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The Role of Candida sp Isolated From Bronchoscopic Samples in Nonneutropenic Patients
Abstract
Study objectives To determine the clinical significance of Candida sp isolated from bronchoscopic samples in patients with suspected pneumonia.Design A retrospective chart review was performed in all nonneutropenic adult patients with Candida sp isolates from respiratory secretions obtained by bronchoscopy over a 5-year period (1991 to 1995). Potential risk factors, therapeutic decisions, and outcome were recorded. Microbiological findings, chest radiograph reports, and pathologic material were reviewed. Isolates were classified as definite, probable, or indeterminate contamination, or as definite pulmonary candidiasis, on the basis of histologic findings, therapeutic decisions, and outcome.Setting A 600-bed teaching hospital with 16 beds in a medical-surgical ICU.Patients Thirty-seven consecutive patients with positive cultures for Candida sp from respiratory samples obtained by bronchoscopy were evaluated. Thirty-two of these 37 patients (86.5%) received antibiotic therapy prior to sampling, and 23 (62.2%) were intubated.Results Contamination was classified as definite in 3 patients (8.1%) and probable in 30 others (81.0%). Contamination was indeterminate in two cases (5.4%). Two additional patients (5.4%) received antifungal agents for systemic candidiasis. No cases of pulmonary candidiasis could be demonstrated, although 24 of 28 patients showed protected specimen brush cultures > or = 10(3) cfu/mL.Conclusions Nonneutropenic patients with isolation of Candida sp from bronchoscopic samples, even in high concentrations, are unlikely to have invasive candidiasis. Indication for initiation of antifungal therapy should be based on histologic evidence or identification from sterile specimens.
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“Thus, diagnoses of Candida pneumonia that are based solely on microbiological data are often incorrect [183, 184] (B-III).”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [183]
Citations
Cites
Secular trends in nosocomial primary bloodstream infections in the United States, 1980–1989.
Banerjee, S. N., Emori, T. G., Culver, D. H., Gaynes, R. P., Jarvis, W. R., Horan, T., Edwards, J. R., Tolson, J., Henderson, T., Martone, W. J., et al. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90349-3 · Cited by 880
Komshian, S. V., Uwaydah, A. K., Sobel, J. D., & Crane, L. R. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.3.379 · Cited by 456
Clinical Role of Bronchoalveolar Lavage in Adults with Pulmonary Disease
Goldstein, R. A., Rohatgi, P. K., Bergofsky, E. H., Block, E. R., Daniele, R. P., Dantzker, D. R., Davis, G. S., Hunninghake, G. W., King, T. E., & Metzger, W. J. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.2.481 · Cited by 309
Mg, C., & Ma, P. (1995) · PubMed · Cited by 156
Epidemiology and Control of Fungal Infections
Pfaller, M. A. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.supplement_1.s8 · Cited by 149
Baselski, V. S., Eltorky, M., Coalson, J. J., & Griffin, J. P. (1992) · CHEST Journal · doi:10.1378/chest.102.5_supplement_1.571s · Cited by 146
Primary Candida pneumonia. Experience at a large cancer center and review of the literature.
Haron, E., Vartivarian, S. E., Anaissie, E. A., Dekmezian, R. H., & Bodey, G. P. (1993) · PubMed · Cited by 145
Primary Candida Pneumonia: Experience at a Large Cancer Center and Review of the Literature
Haron, E., Vartivarian, S., Anaissie, E., Dekmezian, R., & Bodey, G. P. (1993) · Medicine · doi:10.1097/00005792-199305000-00001 · Cited by 144
Pfaller, M. A. (1995) · Journal of Hospital Infection · doi:10.1016/0195-6701(95)90036-5 · Cited by 134
Bronchoalveolar Lavage in the Diagnosis of Pulmonary Infiltrates in Patients with Acute Leukemia
Saito, H., Anaissie, E. J., Morice, R. C., Dekmezian, R. H., & Bodey, G. P. (1988) · CHEST Journal · doi:10.1378/chest.94.4.745 · Cited by 120
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Items 101–155 of 155
Heizmann, P., Klefisch, F.-R., & Heizmann, W. R. (2011) · Pharmacology & Pharmacy · doi:10.4236/pp.2011.24046 · Cited by 2
Trifilio, S. M., Heraty, R., Zomas, A., Zhou, Z., Fong, J. L., Liu, D., Zhao, C., Zhang, J., & Mehta, J. (2015) · Transplant Infectious Disease · doi:10.1111/tid.12324 · Cited by 2
Candidemia y candidiasis generalizada
Eggimann, P., & Pittet, D. (2010) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(10)70439-4 · Cited by 2
Xu, W.-M., Shui, W., Lin, J., Lin, Z.-Q., Li, M., Xing, Y.-L., & Zhang, C.-R. (2014) · Medical Mycology · doi:10.1093/mmy/myu068 · Cited by 2
Braun‐Falco, O., Plewig, G., Wolff, H. H., & Burgdorf, W. H. C. (2000) · Springer eBooks · doi:10.1007/978-3-642-97931-6_7 · Cited by 2
Nosocomial Infections in the Pediatric Intensive Care Unit
Sáez‐Llorens, X., & Ramilo, O. (2008) · Springer eBooks · doi:10.1007/978-1-84628-917-0_10 · Cited by 2
Risk factors for lung colonization by Candida albicans in a general ICU
Toma, L., Silvestri, S., Forfori, F., Licitra, G., & Giunta, F. (2008) · Critical Care · doi:10.1186/cc6240 · Cited by 2
Candida Pneumonia in Patients with Hematological Neoplasia
Carvajal, C., Rello, J., & Lipman, J. (2010) · Springer eBooks · doi:10.1007/978-3-642-15742-4_28 · Cited by 1
Self-citationViral colonization in intubated patients: initial pathogen pattern and follow‐up
Hauptmeier, B., Borg, I., Rohde, G. G. U., Anders, A., Kronsbein, J., Gatermann, S. G., Bufe, A., Blum, T. G., Schultze‐Werninghaus, G., & Bauer, T. T. (2009) · The Clinical Respiratory Journal · doi:10.1111/j.1752-699x.2009.00160.x · Cited by 1
Barenfanger, J. E. (2006) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2006.01.002 · Cited by 1
Le Polmoniti: proposta di un percorso condiviso per la diagnosi microbiologica
Farina, C. (2009) · Microbiologia medica · doi:10.4081/mm.2009.2498 · Cited by 1
[Respiratory tract fluid microbiology in an intensive care unit].
Casanova-Cardiel, L. J., Castañón-González, J. A., León-Gutiérrez, M. A., Becerra-Lara, J. J., Calyeca-Sánchez, M. V., Franco-Contreras, A. E., Polanco-Flores, E., González-Green, I., & Martínez-Gutiérrez, M. (2008) · PubMed · Cited by 1
Heizmann, P., & Heizmann, W. R. (2009) · Intensivmedizin und Notfallmedizin · doi:10.1007/s00390-008-0011-2 · Cited by 1
Epidemiology and Management of Candidiasis in Solid Organ Transplant Recipients
Hammadi, A. A., & Ostrosky-Zeichner, L. L. (2016) · Current Fungal Infection Reports · doi:10.1007/s12281-016-0269-y · Cited by 1
Gillissen, A., & Paparoupa, M. (2017) · Pneumo News · doi:10.1007/s15033-017-0668-y · Cited by 1
RESISTANT CANDIDA PNEUMONIA IN TWO PATIENTS WITH CHRONIC KIDNEY DISEASE
Baikunje, S., Upadhyaya, V., Hosmane, G. B., & Saya, R. P. (2014) · Journal of Health and Allied Sciences NU · doi:10.1055/s-0040-1703849 · Cited by 1
Barenfanger, J. E. (2006) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2006.01.001 · Cited by 1
Ventilator-Associated Pneumonia
Chastre, J. E., & Luyt, C. E. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00034-8 · Cited by 1
Fungal Infections: The Role of Prophylaxis and Empiric Therapy in ICU Patients
Meis, J. F. G. M., & Verweij, P. E. (2001) · Perspectives on critical care infectious diseases · doi:10.1007/978-1-4615-0781-9_9 · Cited by 1
Wallace, J. M. (2001) · Journal of Bronchology · doi:10.1097/01.lbr.0000011100.73611.39 · Cited by 1
Microbiology and the diagnosis and treatment of ventilator-associated pneumonia
Eldere, J. V. (2004) · Reviews in Medical Microbiology · doi:10.1097/00013542-200410000-00001 · Cited by 1
MYCOTIC INFECTIONS OF THE LUNG
Cassivi, S. D. (2008) · Elsevier eBooks · doi:10.1016/b978-0-443-06861-4.50047-2 · Cited by 1
Marinò, P. (2017) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 1
Barnes, R. A. (1999) · Current Anaesthesia and Critical Care · doi:10.1016/s0953-7112(99)90026-1 · Cited by 1
Invasive Candidiasis beim nicht-neutropenischen kritisch kranken Patienten
Schwetz, I., Domej, W., & Krause, R. (2007) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-007-0464-0
Candida Infection in Critically Ill Patients
van der Voort, P. H. J. (2008) · Springer eBooks · doi:10.1007/978-88-470-0773-4_21
Candidiasis pulmonar en un paciente no inmunodeprimido
Muñoz, R. D., Valero, F. C., Martínez, V. P., & Mollá, M. A. (2007) · Radiología · doi:10.1016/s0033-8338(07)73828-6
Candidemia e candidosi generalizzata
Eggimann, P., & Pittet, D. (2010) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(10)70266-8
Carvajal, C., & Pacheco, C. (2010) · Clinical Pulmonary Medicine · doi:10.1097/cpm.0b013e3181dabfc7
Dupont, H. (2007) · Réanimation · doi:10.1016/j.reaurg.2007.02.015
Nourdine, K., Beuret, P., Kaaki, M., Carton, M. J., & Ducreux, J. (2000) · Réanimation Urgences · doi:10.1016/s1164-6756(00)90078-1
Esandi, M. E., Dı́az, E., & Rello, J. (1999) · PubMed
Self-citationCandida spp. Em superfície de equipamentos hospitalares de suporte ventilatório ao paciente crítico
da Silva, L. B., Nascente, P. D. S., & Xavier, M. O. (2012) · VITTALLE - Revista de Ciências da Saúde
Clinical Diagnosis of Fungal Infection in the Intensive Care Unit
Flanagan, P. (2002) · Perspectives on critical care infectious diseases · doi:10.1007/978-1-4615-0977-6_6
Diagnosis of ventilator-associated pneumonia
Mariscal, D., Gallego, M., Vallés, J., & Rello, J. (2001) · Reviews in Medical Microbiology · doi:10.1097/00013542-200107000-00003
Self-citationMicrobial etiology and resistance
Rello, J., & Roig, J. (2006) · CRC Press eBooks · doi:10.1201/b13421-55
Self-citationA Case of Candida albicans Pneumonia Diagnosed by Endobronchial Biopsy
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Pneumonies acquises sous ventilation mécanique
Trouillet, J. L., Luyt, C. E., Combes, A., & Chastre, J. E. (2013) · Références en réanimation · doi:10.1007/978-2-8178-0389-0_23
Multani, A., Allard, L. S., & Nelson, J. K. (2019) · OBM Transplantation · doi:10.21926/obm.transplant.1903076
Nania, J. J., & Wright, P. F. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-3695-5.50039-0
Nania, J. J., & Wright, P. F. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1984-0.00034-6
The hermit and the street character: unusual diagnoses in forensic pathology
Guareschi, E. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-824294-0.00001-7
Barnes, R. A., & Sinha, J. (2007) · Springer eBooks · doi:10.1007/978-3-540-34406-3_7
Beatmungsassoziierte Pneumonien
Krueger, W. A., & Daschner, F. D. (2003) · Springer eBooks · doi:10.1007/978-3-642-18958-6_3
The Role of Bronchoscopy in Pulmonary Mycoses
Wallace, J. M. (2001) · Journal of Bronchology · doi:10.1097/00128594-200107000-00017
Barnes, R. A. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1679-8_4
Siddarth, Tripathi, P. K., & Lata, P. (2023) · GLOBAL JOURNAL FOR RESEARCH ANALYSIS · doi:10.36106/gjra/4501871
Candidemie e candidosi invasive
Benitha, Y., & Bleibtreu, A. (2025) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(24)49999-4
Candidemia y candidiasis invasiva
Benitha, Y., & Bleibtreu, A. (2025) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(25)50394-8
Candida in Lung Specimens from Non-Neutropenic ICU Patients: Infection or Colonization ?
Azoulay, É., & Schlemmer, B. (2003) · Springer eBooks · doi:10.1007/978-1-4757-5548-0_18
Evaluation de stratégies thérapeutiques dans des modèles murins de pneumonie
Hraiech, S. (2014) · theses.fr (ABES) · doi:10.70675/872ddfa5zde9bz46a3z9771zb20c29f9a732
Fouere, L., Youinou, M., Schimpf, C., Mongardon, N., Quesnel, C., & Philippart, F. (2026) · medRxiv · doi:10.64898/2026.10.15.26365620
Invasive fungal infections in critically ill patients
Meersseman, W. (2008)
Management of Candida Infections in the Intensive Care Unit
Edwards, J. E. (2002) · Perspectives on critical care infectious diseases · doi:10.1007/978-1-4615-0977-6_7
Metadata
- Authors
- Rello, J., Esandi, M.-E., Diaz, E., Mariscal, D., Gallego, M., & Vallès, J.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 114
- Issue
- 1
- Pages
- 146-149
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2068020847
- Cited by
- 155
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2017: 3 · 2016: 7 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 7
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida, pulmonary candidiasis, non-neutropenic patients, suspected pneumonia, antifungal therapy, protected specimen brush, invasive candidiasis, intubation, antibiotic therapy
- MeSH terms
- Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Antifungal Agents, Bronchi, Bronchoscopy, Candida, Candidiasis, Decision Making, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Neutropenia, Pneumonia, Radiography, Retrospective Studies, Risk Factors, Sputum, Treatment Outcome
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