Lipid Body–Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy?
Open accessAbstract
Phagocytosis of invading microorganisms by specialized cells such as macrophages and neutrophils is a key component of the innate immune response. These cells capture and engulf pathogens and subsequently destroy them in intracellular vacuoles-the phagosomes. Pathogen phagocytosis and progression and maturation of pathogen-containing phagosomes, a crucial event to acquire microbicidal features, occurs in parallel with accentuated formation of lipid-rich organelles, termed lipid bodies (LBs), or lipid droplets. Experimental and clinical infections with different pathogens such as bacteria, parasites, and viruses induce LB accumulation in cells from the immune system. Within these cells, LBs synthesize and store inflammatory mediators and are considered structural markers of inflammation. In addition to LB accumulation, interaction of these organelles with pathogen-containing phagosomes has increasingly been recognized in response to infections and may have implications in the outcome or survival of the microorganism within host cells. In this review, we summarize our current knowledge on the LB-phagosome interaction within cells from the immune system, with emphasis on macrophages, and discuss the functional meaning of this event during infectious diseases.
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Bacteria-containing phagosomes interact with lipid storage compartments, i.e. lipid bodies.
“Bacteria-containing phagosomes not only interact with vesicles of various origins during biogenesis but also with lipid storage compartments, i.e. lipid bodies (or droplets) (49).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [49]
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References 72 · Cited by 139
- Authors
- Melo, R. C. N., & Dvorak, A. M.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Corresponding author
- Melo, Rossana C. N.
- ORCID
- Melo, Rossana C. N.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-07-05
- Volume
- 8
- Issue
- 7
- Pages
- e1002729
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC3390411
- OpenAlex
- W2102382814
- Cited by
- 139
- References
- 72
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 13 · 2023: 18 · 2022: 6 · 2021: 10 · 2020: 13 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 10 · 2015: 10 · 2014: 14 · 2013: 7 · 2012: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Beth Israel Deaconess Medical Center
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (-0 and)
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (APQ-04219-10)
- Universidade Federal de Juiz de Fora
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI022571, R01AI022571)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lipid droplets, phagosome, macrophages, phagocytosis, host-pathogen interaction, innate immunity, phagosome maturation, inflammation, bacterial infection, parasitic infection, viral infection
- MeSH terms
- Animals, Bacteria, Inclusion Bodies, Humans, Immunity, Innate, Infections, Inflammation, Macrophages, Neutrophils, Phagocytosis, Phagosomes, Inflammation Mediators, Mice
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