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Cited by 96Mass Spectrometry Techniques and ApplicationsBacterial Identification and Susceptibility TestingAdvanced Proteomics Techniques and Applications

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Applications of MALDI Mass Spectrometry in Clinical Chemistry

Duncan, Mark W, Nedelkov, Dobrin, Walsh, Ryan, Hattan, Stephen J·2016·Clinical Chemistry
DOI 10.1373/clinchem.2015.239491
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Abstract

BACKGROUND: MALDI-TOF mass spectrometry (MS) is set to make inroads into clinical chemistry because it offers advantages over other analytical platforms. These advantages include low acquisition and operating costs, ease of use, ruggedness, and high throughput. When coupled with innovative front-end strategies and applied to important clinical problems, it can deliver rapid, sensitive, and cost-effective assays. CONTENT: This review describes the general principles of MALDI-TOF MS, highlights the unique features of the platform, and discusses some practical methods based upon it. There is substantial potential for MALDI-TOF MS to make further inroads into clinical chemistry because of the selectivity of mass detection and its ability to independently quantify proteoforms. SUMMARY: MALDI-TOF MS has already transformed the practice of clinical microbiology and this review illustrates how and why it is now set to play an increasingly important role in in vitro diagnostics in particular, and clinical chemistry in general.

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Metadata

Authors
Duncan, M. W., Nedelkov, D., Walsh, R., & Hattan, S. J.
Affiliations
  • King Saud University (SA)
  • Arizona State University (US)
  • University of Colorado Anschutz (US)
  • SimulTOF Systems (United States) (US)
Corresponding author
Duncan, Mark W
ORCID
Duncan, Mark W
Venue
Clinical Chemistry
Publisher
Oxford University Press (OUP)
Published
2016-01-01
Volume
62
Issue
1
Pages
134-143
ISSN
  • 0009-9147 (ISSN-L)
  • 1530-8561
DOI
10.1373/clinchem.2015.239491
OpenAlex
W2179704918
Cited by
96
References
69
Citations by year
2026: 7 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 16 · 2019: 14 · 2018: 9 · 2017: 3 · 2016: 5
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Clinical Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
  • Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
  • Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords
MALDI-TOF mass spectrometry, in vitro diagnostics, clinical microbiology, proteoforms, rapid diagnostic tests, high-throughput analysis
MeSH terms
Chemistry, Clinical, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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