Harmonization of Serum Thyroid-Stimulating Hormone Measurements Paves the Way for the Adoption of a More Uniform Reference Interval

Thienpont, Linda M; Van Uytfanghe, Katleen; De Grande, Linde A C; Reynders, Dries; Das, Barnali; Faix, James D; MacKenzie, Finlay; Decallonne, Brigitte; Hishinuma, Akira; Lapauw, Bruno; Taelman, Paul; Van Crombrugge, Paul; Van den Bruel, Annick; Velkeniers, Brigitte; Williams, Paul

doi:10.1373/clinchem.2016.269456

Harmonization of Serum Thyroid-Stimulating Hormone Measurements Paves the Way for the Adoption of a More Uniform Reference Interval

BACKGROUND The IFCC Committee for Standardization of Thyroid Function Tests developed a global harmonization approach for thyroid-stimulating hormone measurements. It is based on a multiassay method comparison study with clinical serum samples and target setting with a robust factor analysis meth…