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Assessing fluoride concentration uniformity and fluoride release from three varnishes
Abstract
Background The authors investigated the fluoride content uniformity of three commercial fluoride varnishes, as well as their fluoride-release behaviors. Methods The authors examined 20 doses from each of two tubes of Duraphat (Colgate-Palmolive Co., New York) and Duraflor (Pharmascience Inc., Montreal), and 20 doses of individually packaged 0.25-milliliter and 0.40-mL units of CavityShield (OMNII Oral Pharmaceuticals, West Palm Beach, Fla.). Part of the dose was dissolved in chloroform, followed by fluoride extraction with distilled water. The authors painted the remaining varnish from five predetermined doses from each group onto plastic substrates for examination of fluoride release. Fluoride concentrations in the solutions were measured with a fluoride-selective ion electrode. Results One-way analysis of variance showed statistically significant differences between varnish groups. The fluoride content was more uniform in Duraphat and CavityShield than it was in Duraflor. The fluoride release profiles in terms of percentage of total fluoride released over time were different among different groups of varnishes and were similar among samples from the same test group. The authors found that Duraflor released consistently more fluoride in artificial saliva than did the other two varnishes. Conclusions Fluoride content can vary between doses dispensed from the same tube. Uniformity also varies between different varnishes and affects the retention of fluoride in the varnish. Cli…
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“Shen et al.31 found MI Varnish's fluoride ion reached peak release at 24 hours, with nearly full release by 48 hours.”
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Research works printed but not linked: 16
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Cited by
Sorted by citations
Fluoride varnishes for preventing dental caries in children and adolescents
Marinho, V. C., Worthington, H. V., Walsh, T., & Clarkson, J. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002279.pub2 · Cited by 1,022
Baidya, D., Pathivada, L., Garg, N., Karthik, K. M., Jain, A. K., & Bhyri, P. (2026) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-3470
Metadata
- Authors
- SHEN, C., & AUTIO-GOLD, J.
- Venue
- The Journal of the American Dental Association
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 133
- Issue
- 2
- Pages
- 176-182
- ISSN
- 0002-8177
- Cited by
- 42
- References
- 0
- Language
- en
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