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Cited by 35IL-33, ST2, and ILC PathwaysT-cell and B-cell ImmunologyImmune responses and vaccinations

Innate lymphoid cells: new players in IL-17-mediated antifungal immunity

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Gladiator, André, LeibundGut-Landmann, Salomé·2013·PLoS Pathogens
DOI 10.1371/journal.ppat.1003763PMC PMC3861514
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Abstract

ISSN:1553-7374

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Crossref · 10.1371/journal.ppat.1003763

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  • ILCs contribute to effective host defense against mucocutaneous fungal challenge.

    “ILCs contribute to effective host defense against mucocutaneous fungal challenge [92,93].”

    From Host–Candida auris interactions in the skin (2026) · cites this paper as [92]

    The section “Which Cellular Sources Provide IL-17 during Fungal Infection?” reports that depleting ILC3s makes mice highly susceptible to oropharyngeal candidiasis, supporting a role in mucosal fungal defense. It does not establish the same protective role for ILCs across cutaneous infections or in humans; the paper says the human role remains a question. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Distinct cytokine requirements exist across mucocutaneous tissues, and IL-17-producing ILCs are key effectors that maintain antifungal barrier immunity in the skin.

    “These findings highlight distinct cytokine requirements across mucocutaneous tissues and underscore IL-17-producing ILCs as key effectors that maintain antifungal barrier immunity in the skin.”

    From Host–Candida auris interactions in the skin (2026) · cites this paper as [92]

    “How Is IL-17 Production by ILCs Regulated?” describes different cytokine requirements in the oral and gut mucosa, supporting tissue-dependent regulation. But “Which Cellular Sources Provide IL-17 during Fungal Infection?” implicates ILC3s in oral candidiasis and says γδ T cells appear more important in the skin; it does not establish IL-17-producing ILCs as key effectors maintaining antifungal immunity there. (LLM, conf=0.89)

    Experimental — accuracy not yet measured

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References 32 · Cited by 35

Research works printed but not linked: 27

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Authors
Gladiator, A., & LeibundGut-Landmann, S.
Affiliations
ETH Zurich (CH)
ORCID
Gladiator, André
Venue
PLoS Pathogens
Publisher
Public Library of Science (PLoS)
Published
2013-12-12
Volume
9
Issue
12
Pages
e1003763
ISSN
  • 1553-7366 (ISSN-L)
  • 1553-7374
DOI
10.1371/journal.ppat.1003763
PMC
PMC3861514
OpenAlex
W1968661266
Cited by
35
References
32
Citations by year
2026: 4 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 4
FWCI
2.21
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Pathogens (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
  • ETH Zürich Research Collection (cc-by)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (123342)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
innate lymphoid cells, IL-17, antifungal immunity, fungal infection, IL-17A, IL-17F, Th17 cells
MeSH terms
Animals, Candida albicans, Fungi, Humans, Immunity, Innate, Lymphocytes, Mice, Transgenic, Mycoses, Interleukin-17, Mice

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