The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Open accessAbstract
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD39, but those specific for EBV and CMV do not. CD39 expressed by CD8+ T cells in chronic infection is enzymatically active, co-expressed with PD-1, marks cells with a transcriptional signature of T cell exhaustion and correlates with viral load in HIV and HCV. In the mouse model of chronic Lymphocytic Choriomeningitis Virus infection, virus-specific CD8+ T cells contain a population of CD39high CD8+ T cells that is absent in functional memory cells elicited by acute infection. This CD39high CD8+ T cell population is enriched for cells with the phenotypic and functional profile of terminal exhaustion. These findings provide a new marker of T cell exhaustion, and implicate the purinergic pathway in the regulation of T cell exhaustion.
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Self-citationBystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
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Metadata
- Authors
- Gupta, P. K., Godec, J., Wolski, D., Adland, E., Yates, K., Pauken, K. E., Cosgrove, C., Ledderose, C., Junger, W. G., Robson, S. C., Wherry, E. J., Alter, G., Goulder, P. J. R., Klenerman, P., Sharpe, A. H., Lauer, G. M., & Haining, W. N.
- Venue
- PLOS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-10-20
- Volume
- 11
- Issue
- 10
- Pages
- e1005177
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2134122465
- Cited by
- 396
- References
- 57
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gupta, P. K., Godec, J., Wolski, D., Adland, E., Yates, K., Pauken, K. E., Cosgrove, C., Ledderose, C., Junger, W. G., Robson, S. C., Wherry, E. J., Alter, G., Goulder, P. J. R., Klenerman, P., Sharpe, A. H., Lauer, G. M., & Haining, W. N. (2015). CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLOS Pathogens. https://doi.org/10.1371/journal.ppat.1005177
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