IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

Cited by (258)

Items 201–258 of 258

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3. Legionella pneumophila infection-mediated regulation of RICTOR via miR-218 in U937 macrophage cells
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4. Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs
   Richard V. Szeligowski, François N. Miros, Andres Saez, Marisa DeCiucis, Günter P. Wagner, Hongying Shen · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
5. Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages
   Clark D Russell, Jennifer Marshall, Brian J. McHugh, Bartosz Michno, Justyna Cholewa-Waclaw, Gonzalo Yebra, Jelimo Chepsat, Gareth‐Rhys Jones, Martin P. McHugh, Nicola N. Lynskey et al. · 2026 · Science Advances
6. Diabetes impairs IFNγ-dependent antibacterial defense in the lungs
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7. Innate immune responses and monocyte-derived phagocyte recruitment in protective immunity to pathogenic bacteria: insights from Legionella pneumophila
   Danielle P. A. Mascarenhas, Dario S. Zamboni · 2024 · Current Opinion in Microbiology
8. Uncovering complex molecular networks in host–pathogen interactions using systems biology
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9. Outer membrane vesicles of Glaesserlla parasuis activate the endosomal cGAS–STING–IRF3 pathway through nucleic acid payload delivery: a biological perspective on host defense protocol optimization
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11. Synergistic antipersister, efflux inhibitory & antibiofilm activities of vaginal Lactobacillus-derived postbiotics against UPEC: toward a novel therapeutic for utis
    Veena G Nair, David Raj Chellappan, Ramya Devi Durai, Rajesh B. R. D. Yamajala, Dhiviya Narbhavi, A Anupriya, Nagarajan Prabhusaran, Saisubramanian Nagarajan · 2026 · Scientific Reports
12. Bovine blood derived macrophages are unable to control Coxiella burnetii replication under hypoxic conditions
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13. Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense
    Charles N. S. Allen, Dallas A. Banks, M.D. Shuster, Stefanie N. Vogel, Tamara J. O’Connor, Volker Briken · 2023 · Infection and Immunity
14. Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions
    Tshegofatso Ngwaga, Deepika Chauhan, Abigail G. Salberg, Stephanie R. Shames · 2023 · PLoS Pathogens
15. Neutrophil-derived itaconate facilitates tiered pulmonary inflammation via Kdm5b-associated epigenetic remodeling in alveolar macrophages
    Gyumin Lim, Ju‐Yeon Kim, Doyoung Park, Jeong Hee Lee, Yeon Jin Roh, Moses Yang, Soowan Lee, Seungbok Yang, Sojeong Baek, Jumi Park et al. · 2026 · Cell Reports
16. Improved cure rate of periprosthetic joint infection through targeted antibiotic therapy based on integrated pathogen diagnosis strategy
    Qijin Wang, Yongfa Chen, Yang Chen, Jianhua Lv, Haiqi Ding, Jiagu Huang, Jiexin Huang, Zida Huang, Bin Yang, Wenming Zhang et al. · 2024 · Frontiers in Cellular and Infection Microbiology
17. Sorting of Phagocytic Cells Infected with Legionella pneumophila
    Monica Rolando, Carmen Buchrieser · 2019 · Methods in molecular biology
18. TNF and type I IFN induction of the IRG1-itaconate pathway restricts Coxiella burnetii replication within mouse macrophages
    Mark A. Boyer, Natasha Lopes Fischer, Sunny Shin · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
19. Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis
    Gareth‐Rhys Jones, Broc Drury, Tobi Alegbe, Monika Krzak, Lizi M. Hegarty, Tim Raine, Adam Bryne, Carl A. Anderson, Gwo‐Tzer Ho, Calum C. Bain · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
20. Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture
    Md Nur A Alam Siddique, Fabian Kellermeier, Martha Ölke, Mingming Zhao, Konrad Büssow, Peter Josef Oefner, Anja Lührmann, Katja Dettmer, Roland Lang · 2024 · Frontiers in Immunology
21. Metabolic responses to Staphylococcus aureus airway infection
    Dorothea Bünsow, Volker Winstel · 2025 · American Journal of Physiology-Cell Physiology
22. Interferon‐Like Signaling Pathway in Crustaceans: Structure, Immune Function, and Prospects for Disease Control in Aquaculture
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23. RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge
    Krishna J. Majithia, Morgan Brittany Johnson · 2025 · Frontiers in Immunology
24. 4-octyl itaconate modulates virulence-associated phenotypes and oxidative stress resistance in avian pathogenic Escherichia coli by targeting menB and wza
    Chuanyan Che, Xiuqi Fan, Haiyang Wang, Zhihao Wang, Yinli Bao, Wei Jie Jiang, Saqib Nawaz, Huifang Yin, Xiangan Han · 2025 · Poultry Science
25. Damage-associated molecular patterns as metabolic regulators of innate immunity
    Tristram A.J. Ryan, Ivan Zanoni, Marco Di Gioia · 2025 · Elsevier eBooks
26. The short chain fatty acid butyrate prevents intracellular replication of Legionella by regulating cysteine levels in macrophages
    Gilu Abraham, Angavai Swaminathan, Christopher K. Barlow, Thanh Ngoc Nguyen, Tejasvini Bhuvan, Tracy S P Heng, Michael Lazarou, Ronan Kapétanovic, Matthew J. Sweet, Ana Traven et al. · 2021 · Research Square
27. Irg1 /itaconate activates Nrf2/HO-1 pathway and mitigates septic liver injury in mice
    Tingting Zhang, Kexin Li, Jinghuan Qiu, Li Zhang, Xiaoliang Wang, Qiuhong Zhang, Yin Qin, Jie Liu, Gang Liu · 2024 · European Journal of Inflammation
28. From inflammation to innovation: Exploring the emerging roles of itaconate in ARDS
    Guixiang Yang, Ling Hu, Min Zhong, Xia Huang, Jianhua Li · 2026 · Life Sciences
29. Metabolic danger signals: TCA cycle metabolites regulate immunity and disease
    Tristram A. J. Ryan, Ivan Zanoni · 2026 · Cell chemical biology
30. Imaging Flow Cytometry of Legionella-Containing Vacuoles in Intact and Homogenized Wild-Type and Mutant Dictyostelium
    Amanda Welin, Dario Hüsler, Hubert Hilbi · 2023 · Methods in molecular biology
31. Whole Genome RNA Sequencing in Holstein Bull Spermatozoa with Different Cryoresistance
    O. Yu. Barkova, D. A. Starikova, I. V. Chistyakova, Н. В. Плешанов · 2025 · Russian Journal of Genetics
32. Influence of chemical compounds and cellautonomous immunity on the replication of sexually transmitted pathogens
    Tímea Raffai · 2020
33. Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs
    Richard V. Szeligowski, François N. Miros, Andres Saez, Marisa DeCiucis, Günter P. Wagner, Hongying Shen · 2025 · eLife
34. Intracellular C. neoformans infection stimulates increased glycolytic activity in fetal liver-derived alveolar-like macrophages
    Derek A. Wiggins, Josh B. Griggs, Andrew England, Emily N. Callison, Cedra H. Kamel, Cathrine A. Hasan, A. Todd Davis, Morgan E. Chappell, Kayla N. Conner, Andrew J. Olive et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
35. Towards re-purposing BH3-mimetics in Legionella and viral infections
    Thomas Naderer · 2017 · Expert Review of Anti-infective Therapy
36. Nutritional virulence of Legionella pneumophila.
    Ashley Best · 2018 · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville)
37. Immune control of Legionella pneumophila lung infection
    Chao Yang · 2018 · Minerva Access (University of Melbourne)
38. Type 1 Interferon Limits Phagocyte Antimicrobial Function by Modulating Lysosomal Cholesterol
    Joel Mei Jou Tan · 2019 · TSpace (University of Toronto)
39. Faculty Opinions recommendation of Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
    Mihai Gheorghe Netea, Jorge Domínguez‐Andrés · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
40. Affinity Enrichment of Salmonella-Modified Membranes from Murine Macrophages for Proteomic Analyses
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41. IL-6–Caspase 3 Axis Plays an Important Role in Enteritis Caused by Legionella pneumophila Pulmonary Infection
    Dahui Zhao, Xuefeng Duan, Li Zhu, Min Fang, Tian Qin, Yuhai Bi · 2025 · Microorganisms
42. Transcripts of COL4A2, IRG1, MMP12 genes as potential biomarkers of bull sperm quality
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43. Dissecting antimicrobial logic: species-specific strategies for intracellular pathogen defense
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44. Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs
    Richard V. Szeligowski, François N. Miros, Andres Saez, Marisa DeCiucis, Günter P. Wagner, Hongying Shen · 2025 · eLife
45. The Legionella phosphocholinase AnkX modulates IMPDH2 regulation and cytoophidia dynamics
    Pia Stauffer, Marietta S. Kaspers, Anna Leoni Swart, Philipp Ochtrop, Bente Siebels, Vivian Pogenberg, Daniel Ferreiro Otero, Andreas Brockmeyer, Camille Schmid, Petra Janning et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
46. Mise en évidence de gènes d'amibes libres impliqués dans l'interaction avec des bactéries intracellulaires
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47. The inflammatory response of primary epithelial cells of the female genital tract to Chlamydia trachomatis infection, and its exacerbation by type-I interferon
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48. The role of O-GlcNAcylation in the pathophysiology of Systemic Lupus Erythematosus
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50. Polyphosphates Attenuate Interleukin‐12 Production in Macrophages Infected With Legionella pneumophila
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53. Itaconate and its derivatives in human health and diseases
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55. Fatty acid-dependent cidality in Mycobacterium avium and Mycobacterium abscessus: intracellular acidification by itaconic acid
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56. Ex vivo functional immune alterations in ICU patients with Legionnaires’ disease, a proof-of-concept study
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57. 4‐Octyl Itaconate Suppresses Virulence of Multidrug‐Resistant Avian Pathogenic Escherichia coli via Cysteine Alkylation of LuxS, Icl, and OmpA
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