The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Endocrine Alterations in Critically Ill Patients With Stroke During the Early Recovery Period
Abstract
Introduction Endocrine abnormalities in critically ill patients with stroke during the early recovery period have not been well characterized.Methods To investigate this issue, 33 consecutive mechanically ventilated patients (27 men) with hemorrhagic (n = 21) or ischemic (n = 12) stroke having a mean age of 57 +/- 12 years were studied. Glasgow Coma Scale score on admission in the hospital was 8 +/- 3. The following basal hormones were measured within 72 hours postextubation: cortisol, corticotropin (ACTH), free thyroxine, tri-iodothyronine, thyroid-stimulating hormone, testosterone, estradiol, follicle-stimulating hormone, luteinizing hormone, growth hormone, and insulin-like growth factor (IGF)-1. Subsequently, a low-dose (1 microg) ACTH stimulation test was performed.Results Twenty-six (79%) patients showed endocrine alterations. The most common change was low IGF-1 levels compatible with growth hormone deficiency (45%), followed by hypogonadism (39%), thyroid dysfunction (36%), and cortisol hyporesponsiveness (33%).Conclusion Neuroendocrine changes occur with high frequency in critically ill patients with stroke during the early recovery period. It remains to be determined whether these changes have implications for functional and/or clinical outcome.
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“Similarly, abrupt and profound decreases in serum testosterone are uniformly seen in critically ill men [74, 84–91].”
From Chapter 1: pathophysiology of hypopituitarism in the setting of brain injury (2012) · cites this paper as [84]
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Chapter 1: pathophysiology of hypopituitarism in the setting of brain injury
Dusick, J. R., Wang, C., Cohan, P., Swerdloff, R., & Kelly, D. F. (2012) · Pituitary · doi:10.1007/s11102-008-0130-6 · Cited by 121
Metadata
- Authors
- Dimopoulou, I., Kouyialis, A. T., Orfanos, S., Armaganidis, A., Tzanela, M., Thalassinos, N., & Tsagarakis, S.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Dimopoulou, Ioanna
- ORCID
- Venue
- Neurocritical Care
- Published
- 2005
- Volume
- 3
- Issue
- 3
- Pages
- 224-229
- ISSN
- 1541-6933 (ISSN-L)
- OpenAlex
- W2006882468
- Cited by
- 40
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2019: 1 · 2018: 1 · 2017: 4 · 2015: 1 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurocritical Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- stroke, endocrine alterations, neuroendocrine dysfunction, critically ill patients, hemorrhagic stroke, ischemic stroke, growth hormone deficiency, insulin-like growth factor I, hypogonadism, thyroid dysfunction, ACTH stimulation test, mechanical ventilation
- MeSH terms
- Aged, Cerebral Hemorrhage, Brain Ischemia, Endocrine System Diseases, Female, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Respiration, Artificial, Critical Illness, Stroke
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