The DOI matches its Crossref record.
Size Distributions of Maternal and Fetal DNA in Maternal Plasma
Abstract
Background: The discovery of fetal DNA in maternal plasma has opened up an approach for noninvasive prenatal diagnosis. Despite the rapid expansion in clinical applications, the molecular characteristics of plasma DNA in pregnant women remain unclear. Methods: We investigated the size distribution of plasma DNA in 34 nonpregnant women and 31 pregnant women, using a panel of quantitative PCR assays with different amplicon sizes targeting the leptin gene. We also determined the size distribution of fetal DNA in maternal plasma by targeting the SRY gene. Results: The median percentages of plasma DNA with size >201 bp were 57% and 14% for pregnant and nonpregnant women, respectively (P <0.001, Mann–Whitney test). The median percentages of fetal-derived DNA with sizes >193 bp and >313 bp were 20% and 0%, respectively, in maternal plasma. Conclusion: Plasma DNA molecules are mainly short DNA fragments. The DNA fragments in the plasma of pregnant women are significantly longer than those in the plasma of nonpregnant women, and the maternal-derived DNA molecules are longer than the fetal-derived ones.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Liquid Biopsies: Genotyping Circulating Tumor DNA
Diaz, L. A., & Bardelli, A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2011 · Cited by 2,210
High Fragmentation Characterizes Tumour-Derived Circulating DNA
Mouliere, F., Robert, B., Arnau Peyrotte, E., Del Rio, M., Ychou, M., Molina, F., Gongora, C., & Thierry, A. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023418 · Cited by 567
Lun, F. M. F., Tsui, N. B. Y., Chan, K. C. A., Leung, T. Y., Lau, T. K., Charoenkwan, P., Chow, K. C. K., Lo, W. Y. W., Wanapirak, C., Sanguansermsri, T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810373105 · Cited by 355
Self-citationThe use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis
Wright, C. F., & Burton, H. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn047 · Cited by 257
Lo, J. O., Feist, C. D., Norton, M. E., & Caughey, A. B. (2014) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000029 · Cited by 42
Metadata
- Authors
- Chan, K. C. A., Zhang, J., Hui, A. B. Y., Wong, N., Lau, T. K., Leung, T. N., Lo, K.-W., Huang, D. W. S., & Lo, Y. M. D.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-01
- Volume
- 50
- Issue
- 1
- Pages
- 88-92
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2151056739
- Cited by
- 584
- References
- 0
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Size Distributions of Maternal and Fetal DNA in Maternal Plasma. https://app.cochat.ai/papers/10.1373/clinchem.2003.024893
- The paper
- Chan, K. C. A., Zhang, J., Hui, A. B. Y., Wong, N., Lau, T. K., Leung, T. N., Lo, K.-W., Huang, D. W. S., & Lo, Y. M. D. (2004). Size Distributions of Maternal and Fetal DNA in Maternal Plasma. Clinical Chemistry. https://doi.org/10.1373/clinchem.2003.024893
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
