The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Systemic Effects in COPD
Abstract
The pathogenesis and clinical manifestations of COPD are not restricted to pulmonary inflammation and structural remodeling. Rather, this disorder is associated with clinically significant systemic alterations in biochemistry and organ function. The systemic aspects of COPD include oxidative stress and altered circulating levels of inflammatory mediators and acute-phase proteins. Indeed, an impaired endogenous oxidant-antioxidant balance has been reported in patients experiencing exacerbations of COPD, and others have observed altered circulating levels of several cytokines and adhesion molecules in patients with stable disease. As in other chronic inflammatory conditions, weight loss, muscle wasting, and tissue depletion are commonly seen in COPD patients. Selective wasting of fat-free mass coupled with impaired respiratory and peripheral muscle function and a reduced capacity for exercise occur in COPD patients. Indeed, weight loss may directly impact poor prognosis in COPD patients. The mechanisms underlying weight loss and muscle wasting are incompletely understood but likely involve an imbalance in ongoing processes of protein degradation and replacement. This may include alterations in the relative levels or activities of endocrine hormones such as insulin, growth hormone, testosterone, and glucocorticoids. Furthermore, chronic systemic inflammation involving cytokines such as interleukin-1 and tumor necrosis factor-alpha may be associated with these hormonal changes an…
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“Classically, circulating TNF-α is reported to be higher in COPD patients than controls and negatively correlated to lean mass [23,24]”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [24]
Citations
Cites
PAUWELS, R. A., Buist, A. S., CALVERLEY, P. M. A., Jenkins, C. R., & Hurd, S. S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.5.2101039 · Cited by 6,578
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
Mitch, W. E., & Goldberg, A. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612193352507 · Cited by 1,163
Weight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease
Schols, A. M. W. J., Slangen, J. J. M., Volovics, L., & Wouters, E. F. �. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.9705017 · Cited by 1,080
Self-citationPrognostic Value of Nutritional Status in Chronic Obstructive Pulmonary Disease
LANDBO, C., Prescott, E., Lange, P., Vestbo, J., & Almdal, T. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9902115 · Cited by 1,035
NF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia
D, D. C. G., Mayo, M. W., Madrid, L. V., Wang, C., & Baldwin, A. S. (2000) · Science · doi:10.1126/science.289.5488.2363 · Cited by 922
Systemic oxidative stress in asthma, COPD, and smokers
Rahman, I., Morrison, D., Donaldson, K., & MacNee, W. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.4.8887607 · Cited by 774
Schols, A. M. W. J., Soeters, P. B., Dingemans, A. C., Mostert, R., Frantzen, P. J., & Wouters, E. F. �. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.5.1151 · Cited by 723
Self-citationSchols, A. M. W. J., Buurman, W. A., den Brekel, A. J. S.-V., Dentener, M. A., & Wouters, E. F. �. (1996) · Thorax · doi:10.1136/thx.51.8.819 · Cited by 520
Self-citationLi, Y., Schwartz, R. J., Waddell, I. D., Holloway, B. R., & Reid, M. B. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.871 · Cited by 502
Tumor Necrosis Factor-Alpha Levels and Weight Loss in Chronic Obstructive Pulmonary Disease
Di Francia, M., Barbier, D., Mège, J. L., & OREHEK, J. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.5.7952575 · Cited by 480
Cited by
Metadata
- Authors
- Wouters, E. F. M., Creutzberg, E. C., & Schols, A. M. W. J.
- Affiliations
- Maastricht University Medical Centre (NL)
- Corresponding author
- Wouters, Emil F.M.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 121
- Issue
- 5
- Pages
- 127S-130S
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W1981878902
- Cited by
- 301
- References
- 33
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 11 · 2018: 4 · 2017: 13 · 2016: 8 · 2015: 9 · 2014: 11 · 2013: 14 · 2012: 15
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- chronic obstructive pulmonary disease, systemic effects, oxidative stress, prooxidant-antioxidant balance, inflammatory mediators, acute phase proteins, COPD exacerbations, weight loss, muscle atrophy, cachexia, skeletal muscle protein metabolism, cytokines, interleukin-1, TNF-α, glucocorticoids, insulin, growth hormone, testosterone, exercise capacity, prognosis
- MeSH terms
- Cachexia, Humans, Muscle Proteins, Prognosis, Tumor Necrosis Factor-alpha, Body Mass Index, Pulmonary Disease, Chronic Obstructive
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