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Cited by 316Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCognitive Abilities and Testing

Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer's Disease, and Dementia: From FINGER to World-Wide FINGERS

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Rosenberg, A., Mangialasche, F., Ngandu, T., Solomon, A., Kivipelto, Miia·2020·The Journal of Prevention of Alzheimer's Disease
DOI 10.14283/jpad.2019.41PMC PMC7222931
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Abstract

Alzheimer's disease (AD) and dementia are a global public health priority, and prevention has been highlighted as a pivotal component in managing the dementia epidemic. Modifiable risk factors of dementia and AD include lifestyle-related factors, vascular and metabolic disorders, and psychosocial factors. Randomized controlled clinical trials (RCTs) are needed to clarify whether modifying such factors can prevent or postpone cognitive impairment and dementia in older adults. Given the complex, multifactorial, and heterogeneous nature of late-onset AD and dementia, interventions targeting several risk factors and mechanisms simultaneously may be required for optimal preventive effects. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is the first large, long-term RCT to demonstrate that a multidomain lifestyle-based intervention ameliorating vascular and lifestyle-related risk factors can preserve cognitive functioning and reduce the risk of cognitive decline among older adults at increased risk of dementia. To investigate the multidomain intervention in other populations and diverse cultural and geographical settings, the World-Wide FINGERS (WW-FINGERS) network was recently launched (https://alz.org/wwfingers). Within this network, new FINGER-type trials with shared core methodology, but local culture and context-specific adaptations, will be conducted in several countries. The WW-FINGERS initiative facilitates international collaborations, provides a platform for testing multidomain strategies to prevent cognitive impairment and dementia, and aims at generating high-quality scientific evidence to support public health and clinical decision-making. Furthermore, the WW-FINGERS network can support the implementation of preventive strategies and translation of research findings into practice.

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  • Research shows a positive correlation between increased physical activity, cognitive training, improved nutrition, and slowing cognitive and functional decline and intensity of BPSD.

    “Indeed, research shows a positive correlation between increased physical activity, cognitive training, improved nutrition, and slowing cognitive and functional decline and intensity of BPSD.”

    From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [168]

    The section on large multidomain lifestyle-based interventions reports that an intervention involving physical activity, cognitive training, and nutrition improved cognitive outcomes, lowered the risk of cognitive decline, and supported daily functioning in older at-risk adults. The passages do not report an effect on the intensity of behavioral and psychological symptoms of dementia (BPSD), so that part of the claim is unsupported. (LLM, conf=0.86)

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References 64 · Cited by 316

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Authors
Rosenberg, A., Mangialasche, F., Ngandu, T., Solomon, A., & Kivipelto, M.
Affiliations
  • Karolinska University Hospital (SE)
  • Stockholm University (SE)
  • Finnish Institute for Health and Welfare (FI)
  • University of Eastern Finland (FI)
Corresponding author
Kivipelto, Miia
ORCID
Venue
The Journal of Prevention of Alzheimer's Disease
Publisher
Elsevier BV
Published
2020-01
Volume
7
Issue
1
Pages
29-36
ISSN
2274-5807 (ISSN-L)
DOI
10.14283/jpad.2019.41
PMC
PMC7222931
OpenAlex
W2979733507
Cited by
316
References
64
Citations by year
2026: 34 · 2025: 61 · 2024: 53 · 2023: 53 · 2022: 53 · 2021: 45 · 2020: 17
FWCI
30.65
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Prevention of Alzheimer s Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
  • WOS
Funders
  • Suomen Lääketieteen Säätiö
  • Stichting af Jochnick Foundation
  • EU Joint Programme – Neurodegenerative Disease Research
  • Academy of Finland (319318, 317465, 287490, 278457, 291803, 305810)
  • Suomen Kulttuurirahasto
  • Juho Vainion Säätiö
  • Karolinska Institutet
  • Knut och Alice Wallenbergs Stiftelse
  • Vetenskapsrådet (529‐2014‐7503, 2017-06105)
  • Pohjois-Savon Rahasto
  • Center for Innovative Medicine
  • H2020 European Research Council (804371)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
Alzheimer's disease, dementia prevention, cognitive impairment, multidomain intervention, vascular risk factors, modifiable risk factors, cognitive decline, older adults, FINGER trial, international cooperation, contextual adaptation, research translation
MeSH terms
Alzheimer Disease, Dementia, Female, Humans, International Cooperation, Life Style, Male, Risk Factors, Global Health, Randomized Controlled Trials as Topic, Cognitive Dysfunction

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