The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
COPD in Never Smokers
Open accessAbstract
BACKGROUND: Never smokers comprise a substantial proportion of patients with COPD. Their characteristics and possible risk factors in this population are not yet well defined. METHODS: We analyzed data from 14 countries that participated in the international, population-based Burden of Obstructive Lung Disease (BOLD) study. Participants were aged ≥ 40 years and completed postbronchodilator spirometry testing plus questionnaires about respiratory symptoms, health status, and exposure to COPD risk factors. A diagnosis of COPD was based on the postbronchodilator FEV₁/FVC ratio, according to current GOLD (Global Initiative for Obstructive Lung Disease) guidelines. In addition to this, the lower limit of normal (LLN) was evaluated as an alternative threshold for the FEV₁/FVC ratio. RESULTS: Among 4,291 never smokers, 6.6% met criteria for mild (GOLD stage I) COPD, and 5.6% met criteria for moderate to very severe (GOLD stage II+) COPD. Although never smokers were less likely to have COPD and had less severe COPD than ever smokers, never smokers nonetheless comprised 23.3% (240/1,031) of those classified with GOLD stage II+ COPD. This proportion was similar, 20.5% (171/832), even when the LLN was used as a threshold for the FEV₁/FVC ratio. Predictors of COPD in never smokers include age, education, occupational exposure, childhood respiratory diseases, and BMI alterations. CONCLUSION: This multicenter international study confirms previous evidence that never smokers comprise a substantial proportion of individuals with COPD. Our data suggest that, in addition to increased age, a prior diagnosis of asthma and, among women, lower education levels are associated with an increased risk for COPD among never smokers.
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
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Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925
Self-citationSpirometric Reference Values from a Sample of the General U.S. Population
HANKINSON, J. L., ODENCRANTZ, J. R., & FEDAN, K. B. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.1.9712108 · Cited by 4,206
Celli, B. R., Cote, C. G., Marin, J. M., Casanova, C., Montes de Oca, M., Mendez, R. A., Pinto Plata, V., & Cabral, H. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa021322 · Cited by 4,015
Rabe, K. F. (2007) · American Journal of Respiratory and Critical Care Medicine · Cited by 2,567
A Note on Robust Variance Estimation for Cluster‐Correlated Data
Williams, R. L. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00645.x · Cited by 2,501
Buist, A. S., McBurnie, M. A., Vollmer, W. M., Gillespie, S., Burney, P., Mannino, D. M., Menezes, A. M., Sullivan, S. D., Lee, T. A., Weiss, K. B., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61377-4 · Cited by 2,366
Self-citationChronic obstructive pulmonary disease in non-smokers
Salvi, S. S., & Barnes, P. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61303-9 · Cited by 1,368
Cited by
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0218pp · Cited by 3,187
Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision
Celli, B., Fabbri, L., Criner, G., Martinez, F. J., Mannino, D., Vogelmeier, C., Montes de Oca, M., Papi, A., Sin, D. D., Han, M. K., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202204-0671pp · Cited by 518
Self-citationImproving lung health in low-income and middle-income countries: from challenges to solutions
Meghji, J., Mortimer, K., Agusti, A., Allwood, B. W., Asher, I., Bateman, E. D., Bissell, K., Bolton, C. E., Bush, A., Celli, B., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00458-x · Cited by 470
Self-citationWhat is asthma−COPD overlap syndrome? Towards a consensus definition from a round table discussion
Sin, D. D., Miravitlles, M., Mannino, D. M., Soriano, J. B., Price, D., Celli, B. R., Leung, J. M., Nakano, Y., Park, H. Y., Wark, P. A., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.00436-2016 · Cited by 367
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Metadata
- Authors
- Lamprecht, B., McBurnie, M. A., Vollmer, W. M., Gudmundsson, G., Welte, T., Nizankowska-Mogilnicka, E., Studnicka, M., Bateman, E., Anto, J. M., Burney, P., Mannino, D. M., & Buist, S. A.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 139
- Issue
- 4
- Pages
- 752-763
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2155767904
- Cited by
- 526
- References
- 51
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lamprecht, B., McBurnie, M. A., Vollmer, W. M., Gudmundsson, G., Welte, T., Nizankowska-Mogilnicka, E., Studnicka, M., Bateman, E., Anto, J. M., Burney, P., Mannino, D. M., & Buist, S. A. (2011). COPD in Never Smokers. Chest. https://doi.org/10.1378/chest.10-1253
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