.1159/000353765 · Cited by 1,084
Lemaitre, B., Reichhart, J.-M., & Hoffmann, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14614 · Cited by 1,034
The Toll and Imd pathways are the major regulators of the immune response in Drosophila
De Gregorio, E. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2568 · Cited by 934
Michel, T., Reichhart, J.-M., Hoffmann, J. A., & Royet, J. (2001) · Nature · doi:10.1038/414756a · Cited by 796
Lemaitre, B., Kromer-Metzger, E., Michaut, L., Nicolas, E., Meister, M., Georgel, P., Reichhart, J. M., & Hoffmann, J. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9465 · Cited by 646
Sequential Activation of Signaling Pathways during Innate Immune Responses in Drosophila
Boutros, M., Agaisse, H., & Perrimon, N. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00325-8 · Cited by 516
Insect Immunity Shows Specificity in Protection upon Secondary Pathogen Exposure
Sadd, B. M., & Schmid-Hempel, P. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.047 · Cited by 450
Kaneko, T., Yano, T., Aggarwal, K., Lim, J.-H., Ueda, K., Oshima, Y., Peach, C., Erturk-Hasdemir, D., Goldman, W. E., Oh, B.-H., et al. (2006) · Nature Immunology · doi:10.1038/ni1356 · Cited by 420
Cited by
The gut microbiota of insects – diversity in structure and function
Engel, P., & Moran, N. A. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12025 · Cited by 2,595
Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728
Quintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L., Jansen, T., Kullberg, B.-J., Wijmenga, C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.006 · Cited by 1,289
Pyogenic Bacterial Infections in Humans with MyD88 Deficiency
von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C.-L., Chrabieh, M., Mustapha, I. B., Ghandil, P., Camcioglu, Y., et al. (2008) · Science · doi:10.1126/science.1158298 · Cited by 1,287
Chandler, J. A., Morgan Lang, J., Bhatnagar, S., Eisen, J. A., & Kopp, A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002272 · Cited by 766
Metadata
- Authors
- Pham, L. N., Dionne, M. S., Shirasu-Hiza, M., & Schneider, D. S.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-03-09
- Volume
- 3
- Issue
- 3
- Pages
- e26
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2009604662
- Cited by
- 571
- References
- 29
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes. https://app.cochat.ai/papers/10.1371/journal.ppat.0030026
- The paper
- Pham, L. N., Dionne, M. S., Shirasu-Hiza, M., & Schneider, D. S. (2007). A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.0030026
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
