Late Recurrent Candida Endocarditis
Abstract
Late recurrent Candida endocarditis (LRCE) developed on a prosthetic mitral valve 22 months after treatment for primary native mitral valve endocarditis. The LRCE was difficult to diagnose; results of two dimensional echocardiography and repeated blood cultures were negative. Only transesophageal echocardiography revealed a vegetation and only lysis centrifugation blood cultures demonstrated candidemia. Postmortem examination revealed a large Candida vegetation on the prosthetic valve and Candida in the mitral valve ring. This case and a review of the literature indicate that Candida endocarditis treated with amphotericin B and prosthetic valve replacement may recur months after treatment, and that LRCE, which is difficult to diagnose and treat, may be best prevented by lifelong antifungal suppressive therapy.
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Candida endocarditis has a propensity for relapse and requires careful follow-up for at least 1 year.
“Candida endocarditis has a propensity for relapse and requires careful follow-up for at least 1 year [227].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [227]
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References 18 · Cited by 51
- Authors
- Johnston, P. G., Lee, J., Domunski, M., Dressler, F., Tucker, E., Rothenberg, M., Cunnion, R. E., Pizzo, P. A., & Walsh, T. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Walsh, Thomas J.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 1991-06
- Volume
- 99
- Issue
- 6
- Pages
- 1531-1533
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2049853321
- Cited by
- 51
- References
- 18
- Citations by year
- 2025: 1 · 2020: 1 · 2018: 1 · 2016: 1
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Keywords
- Candida endocarditis, mitral valve prosthesis, prosthetic valve endocarditis, mitral valve endocarditis, transesophageal echocardiography, candidemia, amphotericin B, prosthetic valve replacement, autopsy
- MeSH terms
- Adult, Candidiasis, Endocarditis, Heart Valve Prosthesis, Humans, Male, Mitral Valve, Recurrence, Time Factors, Ultrasonography
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