CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

Swanson, Phillip A., Hart, Geoffrey T., Russo, Matthew V., Nayak, Debasis, Yazew, Takele, Peña, Mirna, Khan, Shahid M., Janse, Chris J. +2 more·2016·PLOS Pathogens

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    Douglas Esteves Teixeira¹, Sarah A.S. Alves, Alessandro S. Pinheiro, Leandro S. Silva, Rodrigo Pacheco Silva-Aguiar, Diogo B. Peruchetti, Tatiana Almeida Pádua, Mariana Conceicao de Souza, Celso Caruso‐Neves, Ana Acácia S. Pinheiro · 2025 · Frontiers in Cellular and Infection Microbiology
  4. IFNγ-inducible Gbp4 and Irgb6 contribute to experimental cerebral malaria pathology in the olfactory bulb
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  5. Microglia exhibit a dynamic response, modulating inducible nitric oxide synthase expression and the production of pro-inflammatory cytokines during experimental cerebral malaria
    Lucas Freire-Antunes, Uyla Ornellas-Garcia, Marcos Vinícius Rangel-Ferreira, Mônica Lucas Ribeiro-Almeida, Leonardo J. M. Carvalho, Cláudio Tadeu Daniel‐Ribeiro, Flávia Lima Ribeiro-Gomes · 2025 · Frontiers in Immunology
  6. Activation of the HIF1α Pathway in Neurologic Disease: A Targetable Master Regulator to Reduce Neuropathology
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  7. Human Cerebral Malaria and Experimental Cerebral Malaria in Mice: Relevance and Applicability
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  8. Cerebral malaria: Understanding the parasite pathogenesis in the brain
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  9. Cerebral Malaria: Clinicians, Extracellular Vesicles, and Therapeutically-Rational Exchange (T-REX)
    Ryan Philip Jajosky, Audrey Nadine Jajosky, Philip G. Jajosky · 2024 · Preprints.org
  10. Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier
    Alina Batzilla, Pia Dernick, Jon Bezney, Andreas R. Gschwind, Fumio Nakaki, Mireia Altadill, Hannah Fleckenstein, Livia Piatti, Sílvia Sanz, Manuel Fiegl et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Malaria: pathology, immune response, and vaccine design: A mini review
    Henry S. Pan, Haley O. Tucker · 2020 · Neurology and Neuroscience
  12. The Liver-Stage Plasmodium Infection is a Critical Checkpoint for Development of Experimental Cerebral Malaria
    Yuko Sato, Stefanie Ries, Werner Stenzel, Simon Fillatreau, Kai Matuschewski · 2018 · SSRN Electronic Journal
  13. Studies on the immunological mechanisms leading to protection or pathology during malaria infection
    Daniel McGuire · 2019
  14. Cerebral Malaria
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  15. Cerebral malaria is regulated by host mediated changes in Plasmodium gene expression
    Clare Kai Cimperman, Mirna Peña, Sohret Meryem Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, Chen‐Feng Qi, Daniel E. Sturdevant, Louis H. Miller, Patrick L. Collins et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Malaria
    Jayalakshmi Krishnan · 2023 · BENTHAM SCIENCE PUBLISHERS eBooks
  17. Cytolytic CD8+ T cell response to SARS-CoV-2 and non-SARS-CoV-2-related viruses is associated with severe manifestation of COVID-19
    Kristina Allers, Verena Moos, Jörg Hofmann, Mario Witkowski, Hildrun Haibel, Stefan Angermair, Thomas Schneider · 2023 · Clinical Immunology
  18. Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells
    Jacob Hildebrand, Noah R. Daniels, Emma M. Dehm, Benjamin D. Fisher, Joseph K. Guter, Chris J. Janse, Erin D. Lucas, Jules A. Sangala, Trevor N. Tankersley, Geoffrey T. Hart et al. · 2025 · PLoS Pathogens
  19. Additional file 2 of Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria
    Yi Wang, Shen, Yan, Liang, Jiao, Wang, Shubiao, Yuxiao Huang, Zhu, Qinghao, Zhang, Xizhi, Kangjie Yu, Tong, Guodong, Chao Yang et al. · 2024 · Figshare
  20. Additional file 1 of Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria
    Yi Wang, Yan Shen, Liang, Jiao, Wang, Shubiao, Yuxiao Huang, Zhu, Qinghao, Zhang, Xizhi, Kangjie Yu, Tong, Guodong, Chao Yang et al. · 2024 · Figshare
  21. Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model
    Sha-sha Chen, Qingxin Yang, Yu Zhong, Defu Liu, Lifang Zhou, Han-cheng Wei, Changling Li, Junwei Song, Yu-hang Wang, Xiao Hu et al. · 2026 · mBio
  22. Etude de la présentation des antigènes du CMH de classe II aux lymphocytes T CD4 au cours du stade sanguin du paludisme chez la souris
    Marion Draheim · 2017
  23. Rôle de la présentation antigénique par les cellules endothéliales de la barrière hémato-encéphalique dans les pathologies inflammatoires affectant le système nerveux central
    Céline Meyer · 2018
  24. Etude de l'impact des infections parasitaires et virales sur les maladies inflammatoires médiées par les lymphocytes T
    Ali Hassan · 2019 · theses.fr (ABES)
  25. Role of ATP2B4 and human malaria : looking for functional genetic variants associated with malaria
    Samia Nisar · 2020
  26. Is the Association of Granzyme B and the Exported Parasite Hsp70 a Possible Trojan Horse of Severe Malaria?
    Tendamudzimu Harmfree Dongola, Addmore Shonhai · 2026 · Advances in experimental medicine and biology