The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Embryonic diapause: development on hold
Abstract
Embryonic diapause, the temporary suspension of development of the embryo, is a fascinating reproductive strategy that has been frequently exploited across the animal kingdom. It is characterized by an arrest in development that occurs at the blastocyst stage in over 130 species of mammals. Its presumed function is to uncouple mating from parturition, to ensure that both occur at the most propitious moment for survival of the species. Diapause can be facultative, i.e. induced by physiological conditions, or obligate, i.e. present in every gestation of a species. In the latter case, the proximal signals for regulation are related to photoperiod. Three diverse models, the mouse, the mustelid carnivores and the wallaby have been studied in detail. From these studies it can be discerned that, although the endocrine cues responsible for induction of diapause and re-initiation of development vary widely between species, there are a number of commonalities. Evidence to date indicates that the uterus exercises the proximal regulatory influence over whether an embryo enters into and when it exits from diapause. Some factors have been identified that appear crucial to this regulation, in particular, the polyamines. Recent studies indicate that diapause can be induced in species where it does not exist in nature. This suggests that the potential for diapause in mammals to be due to a single evolutionary event, to which control mechanisms adapted when the trait was beneficial to reproductive success. Further work at the molecular, cellular and organismic levels will be required before the physiological basis of diapause is resolved.
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“Animals regulate development and reproduction according to environmental cues such as season, temperature, moon phase, and food availability (1–5).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in Platynereis (2020) · cites this paper as [4]
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Cites
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
Stewart, C. L., Kašpar, P., Brunet, L. J., Bhatt, H., Gadi, I. K., Köntgen, F., & Abbondanzo, S. J. (1992) · Nature · doi:10.1038/359076a0 · Cited by 2,033
Mechanisms of implantation: strategies for successful pregnancy
Cha, J., Sun, X., & Dey, S. K. (2012) · Nature Medicine · doi:10.1038/nm.3012 · Cited by 1,391
Molecular Cues to Implantation
Dey, S. K., Lim, H. J., Das, S. K., Reese, J., Paria, B. C., Daikoku, T., & Wang, H. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0020 · Cited by 1,120
A perspective of polyamine metabolism
WALLACE, H. M., Fraser, A. V., & Hughes, A. D. (2003) · Biochemical Journal · doi:10.1042/bj20031327 · Cited by 933
Reproductive Physiology of Marsupials
Tyndale-Biscoe, H. H., & Renfree, M. B. (1987) · Cambridge University Press eBooks · doi:10.1017/cbo9780511623493 · Cited by 762
Das, S., Wang, X., Paria, B. C., Damm, D. L., Abraham, J. A., Klagsbrun, M., Andrews, G. K., & Dey, S. K. (1994) · Development · doi:10.1242/dev.120.5.1071 · Cited by 563
Paria, B. C., Huet, Y. M., & Dey, S. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10159 · Cited by 518
Bhatt, H., Brunet, L. J., & Stewart, C. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11408 · Cited by 517
Deciphering the Cross-Talk of Implantation: Advances and Challenges
Paria, B. C., Reese, J., Das, S. K., & Dey, S. K. (2002) · Science · doi:10.1126/science.1071601 · Cited by 486
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Rehman, S. K., Haynes, J., Collignon, E., Brown, K. R., Wang, Y., Nixon, A. M. L., Bruce, J. P., Wintersinger, J. A., Singh Mer, A., Lo, E. B. L., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.018 · Cited by 495
Metabolic features of chronic fatigue syndrome
Naviaux, R. K., Naviaux, J. C., Li, K., Bright, A. T., Alaynick, W. A., Wang, L., Baxter, A., Nathan, N., Anderson, W. H., & Gordon, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607571113 · Cited by 405
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Bulut-Karslioglu, A., Biechele, S., Jin, H., Macrae, T. A., Hejna, M., Gertsenstein, M., Song, J. S., & Ramalho-Santos, M. (2016) · Nature · doi:10.1038/nature20578 · Cited by 283
Dhimolea, E., Simoes, R. D. M., Kansara, D. N., Al’Khafaji, A. M., Bouyssou, J., Weng, X., Sharma, S., Raja, J., Awate, P., Shirasaki, R., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.12.002 · Cited by 268
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities
Russo, M., Chen, M., Mariella, E., Peng, H., Rehman, S. K., Sancho, E., Sogari, A., Toh, T. S., Balaban, N. Q., Batlle, E., et al. (2024) · Nature Reviews Cancer · doi:10.1038/s41568-024-00737-z · Cited by 210
Metadata
- Authors
- Fenelon, J. C., Banerjee, A., & Murphy, B. D.
- Affiliations
- Université de Montréal (CA)
- Venue
- The International Journal of Developmental Biology
- Publisher
- EHU Press
- Published
- 2014
- Volume
- 58
- Issue
- 2-3-4
- Pages
- 163-174
- ISSN
- 0214-6282 (ISSN-L)
- OpenAlex
- W1976804823
- Cited by
- 147
- References
- 144
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 17 · 2023: 11 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 14 · 2018: 8 · 2017: 16 · 2016: 10 · 2015: 6 · 2014: 1
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Keywords
- delayed implantation, facultative diapause, photoperiod, uterus, polyamines, wallabies, mice
- MeSH terms
- Animals, Blastocyst, Embryo, Mammalian, Female, Humans, Embryo Implantation, Delayed, Reproduction, Uterus, Embryonic Development, Mice
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