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DNA Damage Repair and Bacterial Pathogens
Open accessAbstract
All species require DNA repair pathways to maintain the integrity of their genomes. Bacterial damage repair mechanisms have broader roles encompassing responses to stress, long-term colonization, as well as virulence. The SOS response regulates DNA repair and damage tolerance genes in many bacterial species. This article highlights the bacterial SOS response and its significance in bacterial adaptation and pathogenesis, as well as DNA damage responses provoked by bacterial pathogens in the mammalian host.
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“Three TLS polymerases were shown to be regulated by pivotal SOS regulator/repressor LexA: Pol II (polB), Pol IV (dinB) and Pol V [128].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [128]
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Metadata
- Authors
- Žgur-Bertok, D.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-11-07
- Volume
- 9
- Issue
- 11
- Pages
- e1003711
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC3820712
- OpenAlex
- W2139975770
- Cited by
- 117
- References
- 35
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 8 · 2014: 3
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Javna Agencija za Raziskovalno Dejavnost RS (J3-3624)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- DNA repair, pathogenic bacteria, SOS response, bacterial virulence, bacterial adaptation, host-pathogen interaction, stress response, bacterial colonization
- MeSH terms
- Animals, Bacteria, Bacterial Infections, DNA, Bacterial, Humans, SOS Response, Genetics
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