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Engineered Anopheles Immunity to Plasmodium Infection
Open accessAbstract
A causative agent of human malaria, Plasmodium falciparum, is transmitted by Anopheles mosquitoes. The malaria parasite is under intensive attack from the mosquito's innate immune system during its sporogonic development. We have used genetic engineering to create immune-enhanced Anopheles stephensi mosquitoes through blood meal-inducible expression of a transgene encoding the IMD pathway-controlled NF-kB Rel2 transcription factor in the midgut and fat-body tissue. Transgenic mosquitoes showed greater resistance to Plasmodium and microbial infection as a result of timely concerted tissue-specific immune attacks involving multiple effectors. The relatively weak impact of this genetic modification on mosquito fitness under laboratory conditions encourages further investigation of this approach for malaria control.
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References 57 · Cited by 188
Metadata
- Authors
- Dong, Y., Das, S., Cirimotich, C., Souza-Neto, J. A., McLean, K. J., & Dimopoulos, G.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-12-22
- Volume
- 7
- Issue
- 12
- Pages
- e1002458
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2076721712
- Cited by
- 188
- References
- 57
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dong, Y., Das, S., Cirimotich, C., Souza-Neto, J. A., McLean, K. J., & Dimopoulos, G. (2011). Engineered Anopheles Immunity to Plasmodium Infection. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1002458
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
