The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Progesterone Treatment of Spinal Cord Injury: Effects on Receptors, Neurotrophins, and Myelination
Open accessAbstract
In addition to its traditional role in reproduction, progesterone (PROG) has demonstrated neuroprotective and promyelinating effects in lesions of the peripheral and central nervous systems, including the spinal cord. The latter is a target of PROG, as nuclear receptors, as well as membrane receptors, are expressed by neurons and/or glial cells. When spinal cord injury (SCI) is produced at the thoracic level, several genes become sensitive to PROG in the region caudal to the lesion site. Although the cellular machinery implicated in PROG neuroprotection is only emerging, neurotrophins, their receptors, and signaling cascades might be part of the molecules involved in this process. In rats with SCI, a 3-d course of PROG treatment increased the mRNA of brain-derived neurotrophic factor (BDNF) and BDNF immunoreactivity in perikaryon and processes of motoneurons, whereas chromatolysis was strongly prevented. The increased expression of BDNF correlated with increased immunoreactivity for the BDNF receptor TrkB and for phosphorylated cAMP-responsive element binding in motoneurons. In the same SCI model, PROG restored myelination, according to measurements of myelin basic protein (MBP) and mRNA levels, and further increased the density of NG2+-positive oligodendrocyte progenitors. These cells might be involved in remyelination of the lesioned spinal cord. Interestingly, similarities in the regulation of molecular parameters and some cellular events attributed to PROG and BDNF (i.e., choline acetyltransferase, Na,K-ATPase, MBP, chromatolysis) suggest that BDNF and PROG might share intracellular pathways. Furthermore, PROG-induced BDNF might regulate, in a paracrine or autocrine fashion, the function of neurons and glial cells and prevent the generation of damage.
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Cites
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
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“…are present not only in developing but also in adult spinal cord neurons (Dreyfus et al., 1999; Schober et al., 1999, Buck et al., 2000), indicating that they might play an important role in neuronal survival (Thoenen et al., 1995) and axonal regeneration (Thoenen, 1995; Sayer et al., 2002).”
CREB: A Major Mediator of Neuronal Neurotrophin Responses
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BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
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“In turn, TrkB activation activates phosphorylation cascades, the best characterized systems being the mitogen-activated protein kinase (MAPK) cascade and the PI-3K/Akt pathway (Mattson et al., 2004).”
Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
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“However, PROG might also bind to the membrane-binding protein 25-Dx and other recently cloned membrane receptors (Labombarda et al., 2003, Zhu et al., 2003 ), suggesting that alternative mechanisms might operate under normal and/or pathological conditions.”
The oligodendrocyte precursor cell in health and disease
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“Gender differences in the outcome of brain injury and cerebral edema also pointed to a protective role of PROG (Stein and Fulop, 1998; Roof and Hall, 2000).”
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Cited by
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The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458
Progesterone and Estrogen Regulate Alzheimer-Like Neuropathology in Female 3xTg-AD Mice
Carroll, J. C., Rosario, E. R., Chang, L., Stanczyk, F. Z., Oddo, S., LaFerla, F. M., & Pike, C. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2718-07.2007 · Cited by 369
“…suggests that progesterone improves hippocampal-dependent spatial memory (Roof et al., 1994) and protects neurons in some (Roof et al., 1994; Alkayed et al., 2000; Hoffman et al., 2003; De Nicola et al., 2006) but not all (Azcoitia et al., 1999; Toung et al., 2004) rodent models of neuronal injury.”
BackgroundProgesterone exerts neuroprotective effects after brain injury
Stein, D. G. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.012 · Cited by 294
“Examination of the spinal cords of these animals revealed that progesterone-treated rats had less white matter damage in the area surrounding the injury site than vehicle-treated controls (De Nicola et al., 2006; Gonzalez et al., 2005; Labombarda et al., 2002; Labombarda et al., 2006).”
BackgroundProgesterone: Therapeutic opportunities for neuroprotection and myelin repair
Schumacher, M., Guennoun, R., Stein, D. G., & Nicola, A. F. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.001 · Cited by 247
“This has been demonstrated after spinal cord transection and in the Wobbler mouse (De Nicola et al., 2003; Gonzalez Deniselle et al., 2005; De Nicola et al., 2006).”
Self-citationThe Role of Sex and Sex Hormones in Neurodegenerative Diseases
Vegeto, E., Villa, A. M., Torre, S. D., Crippa, V., Rusmini, P., Cristofani, R., Galbiati, M., Maggi, A. C., & Poletti, A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz005 · Cited by 240
Metadata
- Authors
- De Nicola, A. F., Gonzalez, S. L., Labombarda, F., Deniselle, M. C. G., Garay, L., Guennoun, R., & Schumacher, M.
- Affiliations
- Universidad de Buenos Aires (AR)
- Inserm (FR)
- Venue
- Journal of Molecular Neuroscience
- Published
- 2006
- Volume
- 28
- Issue
- 1
- Pages
- 3-16
- ISSN
- 0895-8696 (ISSN-L)
- OpenAlex
- W153328306
- Semantic Scholar
- 8ca69c844ba5b9c038c308d3f8e1aa7ece651fa0
- Cited by
- 92
- References
- 93
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad de Buenos Aires (CONICET)
- Fondo para la Investigación Científica y Tecnológica
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- progesterone, spinal cord injury, neuroprotection, brain-derived neurotrophic factor, TrkB receptor, myelination, remyelination, oligodendrocyte progenitors, motor neurons, chromatolysis, myelin basic protein, nuclear receptors, paracrine signaling
- MeSH terms
- Animals, Myelin Basic Protein, Myelin Sheath, Neurons, Oligodendroglia, Progesterone, Receptors, Progesterone, Spinal Cord, Spinal Cord Injuries, Stem Cells, Cyclic AMP Response Element-Binding Protein, Neuroprotective Agents, Brain-Derived Neurotrophic Factor
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- The paper
- De Nicola, A. F., Gonzalez, S. L., Labombarda, F., Deniselle, M. C. G., Garay, L., Guennoun, R., & Schumacher, M. (2006). Progesterone Treatment of Spinal Cord Injury: Effects on Receptors, Neurotrophins, and Myelination. Journal of Molecular Neuroscience. https://doi.org/10.1385/jmn%3A28%3A1%3A3
