The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Paraquat and Iron-Dependent Lipid Peroxidation : NADPH Versus NADPH-Generating Systems
Abstract
The aim of this work was to study the effect of paraquat (P2+) on NADPH iron-dependent lipid peroxidation (basal peroxidation) either in the presence of NADPH or in the presence of NADPH-generating systems. When NADPH is present, P2+ potentiates NADPH iron-dependent lipid peroxidation, but use of NADPH-generating systems cancels this effect. This may be attributed to certain components in NADPH-generating systems such as glucose-6-phosphate and sodium isocitrate, which act as iron chelators. The binding of iron by these molecules facilitates its reduction and enhances its reactivity toward dioxygen molecules, leading to the formation of reactive species capable of initiating lipid peroxidation, such as Fe3+-O2-*. Under these conditions of rapid basal peroxidation, any additional reduction of iron(III) by a reduced form of P2+ (P+*) has no apparent effect on the peroxidation itself, probably because the initial reaction between iron(II) and O2 followed by initiation of the peroxidation are both rate-limiting steps in the process. Consequently, any alteration of the composition of the reacting mixture (e.g., buffers or the generating system) must be taken into consideration because the formation of new iron chelates can change the rate of basal peroxidation and will modify the effect of redoxcycling molecules.
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“its toxicity may be expected to be exacerbated by iron, and this is the case”
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Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
Olczak, A. A., Wang, G., & Maier, R. J. (2005) · Free Radical Research · doi:10.1080/10715760500306729 · Cited by 36
Huang, C., & Zhang, X. (2011) · Clinical Toxicology · doi:10.3109/15563650.2011.607459 · Cited by 20
Metadata
- Authors
- Fernandez, Y., Anglade, F., & Mitjavila, S.
- Affiliations
- Institut National de la Recherche Agronomique (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Venue
- Biological Trace Element Research
- Published
- 2000
- Volume
- 74
- Issue
- 3
- Pages
- 191-202
- ISSN
- 0163-4984 (ISSN-L)
- OpenAlex
- W2048973558
- Cited by
- 3
- References
- 23
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Trace Element Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Paraquat toxicity studies and treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- paraquat, iron-dependent lipid peroxidation, NADPH, NADPH-generating system, iron chelation, glucose-6-phosphate, iron reduction, reactive oxygen species, redox cycling, oxidative stress
- MeSH terms
- Animals, Herbicides, Iron, Kinetics, Male, Microsomes, Liver, NADP, Oxidation-Reduction, Oxygen, Oxygen Consumption, Paraquat, Time Factors, Lipid Peroxidation, Rats, Wistar, Rats
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