The DOI matches its Crossref record, with a small difference in title or year.
Macrophage Virulence Assays
Abstract
Mycobacterium tuberculosis is a facultative intracellular pathogen, which can survive and replicate within the host macrophage. It is transmitted via the aerosol route, which delivers the bacillus to the alveolus of the lungs. The initial phase of granuloma formation within the lung requires that the bacterium is ingested by alveolar macrophages. Intracellular replication begins and an inflammatory reaction, involving recruitment of mononuclear leukocytes to the site, is initiated. The resultant accumulation of mononuclear leukocytes (mono-cytes, macrophages, and lymphocytes) is known as a granuloma. The growth of the mycobacteria at this stage in the infection is largely intracellular and acid fast bacilli can be visualized within the macrophages of the granuloma (1).
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AFB in macrophages can be a useful indicator of TB, but its reliability varies depending on context and method of detection.
“The AFB in macrophages can be a useful indicator of TB, but its reliability varies depending on the context and method of detection. AFBs are a hallmark of M. tuberculosis infection, and their detection in macrophages is a critical component of TB diagnosis. However, the sensitivity and specificity of AFB detection can be influenced by the site of infection, the method of sample collection, and”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [60]
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Mogoantă, C. A., Osman, A., Georgescu, A.-M., Mitroi, A. M., Busuioc, C. I., Tănase, I., Cioboată, R., Liliac, I. M., Cimpeanu, O. L., & Ciolofan, M. S. (2025) · Pathogens · doi:10.3390/pathogens14050479 · Cited by 2
“AFBs can be visualized within these macrophages, making their presence a potential indicator of TB infection [60].”
Metadata
- Authors
- Lukey, P. T., & Hooker, E. U.
- ORCID
- Lukey, Pauline T
- Venue
- Mycobacterium Tuberculosis Protocols
- Publisher
- Humana Press
- Published
- 2003-11-15
- Volume
- 54
- Pages
- 271-280
- OpenAlex
- W2404639345
- Cited by
- 22
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 2
- FWCI
- 4.02
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Humana Press eBooks (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- Mycobacterium tuberculosis, intracellular bacterial replication, granuloma formation, alveolar macrophages, airborne transmission, host-pathogen interaction
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