The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The Role of Genes and Environment in the Etiology of PCOS
Abstract
Both genes and the environment contribute to PCOS. Obesity, exacerbated by poor dietary choices and physical inactivity, worsens PCOS in susceptible individuals. The role of other environmental modifiers such as infectious agents or toxins are speculative. Phenotype confusion has characterized genetic studies of PCOS. Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, the follistatin gene, and a region near the insulin receptor, the evidence supporting linkage is not overwhelming. The strongest case can be made for the region near the insulin receptor gene (but not involving this gene), as it has been identified in two separate studies, and perhaps most importantly has not yet been refuted by larger studies. However, the responsible gene at chromosome 19p13.3 remains to be identified. To date, no gene has been identified that causes or contributes substantially to the development of a PCOS phenotype.
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Legro, R. S., Driscoll, D., Strauss, J. F., Fox, J., & Dunaif, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14956 · Cited by 699
Self-citationPolycystic Ovaries and Hyperandrogenism in Women Taking Valproate for Epilepsy
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Dietary Patterns and Metabolic and Hormonal Parameters in Women with Suspected PCOS
Kowalczyk, K., Kadłubek, S., Krużel, A., Sikora, D., Daniluk, J., & Madej, P. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14082708 · Cited by 4
Metadata
- Authors
- Diamanti-Kandarakis, E., Kandarakis, H., & Legro, R. S.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Legro, Richard S.
- ORCID
- Legro, Richard S.
- Venue
- Endocrine
- Published
- 2006
- Volume
- 30
- Issue
- 1
- Pages
- 19-26
- ISSN
- 0969-711X (ISSN-L)
- OpenAlex
- W1975207893
- Cited by
- 233
- References
- 52
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 26 · 2023: 25 · 2022: 23 · 2021: 23 · 2020: 15 · 2019: 24 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 6
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pennsylvania State University
- Deutsches Krebsforschungszentrum
- National Center for Research Resources (M01 RR10732, M01RR010732)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54-HD34449, K24 HD01476, U54HD034449, K24HD001476)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- polycystic ovary syndrome, etiology, genetic susceptibility, environmental factors, obesity, insulin resistance, insulin receptor gene, CYP11A, follistatin, chromosome 19p13.3, genetic linkage, infectious agents, toxins
- MeSH terms
- Cholesterol Side-Chain Cleavage Enzyme, Chromosomes, Human, 19-20, Environment, Family, Female, Humans, Insulin, Obesity, Polycystic Ovary Syndrome, Receptor, Insulin, Genetic Predisposition to Disease, Follistatin
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