An Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome

Brandt, Lawrence J.; Chey, William D.; Foxx-Orenstein, Amy E.; Quigley, Eamonn M.M.; Schiller, Lawrence R.; Schoenfeld, Philip S.; Spiegel, Brennan M.; Talley, Nicholas J.; Moayyedi, Paul

doi:10.14309/00000434-200901001-00002

Cited by 225Gastrointestinal motility and disordersInfant Health and DevelopmentGut microbiota and health

An Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome

Brandt, Lawrence J., Chey, William D., Foxx-Orenstein, Amy E., Quigley, Eamonn M.M., Schiller, Lawrence R., Schoenfeld, Philip S., Spiegel, Brennan M., Talley, Nicholas J. +1 more·2009·American Journal of Gastroenterology

DOI 10.14309/00000434-200901001-00002

Open this paper in CoChat — free account

Abstract

Section 2.1 Methodology for systematic reviews of irritable bowel syndrome therapy, levels of evidence, and grading of recommendations We have conducted a series of systematic reviews on the diagnostic criteria, the value of diagnostic tests, and the efficacy of therapy in IBS. We also performed a narrative review of the epidemiology of IBS. There have been several systematic reviews of therapy for IBS (1-5), but these either have not quantitatively combined the data into meta-analyses (1-3) or have inaccuracies in applying eligibility criteria and data extraction (4,5). We have, therefore, repeated all systematic reviews of IBS and synthesized the data where appropriate. Systematic review methodology For all reviews, we evaluated manuscripts that studied adults using any definition of IBS. This included a clinician-defined diagnosis, Manning criteria (6), the Kruis score (7), or Rome I (8), II (9), or III (10) criteria. For reviews of diagnostic tests, we included case series and case-control studies that evaluated serologic tests for celiac sprue (anti-gliadin, anti-endomysial, and tissue transglutaminase antibodies), lactose hydrogen breath tests, and tests for small bowel bacterial overgrowth (lactulose and glucose hydrogen breath test or jejunal aspirates). For reviews of therapies of IBS, we included only parallel group RCTs comparing active intervention with either placebo or no therapy. The following treatments were considered: Diet Fiber, bulking agents, and laxatives Antispasmodics and Peppermint Oil Antidiarrheal agents Antibiotic therapy Probiotic therapy 5HT3 antagonists 5HT4 agonists Selective C-2 chloride channel activators (Lubiprostone) Antidepressants Psychological therapies Herbal therapies and acupuncture Emerging therapies Subjects needed to be followed up for at least one week. The trial needed to include one or more of the following outcome measures: Global assessment of IBS cure or improvement Abdominal pain cure or improvement Global IBS symptom or abdominal pain scores Search strategy for identification of studies Medline (1966-June 2008), Embase (1988-June 2008), and the Cochrane Controlled Trials Register (Issue 2, 2008) electronic databases were searched. An example of the Medline search is given below. IBS patients were identified with the terms irritable bowel syndrome and functional diseases, colon (both as medical subject heading (MeSH) and free text terms), and IBS, spastic colon, irritable colon, and functional adj5 (adj5 is a term used by Medline for words that appear within 5 adjectives of each other) bowel (as free text terms). Studies identified from this search were combined with the following terms used to identify therapies for IBS: dietary fiber, cereals, psyllium, sterculia, karaya gum, parasympatholytics, scopolamine, trimebutine, muscarinic antagonists, and the following free text terms: bulking agent, psyllium fiber, fiber, husk, bran, ispaghula, wheat bran, spasmolytics, spasmolytic agents, antispasmodics, mebeverine, alverine, pinaverium bromide, otilonium bromide, cimetropium bromide, hyoscine butyl bromide, butylscopolamine, peppermint oil, loperamide and colpermin, serotonin antagonists, serotonin agonists, cisapride, receptors (serotonin, 5-HT3), and receptors (serotonin, 5-HT4; both as MeSH terms and free text terms), and the following free text terms: 5-HT3, 5-HT4, alosetron, cilansetron, tegaserod, and renzapride, psychotropic drugs, antidepressive agents, antidepressive agents (tricyclic), desipramine, imipramine, trimipramine, doxepin, dothiepin, nortriptyline, amitriptyline, selective serotonin re-uptake inhibitors, paroxetine, sertraline, fluoxetine, citalopram, venlafaxine, cognitive therapy, psychotherapy, behaviour therapy, relaxation techniques, and hypnosis (both as MeSH terms and free text terms), and the following free text terms: behavioral therapy, relaxation therapy, and hypnotherapy. Saccharomyces, Lactobacillus, Bifidobacterium, Escherichia coli or probiotics (MeSH and free text terms). An RCT filter was applied to the electronic searches. The searches were limited to humans. A recursive search of the bibliography of relevant articles also was conducted. DDW abstract books were hand searched between 2000 and 2008; UEGW abstract books were hand searched between 2000 and 2007. Authors of trial reports that did not give enough detail for adequate data extraction were contacted and asked to contribute full datasets. Experts in the field were contacted for leads on unpublished studies and no language restrictions were applied. Trials were assessed for risk of bias according to three characteristics: method of randomization, method of concealment of treatment allocation, and implementation of masking. In addition the of studies were according to the with a score of a and outcome data were by the and by a on was by using a were as and were to be treatment any improvement of IBS as a outcome was as the outcome this was not improvement in abdomi

Integrity signals

Registry

Crossref · 10.14309/00000434-200901001-00002

Cites

218 of 218 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Treatments targeting the CNS, such as antidepressants and psychological interventions, can reduce intestinal sensation/sensitivity and improve GI symptoms in patients with IBS.
“Furthermore, treatments targeting the CNS, such as antidepressants and psychological interventions, can reduce intestinal sensation/sensitivity and improve GI symptoms in patients with IBS (21, 111, 150, 165).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [21]

Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582 · see citing works
Functional Bowel Disorders
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works
Self-citation
Inflammatory Bowel Disease
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183 · see citing works
Colorectal cancer screening and surveillance: Clinical guidelines and rationale?Update based on new evidence
WINAWER, S. (2003) · Gastroenterology · doi:10.1053/gast.2003.50044 · Cited by 2,143 · see citing works
Prevalence of Celiac Disease in At-Risk and Not-At-Risk Groups in the United States
Fasano, A., Berti, I., Gerarduzzi, T., Not, T., Colletti, R. B., Drago, S., Elitsur, Y., Green, P. H. R., Guandalini, S., Hill, I. D., et al. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.3.286 · Cited by 1,692 · see citing works
The serotonin signaling system: from basic understanding to drug development for functional GI disorders
Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563 · see citing works
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Self-citation
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404 · see citing works
Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome
Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799 · see citing works
Self-citation
The impact of irritable bowel syndrome on health-related quality of life
Gralnek, I. M., Hays, R. D., Kilbourne, A., Naliboff, B., & Mayer, E. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.16484 · Cited by 781 · see citing works
Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780 · see citing works
Alteration of Intestinal Microflora Is Associated With Reduction in Abdominal Bloating and Pain in Patients With Irritable Bowel Syndrome
Nobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653 · see citing works
Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders 1 1This study was registered with ClinicalTrials.gov (trial registry no. NCT00006157).
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness
Thomas, J., Karver, S. B., Cooney, G. A., Chamberlain, B. H., Watt, C. K., Slatkin, N. E., Stambler, N., Kremer, A. B., & Israel, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707377 · Cited by 589 · see citing works
A placebo-controlled trial of prucalopride for severe chronic constipation
Camilleri, M., Kerstens, R., Rykx, A., & Vandeplassche, L. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800670 · Cited by 576 · see citing works
Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial
Camilleri, M., Northcutt, A. R., Kong, S., Dukes, G. E., McSorley, D., & Mangel, A. W. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02033-x · Cited by 551 · see citing works
CONTROLLED TRIAL OF HYPNOTHERAPY IN THE TREATMENT OF SEVERE REFRACTORY IRRITABLE-BOWEL SYNDROME
Whorwell, P. J., Prior, A., & Faragher, E. B. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92793-4 · Cited by 537 · see citing works
Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial
Atkinson, W., Sheldon, T. A., Shaath, N., & Whorwell, P. J. (2004) · Gut · doi:10.1136/gut.2003.037697 · Cited by 534 · see citing works
Food-Related gastrointestinal symptoms in the irritable bowel syndrome
Simrén, M., Månsson, A., Langkilde, A. M., Svedlund, J., Abrahamsson, H., Bengtsson, U., & Björnsson, E. S. (2001) · Digestion · doi:10.1159/000051878 · Cited by 529 · see citing works
A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome
Niedzielin, K., Kordecki, H., & Birkenfeld, B. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200110000-00004 · Cited by 506 · see citing works
Small intestinal bacterial overgrowth in patients with irritable bowel syndrome
Posserud, I., Stotzer, P.-O., Björnsson, E. S., Abrahamsson, H., & Simrén, M. (2007) · Gut · doi:10.1136/gut.2006.108712 · Cited by 499 · see citing works
Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact
Hungin, A. P. S., Chang, L., Locke, G. R., Dennis, E. H., & Barghout, V. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02463.x · Cited by 494 · see citing works
A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea‐predominant irritable bowel syndrome
Kim, H. J., Camilleri, M., Mckinzie, S., Lempke, M. B., Burton, D. D., Thomforde, G. M., & Zinsmeister, A. R. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01543.x · Cited by 468 · see citing works
The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowel Syndrome: A Randomized Trial
Pimentel, M., Park, S., Mirocha, J., Kane, S. V., & Kong, Y. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-8-200610170-00004 · Cited by 466 · see citing works
Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
Jackson, J. L., O’Malley, P. G., Tomkins, G., Balden, E., Santoro, J., & Kroenke, K. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00299-5 · Cited by 464 · see citing works
Tegaserod, a 5‐HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
Müller-Lissner, S. A., Fumagalli, I. A. L., Bardhan, K. D., Pace, F., Pecher, E., Nault, B., & Rüegg, P. C. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01094.x · Cited by 462 · see citing works
A controlled trial of psychological treatment for the irritable bowel syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90215-7 · Cited by 461 · see citing works
Medical costs in community subjects with irritable bowel syndrome
Talley, N. J., Gabriel, S. E., Harmsen, W. S., Zinsmeister, A. R., & Evans, R. W. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90738-6 · Cited by 460 · see citing works
Self-citation
Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
Costabile, A., Klinder, A., Fava, F., Napolitano, A., Fogliano, V., Leonard, C., Gibson, G. R., & Tuohy, K. M. (2008) · British Journal of Nutrition · doi:10.1017/s0007114507793923 · Cited by 444 · see citing works
The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome
Creed, F., Fernandes, L., Guthrie, E., Palmer, S., Ratcliffe, J., Read, N., Rigby, C., Thompson, D., & Tomenson, B. (2003) · Gastroenterology · doi:10.1053/gast.2003.50055 · Cited by 443 · see citing works
Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease
Tibble, J. A., Sigthorsson, G., Foster, F., Forgács, I., & Bjarnason, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.34755 · Cited by 437 · see citing works
Treatment of Irritable Bowel Syndrome With Chinese Herbal Medicine
Bensoussan, A., Talley, N. J., Hing, M. C., Menzies, R. G., Guo, A., & Ngu, M. (1998) · JAMA · doi:10.1001/jama.280.18.1585 · Cited by 415 · see citing works
Self-citation
A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating
Kim, H. J., Vazquez Roque, M. I., Camilleri, M., Stephens, D., Burton, D. D., Baxter, K., Thomforde, G., & Zinsmeister, A. R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00695.x · Cited by 400 · see citing works
Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care
Sanders, D. S., Carter, M. J., Hurlstone, D. P., Pearce, A., Ward, A. M., McAlindon, M. E., & Lobo, A. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06581-3 · Cited by 390 · see citing works
Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome
Fukudo, S., Nomura, T., & Hongo, M. (1998) · Gut · doi:10.1136/gut.42.6.845 · Cited by 387 · see citing works
AGA Technical Review on the Evaluation and Management of Chronic Diarrhea☆
Fine, K. D., & Schiller, L. R. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70513-5 · Cited by 376 · see citing works
Self-citation
Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota
KAJANDER, K., MYLLYLUOMA, E., RAJILIĆ‐STOJANOVIĆ, M., KYRÖNPALO, S., RASMUSSEN, M., JÄRVENPÄÄ, S., ZOETENDAL, E. G., DE VOS, W. M., VAPAATALO, H., & KORPELA, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03542.x · Cited by 367 · see citing works
Effect of a fermented milk containing <i>Bifidobacterium animalis</i> DN‐173 010 on the health‐related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double‐blind, controlled trial
GUYONNET, D., CHASSANY, O., DUCROTTE, P., PICARD, C., MOURET, M., MERCIER, C. ‐., & MATUCHANSKY, C. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03362.x · Cited by 365 · see citing works
Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5‐HT3 receptor antagonist
Camilleri, Mayer, Drossman, Heath, Dukes, McSorley, D., Kong, Mangel, A. W., & Northcutt (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00610.x · Cited by 365 · see citing works
Perceived food intolerance in subjects with irritable bowel syndrome--etiology, prevalence and consequences
Monsbakken, K. W., Vandvik, P. O., & Farup, P. G. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602367 · Cited by 364 · see citing works
A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention
KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02579.x · Cited by 361 · see citing works
The Irritable Bowel Syndrome: Long-Term Prognosis and the Physician-Patient Interaction
Owens, D. M., Nelson, D. K., & Talley, N. J. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-2-199501150-00005 · Cited by 349 · see citing works
Self-citation
Colonic Motility Abnormality in Patients With Irritable Bowel Syndrome Exhibiting Abdominal Pain and Diarrhea
Chey, W. Y., Jin, H. O., Lee, M. H., Sun, S. W., & Lee, K. Y. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03804.x · Cited by 347 · see citing works
Self-citation
A Randomized Double-Blind Placebo-Controlled Trial of Rifaximin in Patients with Abdominal Bloating and Flatulence
Sharara, A. I., Aoun, E., Abdul-Baki, H., Mounzer, R., Sidani, S., & ElHajj, I. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00458.x · Cited by 344 · see citing works
FOOD INTOLERANCE: A MAJOR FACTOR IN THE PATHOGENESIS OF IRRITABLE BOWEL SYNDROME
Jones, V. A., Shorthouse, M., McLaughlan, P., Workman, E., & Hunter, J. O. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92782-9 · Cited by 333 · see citing works
Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation
Johanson, J. F., Morton, D., Geenen, J., & Ueno, R. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01524.x · Cited by 331 · see citing works
Food intolerance and the irritable bowel syndrome.
Nanda, R., James, R., Smith, H., Dudley, C. R., & Jewell, D. P. (1989) · Gut · doi:10.1136/gut.30.8.1099 · Cited by 307 · see citing works
Health‐related quality of life among persons with irritable bowel syndrome: a systematic review
El‐Serag, H. B., Olden, K. W., & Bjorkman, D. J. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01290.x · Cited by 305 · see citing works
Irritable bowel syndrome: a little understood organic bowel disease?
Talley, N. J., & Spiller, R. E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09712-x · Cited by 304 · see citing works
Self-citation
A Randomized Controlled Clinical Trial of the Serotonin Type 3 Receptor Antagonist Alosetron in Women With Diarrhea-Predominant Irritable Bowel Syndrome
Camilleri, M., Chey, W. Y., Mayer, E. A., Northcutt, A. R., Heath, A. T., Dukes, G. E., McSorley, D., & Mangel, A. W. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.14.1733 · Cited by 302 · see citing works
Self-citation
A diagnostic score for the irritable bowel syndrome
Kruis, W., Thieme, C., Weinzierl, M., Schüßler, P., Holl, J., & Paulus, W. J. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90119-7 · Cited by 297 · see citing works
Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis
Lackner, J. M., Mesmer, C., Morley, S., Dowzer, C., & Hamilton, S. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.6.1100 · Cited by 295 · see citing works
Irritable Bowel Syndrome, Health Care Use, and Costs: A U.S. Managed Care Perspective
Longstreth, G. F., Wilson, A., Knight, K., Wong, J. B., Chiou, C. F., Barghout, V. E., Frech, F. H., & Ofman, J. J. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07296.x · Cited by 294 · see citing works
Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome
Sagami, Y., Shimada, Y., Tayama, J., Nomura, T., Satake, M., Endo, Y., Shoji, T., Karahashi, K., Hongo, M., & Fukudo, S. (2004) · Gut · doi:10.1136/gut.2003.018911 · Cited by 291 · see citing works
A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome
Tack, J. F., Broekaert, D., Fischler, B., Oudenhove, L. V., Gevers, A. M., & Janssens, J. (2006) · Gut · doi:10.1136/gut.2005.077503 · Cited by 289 · see citing works
A randomized, double‐blind, placebo‐controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation
Novick, J. S., Miner, P. B., Krause, R. A., Glebas, K., Bliesath, H., Ligozio, G., Rüegg, P. C., & Lefkowitz, M. P. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01372.x · Cited by 288 · see citing works
A primary care cross-sectional study of undiagnosed adult coeliac disease
Sanders, D. S., Patel, D., Stephenson, T. J., Ward, A. M., McCloskey, E. V., Hadjivassiliou, M., & Lobo, A. (2003) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200304000-00012 · Cited by 264 · see citing works
Irritable bowel syndrome and surgery: A multivariable analysis☆
Longstreth, G. F., & Yao, J. F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.020 · Cited by 248 · see citing works
Health-Related Quality of Life and Health Care Costs in Severe, Refractory Irritable Bowel Syndrome
Creed, F. H., Ratcliffe, J., Fernandez, L., Tomenson, B., Palmer, S., Rigby, C., Guthrie, E., Read, N., & Thompson, D. G. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00010 · Cited by 246 · see citing works
The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review
Cash, B. D., Schoenfeld, P., & Chey, W. D. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07027.x · Cited by 242 · see citing works
Self-citation
Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
Delvaux, M., Louvel, D., Mamet, J. ‐., Campos‐Oriola, R., & Frexinos, J. (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00375.x · Cited by 236 · see citing works
Irritable Bowel Syndrome: A 10-Yr Natural History of Symptoms and Factors That Influence Consultation Behavior
Ford, A. C., Forman, D., Bailey, A. G., Axon, A. T. R., & Moayyedi, P. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01740.x · Cited by 233 · see citing works
Self-citation
SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents
Cuppoletti, J., Malinowska, D. H., Tewari, K. P., Li, Q., Sherry, A. M., Patchen, M. L., & Ueno, R. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00528.2003 · Cited by 231 · see citing works
An Asia-Pacific, double blind, placebo controlled, randomised study to evaluate the efficacy, safety, and tolerability of tegaserod in patients with irritable bowel syndrome
Kellow, J. E., Lee, O. Y., Chang, F. Y., Thongsawat, S., Mazlam, M. Z., Yuen, H., Gwee, K., Bak, Y., Jones, J., & Wagner, A. (2003) · Gut · doi:10.1136/gut.52.5.671 · Cited by 230 · see citing works
Meta‐analysis: the treatment of irritable bowel syndrome
Pantoflickova, D., Michetti, P., Fried, M., Beglinger, C., & Blum, A. L. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02267.x · Cited by 222 · see citing works
Treatment of irritable bowel syndrome with herbal preparations: results of a double‐blind, randomized, placebo‐controlled, multi‐centre trial
Madisch, A., Holtmann, G., Plein, K., & Hotz, J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01859.x · Cited by 216 · see citing works
Influence of antidepressants on whole gut and orocaecal transit times in health and irritable bowel syndrome
GORARD, D. A., LIBBY, G. W., & FARTHING, M. J. G. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00273.x · Cited by 211 · see citing works
Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: A prospective, randomized trial
Liu, J.-H., Chen, G., Yeh, H., Huang, C.-K., & Poon, S. (1997) · Journal of Gastroenterology · doi:10.1007/bf02936952 · Cited by 210 · see citing works
Utilization of colonoscopy in the United States: results from a national consortium
Lieberman, D. A., Holub, J. L., Eisen, G. M., Kraemer, D. F., & Morris, C. D. (2005) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.06.037 · Cited by 209 · see citing works
Peppermint oil (Mintoil®) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial
CAPPELLO, G., Spezzaferro, M., Grossi, L., Manzoli, L., & Marzio, L. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.02.006 · Cited by 207 · see citing works
The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: A double blind, randomized, placebo-controlled study
Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70039-1 · Cited by 206 · see citing works
Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation
Johanson, J. F., Drossman, D. A., Panas, R. M., Wahle, A., & Ueno, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03629.x · Cited by 205 · see citing works
Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth
Nucera, G., Gabrielli, M., Lupascu, A., Lauritano, E. C., Santoliquido, A., Cremonini, F., Cammarota, G., Tondi, P., Pola, P., Gasbarrini, G., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02493.x · Cited by 204 · see citing works
Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: Baseline results from logic (longitudinal outcomes study of gastrointestinal symptoms in Canada), a naturalistic study
Paré, P., Gray, J. R., Lam, S., Balshaw, R. F., Khorasheh, S., Barbeau, M., Kelly, S., & McBurney, C. R. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.10.010 · Cited by 199 · see citing works
Clinical Determinants of Health-Related Quality of Life in Patients With Irritable Bowel Syndrome
Spiegel, B. M. R., Gralnek, I. M., Bolus, R. R., Chang, L., Dulai, G. S., Mayer, E. A., & Naliboff, B. D. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.16.1773 · Cited by 198 · see citing works
Self-citation
Paroxetine to Treat Irritable Bowel Syndrome Not Responding to High-Fiber Diet: A Double-Blind, Placebo-Controlled Trial
Tabas, G., Beaves, M., Wang, J., Friday, P., Mardini, H. E., & Arnold, G. L. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04127.x · Cited by 192 · see citing works
The efficacy of ATCC 55730 in the treatment of patients with irritable bowel syndrome—a double blind, placebo-controlled, randomized study
NIV, E., NAFTALI, T., HALLAK, R., & VAISMAN, N. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.06.001 · Cited by 191 · see citing works
Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome
Lembo, T., Wright, R. A., Bagby, B., Decker, C., Gordon, S., Jhingran, P. M., & Carter, E. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04128.x · Cited by 191 · see citing works
Cognitive behaviour therapy in addition to antispasmodic treatment for irritable bowel syndrome in primary care: randomised controlled trial
Kennedy, T., Jones, R. H., Darnley, S., Seed, P. T., Wessely, S. C., & Chalder, T. (2005) · BMJ · doi:10.1136/bmj.38545.505764.06 · Cited by 190 · see citing works
Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case–control study in irritable bowel syndrome
Lupascu, A., Gabrielli, M., Lauritano, E. C., Scarpellini, E., Santoliquido, A., Cammarota, G., Flore, R. A., Tondi, P., POLA, P., Gasbarrini, G. B., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02690.x · Cited by 186 · see citing works
A controlled comparison of cognitive therapy and self-help support groups in the treatment of irritable bowel syndrome.
Payne, A., & Blanchard, E. B. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.5.779 · Cited by 186 · see citing works
Prevalence and demographics of irritable bowel syndrome: results from a large web‐based survey
Andrews, E. B., EATON, S. C., Hollis, K. A., Hopkins, J., Ameen, V. Z., Hamm, L. R., Cook, S. F., Tennis, P. S., & Mangel, A. W. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02671.x · Cited by 184 · see citing works
The effect of fluoxetine in patients with pain and constipation‐predominant irritable bowel syndrome: a double‐blind randomized‐controlled study
Vahedi, H., Merat, S., RASHIDIOON, A., Ghoddoosi, A. R., & Malekzadeh, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02566.x · Cited by 181 · see citing works
Incidence of Ischemic Colitis and Serious Complications of Constipation Among Patients Using Alosetron: Systematic Review of Clinical Trials and Post-Marketing Surveillance Data
Chang, L., Chey, W. D., Harris, L., Olden, K., Surawicz, C., & Schoenfeld, P. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00459.x · Cited by 181 · see citing works
Self-citation
Patient‐perceived severity of irritable bowel syndrome in relation to symptoms, health resource utilization and quality of life
Hahn, B. A., Kirchdoerfer, L. J., Fullerton, S. C., & Mayer, E. A. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.00160.x · Cited by 178 · see citing works
Loperamide in Treatment of Irritable Bowel Syndrome—A Double-Blind Placebo Controlled Study
Lavö, B., Stenstam, M., & Nielsen, A.-L. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528709091003 · Cited by 175 · see citing works
Diagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsia
Hammer, J., Eslick, G. D., Howell, S. C., Altiparmak, E., & Talley, N. J. (2004) · Gut · doi:10.1136/gut.2003.021857 · Cited by 170 · see citing works
Self-citation
Systematic review: the efficacy of treatments for irritable bowel syndrome – a European perspective
Tack, J. F., Fried, M., Houghton, L. A., SPICAK, J., & FISHER, G. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02938.x · Cited by 169 · see citing works
Self-reported Symptoms and Medical Conditions among 11,868 Gulf War-era Veterans : The Seabee Health Study
Gray, G. C. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.11.1033 · Cited by 169 · see citing works
A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation
Tack, J. F., Müller-Lissner, S., Bytzer, P., Corinaldesi, R., Chang, L., Viegas, A., Schnekenbuehl, S., Dunger-Baldauf, C., & Rueegg, P. (2005) · Gut · doi:10.1136/gut.2005.070789 · Cited by 168 · see citing works
A Randomized Controlled Trial of Cognitive Behavior Therapy, Relaxation Training, and Routine Clinical Care for The Irritable Bowel Syndrome
Boyce, P. M., Talley, N. J., Balaam, B., Koloski, N. A., & Truman, G. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07716.x · Cited by 167 · see citing works
Self-citation
Symptomatic overlap between irritable bowel syndrome and microscopic colitis
Limsui, D., Pardi, D. S., Camilleri, M., Loftus, E. V., Kammer, P. P., Tremaine, W. J., & Sandborn, W. J. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20059 · Cited by 167 · see citing works
Small Intestinal Bacterial Overgrowth Recurrence After Antibiotic Therapy
Lauritano, E. C., Gabrielli, M., Scarpellini, E., Lupascu, A., Novi, M., Sottili, S., Vitale, G., Cesario, V., Serricchio, M., Cammarota, G., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02030.x · Cited by 161 · see citing works
A double‐blind, randomized, placebo‐controlled dose‐ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome
Bardhan, Bodemar, Geldof, Schütz, Heath, Mills, & Jacques (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00684.x · Cited by 158 · see citing works
Clinical trial: the effect of amitriptyline in patients with diarrhoea‐predominant irritable bowel syndrome
Vahedi, H., Merat, S., Momtahen, S., Kazzazi, A., GHAFFARI, N., Olfati, G., & Malekzadeh, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03633.x · Cited by 155 · see citing works
Double blind study of ispaghula in irritable bowel syndrome.
Prior, A., & Whorwell, P. J. (1987) · Gut · doi:10.1136/gut.28.11.1510 · Cited by 155 · see citing works
Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide, and ispaghula husk.
Ritchie, J. A., & Truelove, S. C. (1979) · BMJ · doi:10.1136/bmj.1.6160.376 · Cited by 152 · see citing works
A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome
Drouault-Holowacz, S., Bieuvelet, S., Burckel, A., Cazaubiel, M., Dray, X., & Marteau, P. (2008) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2007.06.001 · Cited by 151 · see citing works
Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled crossover study.
Lucey, M. R., Clark, M., Lowndes, J., & Dawson, A. M. (1987) · Gut · doi:10.1136/gut.28.2.221 · Cited by 151 · see citing works
Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?
Raine, R., Haines, A., Sensky, T., Hutchings, A., Larkin, K., & Black, N. (2002) · BMJ · doi:10.1136/bmj.325.7372.1082 · Cited by 150 · see citing works
Loperamide Treatment of the Irritable Bowel Syndrome
Hovdenak, N. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528709091004 · Cited by 149 · see citing works
Long-Term Safety and Efficacy of Alosetron in Women with Severe Diarrhea-Predominant Irritable Bowel Syndrome
Chey, W. D., Chey, W. Y., Heath, A. T., Dukes, G. E., Carter, E. G., Northcutt, A. R., & Ameen, V. Z. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30509.x · Cited by 149 · see citing works
Self-citation
Two controlled evaluations of multicomponent psychological treatment of irritable bowel syndrome
Blanchard, E. B., Schwarz, S. P., Suls, J. M., Gerardi, M. A., Scharff, L., Greene, B., Taylor, A. E., Berreman, C. F., & Malamood, H. S. (1992) · Behaviour Research and Therapy · doi:10.1016/0005-7967(92)90141-3 · Cited by 148 · see citing works
Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review
Park, M., & Camilleri, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00745.x · Cited by 148 · see citing works
The treatment of irritable bowel syndrome with hypnotherapy
Galovski, T. E., & Blanchard, E. B. (1998) · Applied Psychophysiology and Biofeedback · doi:10.1023/a:1022209631047 · Cited by 147 · see citing works
Oral Cromolyn Sodium in Comparison with Elimination Diet in the Irritable Bowel Syndrome, Diarrheic Type Multicenter Study of 428 Patients
Stefanini, G. F., Saggioro, A., Alvisi, V., Angelini, G., Capurso, L., Lorenzo, G. D., Dobrilla, G., Dodero, M. C. R., Galimberti, M., Gasbarrini, A., et al. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509089786 · Cited by 147 · see citing works
Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: A cost-effectiveness analysis☆
Spiegel, B. M. R., DeRosa, V. P., Gralnek, I. M., Wang, V. C., & Dulai, G. S. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.012 · Cited by 146 · see citing works
Self-citation
Discrepancies Between Reported Food Intolerance and Sensitization Test Findings in Irritable Bowel Syndrome Patients
Dainese, R., Galliani, E., Lazzari, F. D., Leo, V. D., & Naccarato, R. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01226.x · Cited by 143 · see citing works
Relaxation training as a treatment for irritable bowel syndrome
Blanchard, E. B., Greene, B., Scharff, L., & Schwarz, S. P. (1993) · Applied Psychophysiology and Biofeedback · doi:10.1007/bf00999789 · Cited by 142 · see citing works
Cognitive therapy for irritable bowel syndrome.
Greene, B., & Blanchard, E. B. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.3.576 · Cited by 140 · see citing works
A Dose-Ranging, Phase II Study of the Efficacy and Safety of Alosetron in Men with Diarrhea-Predominant IBS
Chang, L., Ameen, V. Z., Dukes, G. E., McSorley, D., Carter, E. G., & Mayer, E. A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40365.x · Cited by 139 · see citing works
Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome
Mangel, A. W., Bornstein, J. D., Hamm, L. R., Buda, J. J., Wang, J., Irish, W. D., & Urso, D. M. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03730.x · Cited by 136 · see citing works
Treatment of the Irritable Bowel Syndrome with Bentyl® (Dicyclomine Hydrochloride)
Page, J. G., & Dirnberger, G. M. (1981) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-198106000-00009 · Cited by 135 · see citing works
Coeliac disease presenting with symptoms of irritable bowel syndrome
Shahbazkhani, B., Forootan, M., Merat, S., Akbari, M. R., Nasseri‐Moghaddam, S., Vahedi, H., & Malekzadeh, R. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01666.x · Cited by 132 · see citing works
Alosetron, a 5‐HT <sub>3</sub> receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers
Houghton, Foster, & Whorwell (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00762.x · Cited by 132 · see citing works
A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea-Predominant Irritable Bowel Syndrome
Róka, R., Rosztoczy, A. I., Leveque, M., Izbéki, F., Nagy, F. T., Molnár, T., Lonovics, J., Villar, R. G., Fioramonti, J., Wittmann, T., et al. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.004 · Cited by 132 · see citing works
Antidepressant Therapy (Imipramine and Citalopram) for Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo-Controlled Trial
Talley, N. J., Kellow, J. E., Boyce, P. M., Tennant, C., Huskic, S., & Jones, M. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9830-4 · Cited by 130 · see citing works
Self-citation
FOOD HYPERSENSITIVITY IN IRRITABLE BOWEL SYNDROME
Bentley, S., Pearson, D., & Rix, K. B. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90285-4 · Cited by 130 · see citing works
Alosetron relieves pain and improves bowel function compared with mebeverine in female nonconstipated irritable bowel syndrome patients
Jones, Holtmann, G., Rodrigo, L., Ehsanullah, Crompton, Jacques, & Mills (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00678.x · Cited by 130 · see citing works
Rifaximin versus Other Antibiotics in the Primary Treatment and Retreatment of Bacterial Overgrowth in IBS
Yang, J., Lee, H.-R., Low, K., Chatterjee, S., & Pimentel, M. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9839-8 · Cited by 129 · see citing works
Additional Investigations Fail to Alter The Diagnosis of Irritable Bowel Syndrome in Subjects Fulfilling The Rome Criteria
Hamm, L. R., Sorrells, S. C., Harding, J., Northcutt, A. R., Heath, A. T., Kapke, G. F., Hunt, C. M., & Mangel, A. W. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01077.x · Cited by 126 · see citing works
Stress Management for Irritable Bowel Syndrome: A Controlled Trial
Shaw, G., Srivastava, E. D., Sadlier, M., Swann, P., James, J., & Rhodes, J. (2009) · Digestion · doi:10.1159/000200738 · Cited by 125 · see citing works
Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology
Forte, L. R. (1999) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00033-6 · Cited by 123 · see citing works
A multi-component treatment for irritable bowel syndrome
Neff, D. F., & Blanchard, E. B. (1987) · Behavior Therapy · doi:10.1016/s0005-7894(87)80052-7 · Cited by 119 · see citing works
Suicidal ideation in patients with irritable bowel syndrome
Miller, V., Hopkins, L., & Whorwell, P. J. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00545-2 · Cited by 119 · see citing works
Self-management for women with irritable bowel syndrome
Heitkemper, M. M., Jarrett, M. E., Levy, R. L., Cain, K. C., Burr, R. L., Feld, A., Barney, P., & Weisman, P. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00242-3 · Cited by 119 · see citing works
Utility of red flag symptom exclusions in the diagnosis of irritable bowel syndrome
WHITEHEAD, W. E., PALSSON, O. S., FELD, A. D., LEVY, R. L., VON KORFF, M., TURNER, M. J., & DROSSMAN, D. A. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02956.x · Cited by 118 · see citing works
Effect of renzapride on transit in constipation-predominant irritable bowel syndrome
Camilleri, M., McKinzie, S., Fox, J., Foxx–Orenstein, A. E., Burton, D. D., Thomforde, G. M., Baxter, K. L., & Zinsmeister, A. R. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00391-x · Cited by 118 · see citing works
Self-citation
The effect of the 5‐HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients
Mayer, E. A., Berman, S. M., Derbyshire, S. W. G., Suyenobu, B. Y., Chang, L., Fitzgerald, L., Mandelkern, M. A., Hamm, L. R., Vogt, B. A., & Naliboff, B. D. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01287.x · Cited by 117 · see citing works
A Randomized, Double-Blind, Placebo-Controlled Study to Assess Efficacy and Safety of 0.5 mg and 1 mg Alosetron in Women With Severe Diarrhea-predominant IBS
Krause, R. A., Ameen, V. Z., Gordon, S., West, M. A., Heath, A. T., Perschy, T. L., & Carter, E. G. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01282.x · Cited by 117 · see citing works
Lactose malabsorption in a population with irritable bowel syndrome: prevalence and symptoms. A case‐control study
Farup, P. G., Monsbakken, K. W., & Vandvik, P. O. (2004) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520410005405 · Cited by 116 · see citing works
CLC chloride channels and transporters: a biophysical and physiological perspective
Zifarelli, G., & Pusch, M. (2006) · Springer eBooks · doi:10.1007/112_2006_0605 · Cited by 114 · see citing works
Irritable colon and depression
Heefner, J., Wilder, R. M., & Wilson, I. D. (1978) · Psychosomatics · doi:10.1016/s0033-3182(78)70930-8 · Cited by 111 · see citing works
Treatment With Hypnotherapy Reduces the Sensory and Motor Component of the Gastrocolonic Response in Irritable Bowel Syndrome
Simrén, M., Ringström, G., Björnsson, E. S., & Abrahamsson, H. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000116964.76529.6e · Cited by 111 · see citing works
Diversity of Cl− Channels
Suzuki, M., Morita, T., & Iwamoto, T. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5336-4 · Cited by 111 · see citing works
Treating Irritable Bowel Syndrome with a Food Elimination Diet Followed by Food Challenge and Probiotics
Drisko, J., Bischoff, B., Hall, M., & McCallum, R. W. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719567 · Cited by 109 · see citing works
Comparison of the Therapeutic Effect of Wheat Bran, Mebeverine and Placebo in Patients with the Irritable Bowel Syndrome
Kruis, W., Weinzierl, M., Schüßler, P., & Holl, J. L. (2009) · Digestion · doi:10.1159/000199329 · Cited by 108 · see citing works
Single‐blind follow‐up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome
TSUCHIYA, J., BARRETO, R., OKURA, R., KAWAKITA, S., FESCE, E., & MAROTTA, F. (2004) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2004.00176.x · Cited by 108 · see citing works
Bran supplementation in the treatment of irritable bowel sgndrome
Snook, J. A., & Shepherd, H. A. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00323.x · Cited by 107 · see citing works
A double‐blind, placebo‐controlled, randomized study to evaluate the efficacy, safety and tolerability of tegaserod in patients with irritable bowel syndrome
Nyhlin, H., Bang, C. J., Elsborg, L., Silvennoinen, J. I. K., Holme, I., Rüegg, P. C., Jones, J. J., & Wagner, A. (2004) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310006748 · Cited by 106 · see citing works
The effects of relaxation response meditation on the symptoms of irritable bowel syndrome: results of a controlled treatment study
Keefer, L., & Blanchard, E. B. (2001) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(00)00078-4 · Cited by 104 · see citing works
Celiac Disease Serology in Irritable Bowel Syndrome and Dyspepsia: A Population-Based Case-Control Study
Locke, G. R., Murray, J. A., Zinsmeister, A. R., Melton, L. J., & Talley, N. J. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.4.476 · Cited by 104 · see citing works
Self-citation
Effect of asimadoline, a κ opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome
Delvaux, M. M., Beck, A., Jacob, J., Bouzamondo, H., Weber, F. T., & Frexinos, J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01922.x · Cited by 102 · see citing works
The Effect of Trimipramine in Patients with the Irritable Bowel Syndrome
Myren, J., Groth, H., Larssen, S.-E., Larsen, S., & The Multicentre Study Group (1982) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528209181108 · Cited by 101 · see citing works
Psyllium Therapy in the Irritable Bowel Syndrome
Longstreth, G. F., FOX, D. D., YOUKELES, L., FORSYTHE, A. B., & WOLOCHOW, D. A. (1981) · Annals of Internal Medicine · doi:10.7326/0003-4819-95-1-53 · Cited by 99 · see citing works
Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome
Khoshoo, V., ARMSTEAD, C., & Landry, L. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02705.x · Cited by 98 · see citing works
Systematic review: the prevalence of suicidal behaviour in patients with chronic abdominal pain and irritable bowel syndrome
Spiegel, B. M. R., Schoenfeld, P., & Naliboff, B. D. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03357.x · Cited by 98 · see citing works
Self-citation
The Association of Irritable Bowel Syndrome and Somatization Disorder
Miller, A., North, C., Clouse, R., Wetzel, R., Spitznagel, E., & Alpers, D. (2001) · Annals of Clinical Psychiatry · doi:10.3109/10401230109147126 · Cited by 98 · see citing works
Effect of dietary fiber on symptoms and rectosigmoid motility in patients with irritable bowel syndrome
Cook, I. J., Irvine, E. J., Campbell, D., Shannon, S., Reddy, S. N., & Collins, S. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91292-e · Cited by 96 · see citing works
Roles of Calcitonin Gene–Related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing and Angiogenesis
Ohno, T., Hattori, Y., Komine, R., Ae, T., Mizuguchi, S., Arai, K., Saeki, T., Suzuki, T., Hosono, K., Hayashi, I., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.001 · Cited by 95 · see citing works
“Prokinetic” Treatment of Constipation-Predominant Irritable Bowel Syndrome
Outryve, M. V., Milo, R., Toussaint, J., & Eeghem, P. V. (1991) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199102000-00012 · Cited by 95 · see citing works
Colonic Tone and Motility in Patients With Irritable Bowel Syndrome
Vassallo, M., Camilleri, M., Phillips, S. F., Steadman, C. J., Talley, N. J., Hanson, R. B., & Haddad, A. C. (1992) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60796-4 · Cited by 92 · see citing works
Self-citation
A Clinical Trial of Trimebutine (Mebutin) in Spastic Colon
Moshal, M. G., & Herron, M. (1979) · Journal of International Medical Research · doi:10.1177/030006057900700311 · Cited by 90 · see citing works
Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon
Bassil, A. K., Borman, R. A., Jarvie, E. M., McArthur‐Wilson, R. J., Thangiah, R., Sung, E., Lee, K., & Sanger, G. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.84 · Cited by 87 · see citing works
Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?
Spiegel, B. M. R., Gralnek, I. M., Bolus, R., Chang, L., Dulai, G. S., Naliboff, B., & Mayer, E. A. (2005) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.08.016 · Cited by 87 · see citing works
Self-citation
Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans
Chial, H. J., Camilleri, M., Ferber, I. J., Delgado-Aros, S., Burton, D. D., McKinzie, S., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70038-x · Cited by 84 · see citing works
CFTR Chloride Channel Drug Discovery - Inhibitors as Antidiarrheals and Activators for Therapy of Cystic Fibrosis
Verkman, A. S., Lukács, G. L., & Galietta, L. J. V. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777585148 · Cited by 84 · see citing works
Serological testing for coeliac disease in patients with symptoms of irritable bowel syndrome: a cost‐effectiveness analysis
Mein, S. M., & Ladabaum, U. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01958.x · Cited by 82 · see citing works
Visceral and cutaneous hypersensitivity in Persian Gulf war veterans with chronic gastrointestinal symptoms
Dunphy, R. C., Bridgewater, L., Price, D. D., Robinson, M. E., Zeilman, C. J., & Verne, N. G. (2003) · Pain · doi:10.1016/s0304-3959(02)00342-1 · Cited by 81 · see citing works
Prevalence, Sociodemography, and QualitLife of Older Versus Younger Patients with Irritable Bowel Syndrome: A Population-Based Study
Minocha, A., Johnson, W. D., Abell, T., & Wigington, W. C. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-3153-8 · Cited by 80 · see citing works
A controlled behavioral treatment study of Irritable Bowel syndrome
Lynch, P. M., & Zamble, E. (1989) · Behavior Therapy · doi:10.1016/s0005-7894(89)80130-3 · Cited by 78 · see citing works
The Effect of Coarse Wheat Bran in the Irritable Bowel Syndrome lA Double-Blind Cross-Over Study
Arffmann, S., Andersen, J. R., Hegnhøj, J., de Muckadell, O. B. S., Mogensen, N. B., & KRAG, E. (1985) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528509091653 · Cited by 76 · see citing works
Clinical trial: dextofisopam in the treatment of patients with diarrhoea‐predominant or alternating irritable bowel syndrome
Leventer, S. M., Raudibaugh, K., Frissora, C. L., Kassem, N. A., Keogh, J. C., PHILLIPS, J., & Mangel, A. W. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03566.x · Cited by 75 · see citing works
A Novel Treatment for Constipation-Predominant Irritable Bowel Syndrome Using Padma®Lax, a Tibetan Herbal Formula
Sallon, S., Ben‐Arye, E., Davidson, R., Shapiro, H., Ginsberg, G. M., & Ligumsky, M. (2002) · Digestion · doi:10.1159/000064936 · Cited by 75 · see citing works
Clinical Response to Tricyclic Antidepressants in Functional Bowel Disorders is not Related to Dosage
Halpert, A. D., Dalton, C. B., Diamant, N. E., Toner, B. B., Hu, Y., Morris, C. B., Bangdiwala, S. I., Whitehead, W. E., & Drossman, D. A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.30375.x · Cited by 73 · see citing works
The effect of new diagnostic criteria for irritable bowel syndrome on community prevalence estimates
Saito, Y. A., Talley, N. J., J. Melton, L., Fett, S., Zinsmeister, A. R., & Locke, G. R. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1350-1925.2003.00441.x · Cited by 72 · see citing works
Self-citation
Paraghurt for Patients with Irritable Bowel Syndrome:A Controlled Clinical Investigation from General Practice
Gade, J., & Thorn, F. (1989) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813438909103666 · Cited by 72 · see citing works
Controlled comparison of individual versus group cognitive therapy for irritable bowel syndrome
Vollmer, A., & Blanchard, E. B. (1998) · Behavior Therapy · doi:10.1016/s0005-7894(98)80016-6 · Cited by 68 · see citing works
Longterm treatment of irritable bowel syndrome with cimetropium bromide: a double blind placebo controlled clinical trial.
Dobrilla, G., Imbimbo, B. P., Piazzi, L., & Bensi, G. (1990) · Gut · doi:10.1136/gut.31.3.355 · Cited by 66 · see citing works
The Impact of Somatization on the Use of Gastrointestinal Health-Care Resources in Patients with Irritable Bowel Syndrome
Spiegel, B. M. R., Kanwal, F., Naliboff, B. D., & Mayer, E. A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00269.x · Cited by 66 · see citing works
Self-citation
Exclusion Diets in Irritable Bowel Syndrome
McKee, A. M., Prior, A., & Whorwell, P. J. (1987) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-198710000-00007 · Cited by 65 · see citing works
Randomized controlled trial of cognitive-behavioral group therapy for irritable bowel syndrome in a medical setting
Tkachuk, G. A., Graff, L. A., Martin, G. L., & Bernstein, C. N. (2003) · Journal of Clinical Psychology in Medical Settings · doi:10.1023/a:1022809914863 · Cited by 62 · see citing works
Tegaserod for Female Patients Suffering From IBS With Mixed Bowel Habits or Constipation: A Randomized Controlled Trial
Chey, W. D., Paré, P., Viegas, A., Ligozio, G., & Shetzline, M. A. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01808.x · Cited by 62 · see citing works
Self-citation
Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome
Glende, M., Morselli‐Labate, A. M., Battaglia, G., & Evangelista, S. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200212000-00008 · Cited by 61 · see citing works
Clinical trial: short‐ and long‐term benefit of relaxation training for irritable bowel syndrome
van der Veek, P. P. J., van Rood, Y. R., & Masclee, A. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03437.x · Cited by 59 · see citing works
Ispaghula therapy in irritable bowel syndrome: Improvement in overall well‐being is related to reduction in bowel dissatisfaction
Jalihal, A., & Kurian, G. P. (1990) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1990.tb01432.x · Cited by 57 · see citing works
Double‐blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome
Schütze, K., Brandstatter, G., Dragosics, B., Judmaier, G., & Hentschel, E. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.133311000.x · Cited by 57 · see citing works
Manning Criteria in Irritable Bowel Syndrome: Its Diagnostic Significance
Jeong, H., Lee, H., Yoo, B. C., & Park, S. (1993) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.1993.8.1.34 · Cited by 55 · see citing works
Calcium polycarbophil compared with placebo in irritable bowel syndrome
Toskes, P. P., Connery, K., & Ritchey, T. (1993) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1993.tb00074.x · Cited by 55 · see citing works
A Simple Score for the Identification of Patients at High Risk of Organic Diseases of the Colon in the Family Doctor Consulting Room
Bellentani, S., BALDONI, P., PETRELLA, S., Tata, C., Armocida, C., Marchegiano, P., Saccoccio, G., & Manenti, F. (1990) · Family Practice · doi:10.1093/fampra/7.4.307 · Cited by 52 · see citing works
The Symptomatic Effect of Cisapride in Patients with Irritable Bowel Syndrome and Constipation
Farup, P. G. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850166833 · Cited by 51 · see citing works
Randomised-controlled trial of a fibre supplement on the symptoms of irritable bowel syndrome
Rees, G., Davies, J., Thompson, R., Parker, M., & Liepins, P. (2005) · The Journal of the Royal Society for the Promotion of Health · doi:10.1177/146642400512500112 · Cited by 50 · see citing works
Different Autonomic Responses to Experimental Pain in IBS Patients and Healthy Controls
Tousignant‐Laflamme, Y., Goffaux, P., Bourgault, P., & Marchand, S. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000225607.56352.ce · Cited by 47 · see citing works
Breath Tests for Gastrointestinal Disease: The Real Deal or Just a Lot of Hot Air?
Saad, R. J., & Chey, W. D. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.059 · Cited by 47 · see citing works
Self-citation
Visceral hypersensitivity and intolerance symptoms in lactose malabsorption
Stefano, M. D., Miceli, E., Mazzocchi, S., Tana, P., Moroni, F., & Corazza, G. R. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00973.x · Cited by 47 · see citing works
Preliminary Study of a Self-Administered Treatment for Irritable Bowel Syndrome: Comparison to a Wait List Control Group
Sanders, K. A., Blanchard, E. B., & Sykes, M. A. (2007) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-007-9037-7 · Cited by 43 · see citing works
Managing functional bowel disorders from the top down: lessons from a well-designed treatment trial
Clouse, R. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00808-4 · Cited by 43 · see citing works
Irritable bowel syndrome
Frigerio, G., Beretta, A., Orsenigo, G., Tadeo, G., Imperiali, G., & Minoli, G. (1992) · Digestive Diseases and Sciences · doi:10.1007/bf01308166 · Cited by 43 · see citing works
Clinical trial: renzapride therapy for constipation‐predominant irritable bowel syndrome – multicentre, randomized, placebo‐controlled, double‐blind study in primary healthcare setting
GEORGE, A. M., Meyers, N. L., & Hickling, R. I. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03649.x · Cited by 42 · see citing works
Hydrogen breath test quantification and clinical correlation of lactose malabsorption in adult irritable bowel syndrome and ulcerative colitis
Sciarretta, G., Giacobazzi, G., Verri, A., Zanirato, P., Garuti, G., & Malaguti, P. (1984) · Digestive Diseases and Sciences · doi:10.1007/bf01317083 · Cited by 41 · see citing works
Patient Satisfaction With Alosetron for the Treatment of Women With Diarrhea-Predominant Irritable Bowel Syndrome
Olden, K. W., DeGarmo, R. G., Jhingran, P. M., Bagby, B., Decker, C., Markowitz, M., & Carter, E. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07111.x · Cited by 40 · see citing works
Irritable bowel syndrome: Assessment of psychological disturbance and its influence on the response to fibre supplementation
FOWLIE, S., Eastwood, M. A., & Prescott, R. J. (1992) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(92)90026-x · Cited by 40 · see citing works
Prifinium bromide in the treatment of the irritable colon syndrome
Piai, G., & Mazzacca, G. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90012-x · Cited by 40 · see citing works
Effect of tegaserod on colonic transit time in male patients with constipation‐predominant irritable bowel syndrome
Harish, K., Hazeena, K., Thomas, V., Kumar, S., Jose, T., & Narayanan, P. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04543.x · Cited by 38 · see citing works
Lubiprostone Significantly Improves Symptom Relief Rates in Adults With Irritable Bowel Syndrome and Constipation (IBS-C): Data from Two Twelve-Week, Randomized, Placebo-Controlled, Double-Blind Trials
Drossman, D. A., Chey, W. D., Panas, R. M., Wahle, A., Scott, C., & Ueno, R. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.022 · Cited by 37 · see citing works
Self-citation
Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double‐blind, randomized, placebo‐controlled trial
Mitchell, S. A., Mee, A. S., Smith, G. D., Palmer, K. R., & Chapman, R. W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01277.x · Cited by 36 · see citing works

Flagged first, then by citations

Sorted by citations

Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation
Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036 · see citing works
Self-citation
Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome
Kaptchuk, T. J., Friedlander, E., Kelley, J. M., Sanchez, M. N., Kokkotou, E., Singer, J. P., Kowalczykowski, M., Miller, F. G., Kirsch, I., & Lembo, A. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015591 · Cited by 900 · see citing works
“[11,13] Previous research has demonstrated that placebo responses in IBS are substantial and clinically significant.”
Background
Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis
Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.202 · Cited by 747 · see citing works
Self-citation
Systematic review with meta‐analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome
Ford, A. C., Harris, L. A., Lacy, B. E., Quigley, E. M. M., & Moayyedi, P. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15001 · Cited by 619 · see citing works
Self-citation
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome
Ong, D. K., Mitchell, S. B., Barrett, J. S., Shepherd, S. J., Irving, P. M., Biesiekierski, J. R., Smith, S., Gibson, P. R., & Muir, J. G. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06370.x · Cited by 583 · see citing works
Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis
Ford, A. C., Lacy, B. E., Harris, L. A., Quigley, E. M. M., & Moayyedi, P. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0222-5 · Cited by 467 · see citing works
Self-citation
Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis
Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.148 · Cited by 405 · see citing works
Self-citation
VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study
Guandalini, S., Magazzù, G., Chiaro, A., La Balestra, V., Di Nardo, G., Gopalan, S., Sibal, A., Romano, C., Canani, R. B., Lionetti, P., et al. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181ca4d95 · Cited by 273 · see citing works
Efficacy of 5-HT3 Antagonists and 5-HT4 Agonists in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis
Ford, A. C., Brandt, L. J., Young, C., Chey, W. D., Foxx-Orenstein, A. E., & Moayyedi, P. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.223 · Cited by 261 · see citing works
Self-citation
Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation
Johnston, J. M., Kurtz, C. B., MacDougall, J. E., Lavins, B. J., Currie, M. G., Fitch, D. A., O'Dea, C., Baird, M., & Lembo, A. J. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.041 · Cited by 229 · see citing works
Anxiety Is Linked to New-Onset Dyspepsia in the Swedish Population: A 10-Year Follow-up Study
Aro, P., Talley, N. J., Johansson, S.-E., Agréus, L., & Ronkainen, J. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.039 · Cited by 162 · see citing works
Self-citation
Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome
Ringel, Y., & Maharshak, N. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00207.2012 · Cited by 115 · see citing works
Relief of irritable bowel syndrome by fecal microbiota transplantation is associated with changes in diversity and composition of the gut microbiota
Huang, H. L., Chen, H. T., Luo, Q. L., Xu, H. M., He, J., Li, Y. Q., Zhou, Y. L., Yao, F., Nie, Y. Q., & Zhou, Y. J. (2019) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12756 · Cited by 89 · see citing works
Questioning the Bacterial Overgrowth Hypothesis of Irritable Bowel Syndrome: An Epidemiologic and Evolutionary Perspective
Spiegel, B. M. R. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.02.030 · Cited by 67 · see citing works
Self-citation
Intervening on cognitions and behavior in irritable bowel syndrome: A feasibility trial using PDAs
Oerlemans, S., van Cranenburgh, O., Herremans, P.-J., Spreeuwenberg, P., & van Dulmen, S. (2011) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.09.018 · Cited by 67 · see citing works
Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases
Grover, M., & Camilleri, M. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-012-0726-5 · Cited by 65 · see citing works

Authors: Brandt, L. J., Chey, W. D., Foxx-Orenstein, A. E., Quigley, E. M. M., Schiller, L. R., Schoenfeld, P. S., Spiegel, B. M., Talley, N. J., & Moayyedi, P.
Affiliations: Montefiore Medical Center (US)
Michigan Medicine (US)
Cork University Hospital (IE)
Baylor University Medical Center (US)
VA Ann Arbor Healthcare System (US)
University of California, Los Angeles (US)
Mayo Clinic (US)
McMaster University Medical Centre (CA)
Corresponding author: Brandt, Lawrence J.
ORCID: Brandt, Lawrence J.
Chey, William D.
Quigley, Eamonn M.M.
Schiller, Lawrence R.
Schoenfeld, Philip S.
Spiegel, Brennan M.
Talley, Nicholas J.
Moayyedi, Paul
Venue: American Journal of Gastroenterology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-01
Volume: 104
Pages: S8-S35
ISSN: 0002-9270 (ISSN-L)
DOI: 10.14309/00000434-200901001-00002
OpenAlex: W2978149037
Semantic Scholar: 0791e96d7a99add0b68d1353721c81d948b6c595
Cited by: 225
References: 218
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 13 · 2019: 6 · 2018: 10 · 2017: 65 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 12 · 2012: 20
FWCI: 3.48
Type: journal article
Language: en
Open access: closed
Locations: The American Journal of Gastroenterology (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: irritable bowel syndrome, IBS management, dietary fiber, bulking agents, laxatives, antispasmodic agents, peppermint oil, probiotics, 5-HT3 receptor antagonists, 5-HT4 receptor agonist, lubiprostone, antidepressants, psychotherapy, herbal medicine, acupuncture, small intestinal bacterial overgrowth, lactose intolerance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks