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Toll-like receptor 4 in acute viral infection: Too much of a good thing
Open accessAbstract
Although a well-regulated inflammatory response is a vital defense mechanism against viral infection, too much inflammation can be detrimental.Excessive inflammatory responses, which are characterized by elevated levels of a broad array of pro-inflammatory cytokines and chemokines, have been observed in a wide variety of viral diseases associated with serious morbidity and mortality.Examples of this include acute lung injury caused by infections with respiratory syncytial virus (RSV), influenza A virus (IAV), or severe acute respiratory syndrome coronavirus (SARS-CoV).Excessive inflammatory responses induced by viral infections are not restricted to the lung but can be systemic, as reported for Ebola virus (EBOV) disease and severe dengue [1][2][3][4][5].The reasons leading to an unbalanced inflammatory response in certain viral infections are not well understood and are most likely multifactorial.Here, we explore the role of toll-like receptor 4 (TLR4) in the induction of damaging inflammatory responses during acute viral infections.
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Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356
Cited by
Aboudounya, M. M., & Heads, R. J. (2021) · Mediators of Inflammation · doi:10.1155/2021/8874339 · Cited by 346
Li, L., Acioglu, C., Heary, R. F., & Elkabes, S. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.10.007 · Cited by 283
Sex differences in inflammation, redox biology, mitochondria and autoimmunity
Di Florio, D. N., Sin, J., Coronado, M. J., Atwal, P. S., & Fairweather, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101482 · Cited by 185
Rosa, B. A., Ahmed, M., Singh, D. K., Choreño-Parra, J. A., Cole, J., Jiménez-Álvarez, L. A., Rodríguez-Reyna, T. S., Singh, B., Gonzalez, O., Carrion, R., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01829-4 · Cited by 106
Metadata
- Authors
- Olejnik, J., Hume, A. J., & Mühlberger, E.
- Venue
- PLOS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-12-20
- Volume
- 14
- Issue
- 12
- Pages
- e1007390
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2905159884
- Cited by
- 200
- References
- 1
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Olejnik, J., Hume, A. J., & Mühlberger, E. (2018). Toll-like receptor 4 in acute viral infection: Too much of a good thing. PLOS Pathogens. https://doi.org/10.1371/journal.ppat.1007390
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
