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Liver Fibrosis Helps to Distinguish Autoimmune Hepatitis from DILI with Autoimmune Features: A Review of Twenty Cases
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A limited number of studies comparing liver histology between DI-ALH and AIH have been undertaken.
“A limited number of studies comparing liver histology between DI-ALH and AIH have been undertaken.”
From Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023) · cites this paper as [48]
The microscopic findings that might help to discriminate between DI-ALH and AIH are largely unknown, except for advanced fibrosis (i.e., cirrhosis), which is observed only in AIH, but not DI-ALH.
“The microscopic findings that might help to discriminate between the two conditions are largely unknown, except for advanced fibrosis (i.e., cirrhosis), which is observed only in AIH, but not DI-ALH.”
From Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023) · cites this paper as [48]
Whilst a greater degree of fibrosis has been reported in AIH, this may be a reflection of disease chronicity rather than reflective of aetiology.
“Whilst a greater degree of fibrosis has been reported in AIH,14,16,48 this may be a reflection of disease chronicity rather than reflective of aetiology.”
From Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023) · cites this paper as [48]
Treatment decisions are often based on experience gained from case reports or expert opinion.
“Treatment decisions are often based on experience gained from case reports or expert opinion.”
From Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023) · cites this paper as [48]
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Research works printed but not linked: 16
- Webb, 2018, Cellular and molecular mechanisms of autoimmune hepatitis, Annu Rev Pathol, 13, 247, 10.1146/annurev-pathol-020117-043534 · DOI
- deLemos, 2014, Drug-induced liver injury with autoimmune features, Semin Liver Dis, 34, 194, 10.1055/s-0034-1375959 · DOI
- de Boer, 2017, Features of autoimmune hepatitis in patients with drug-induced liver injury, Clin Gastroenterol Hepatol, 15, 103, 10.1016/j.cgh.2016.05.043 · DOI · Paper page
- Heurgué-Berlot, 2011, Drug-induced autoimmune-like hepatitis: a case of chronic course after drug withdrawal, Dig Dis Sci, 56, 2504, 10.1007/s10620-011-1786-8 · DOI
- Czaja, 2011, Drug-induced autoimmune-like hepatitis, Dig Dis Sci, 56, 958, 10.1007/s10620-011-1611-4 · DOI · Paper page
- Manns, 2010, Diagnosis and management of autoimmune hepatitis, Hepatology, 51, 2193, 10.1002/hep.23584 · DOI · Paper page
- Suzuki, 2011, The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury, Hepatology, 54, 931, 10.1002/hep.24481 · DOI · Paper page
- Scheuer, 1991, Classification of chronic viral hepatitis: a need for reassessment, J Hepatol, 13, 372, 10.1016/0168-8278(91)90084-O · DOI
- Ruifrok, 2001, Quantification of histochemical staining by color deconvolution, Anal Quant Cytol Histol, 23, 291
- Chen, 2017, A convenient method for quantifying collagen fibers in atherosclerotic lesions by ImageJ software, Int J Clin Exp Med, 10, 14904
- Ghonaim, 2005, Autoantibodies in chronic liver disease, Egypt J Immunol, 12, 101
- Fujiwara, 2011, Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group criteria in acute-onset autoimmune hepatitis, Liver Int, 31, 1013, 10.1111/j.1478-3231.2011.02524.x · DOI
- Kleiner, 2014, Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations, Hepatology, 59, 661, 10.1002/hep.26709 · DOI · Paper page
- Hernandez-Gea, 2011, Pathogenesis of liver fibrosis, Annu Rev Pathol, 6, 425, 10.1146/annurev-pathol-011110-130246 · DOI · Paper page
- Björnsson, 2010, Drug-induced autoimmune hepatitis: clinical characteristics and prognosis, Hepatology, 51, 2040, 10.1002/hep.23588 · DOI · Paper page
- Balitzer, 2017, Autoimmune hepatitis: review of histologic features included in the simplified criteria proposed by the international autoimmune hepatitis group and proposal for new histologic criteria, Mod Pathol, 30, 773, 10.1038/modpathol.2016.267 · DOI
Cited by
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AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Fontana, R. J., Liou, I., Reuben, A., Suzuki, A., Fiel, M. I., Lee, W., & Navarro, V. (2023) · Hepatology · doi:10.1002/hep.32689 · Cited by 340
Andrade, R. J., Aithal, G. P., de Boer, Y. S., Liberal, R., Gerbes, A., Regev, A., Terziroli Beretta-Piccoli, B., Schramm, C., Kleiner, D. E., De Martin, E., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.04.033 · Cited by 166
Metadata
- Authors
- Febres-Aldana, C. A., Alghamdi, S., Krishnamurthy, K., & Poppiti, R. J.
- Venue
- Journal of Clinical and Translational Hepatology
- Publisher
- Xia & He Publishing
- Published
- 2019-01-09
- Volume
- 7
- Issue
- X
- Pages
- 1-6
- ISSN
- 2225-0719
- 2310-8819
- PMC
- PMC6441645
- Cited by
- 25
- References
- 0
- Language
- en
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