High-resolution esophageal manometry in myasthenia gravis
Open accessAbstract
Myasthenia gravis (MG) is an autoimmune disease that affects the postsynaptic membrane at the neuromuscular junction. In MG, antibodies bind to acetylcholine receptors inducing muscle weakness. The weakness typically increases with exercise and repetitive muscle use. Improvement of muscular weakness after rest and/or administration of anticholinesterase drugs (edrophonium) are characteristic of MG. We report a patient with unexplained dysphagia, dysphonia, and dysarthria, whose diagnosis was suggested by high-resolution esophageal motility and edrophonium infusion. We highlight the importance of dysphagia as presenting or dominant symptom in MG and review the esophageal motility findings in this rare, but treatable disorder.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Esophageal dysmotility has been documented with high-resolution manometry in myasthenia gravis.
“Although myasthenia gravis (MG) is classically characterized by fatigable skeletal muscle weakness, esophageal dysmotility has been documented with high-resolution manometry in MG (Torres-Barrera et al., 2020).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Torres-Barrera et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 21 · Cited by 6
Research works printed but not linked: 19
- [1]Hehir MK Silvestri NJ Generalized myasthenia gravis: Classification, clinical presentation, natural history, and epidemiology. Neurol Clin. 2018; 36(2): 253– 60. 29655448
- [2]Gilhus NE Myasthenia gravis. N Engl J Med. 2016; 375(26): 2570– 81. 28029925
- [3]Gwathmey KG Burns TM Myasthenia gravis. Semin Neurol. 2015; 35: 327– 39. 26502757
- [4]Gilhus NE Tzartos S Evoli A Myasthenia gravis. Nat Rev Dis Primers. 2019; 5(1): 30. 31048702
- [5]Carr AS Cardwell CR McCarron PO McConville J A systematic review of population based epidemiological studies in myasthenia gravis. BMC Neurol. 2010; 10: 46. 20565885 PMC2905354
- [6]Evoli A Myasthenia gravis: New developments in research and treatment. Curr Opin Neurol. 2017; 30(5): 464– 70. 28654435
- [7]Zisimopoulou P Brenner T Trakas N Tzartos SJ Serological diagnostics in myasthenia gravis based on novel assays and recently identified antigens. Autoimmun Rev. 2013; 12: 924– 30. 23537507
- [8]Llabrés M Molina-Martinez FJ Miralles F Dysphagia as the sole manifestation of myasthenia gravis. J Neurol Neurosurg Psychiatry. 2005; 76(9): 1297– 300. 16107373 PMC1739805
- [9]Grob D Brunner NG Namba T The natural course of myasthenia gravis and effect of therapeutic measures. Ann N Y Acad Sci. 1981; 377: 652– 69. 6951490
- [11]Mustafa MS Marshal M Ahern E Delayed diagnosis of atypical presentation of myasthenia gravis. Eur J Case Rep Intern Med. 2018; 5(2): 000785. 30756011 PMC6346934
- [12]Heldal AT Owe JF Gilhus NE Romi F Seropositive myasthenia gravis: A nationwide epidemiologic study. Neurology. 2009; 73: 150– 1. 19597135
- [13]Yang X Niu L Yang C Clinical features of laryngeal myasthenia gravis: A case series. Am J Otolaryngol. 2019; 40(2): 292– 6. 30497698
- [14]Roche JC Jarauta L Artal J Oesophageal aperistalsis in a patient with myasthenia gravis with dysphagia as a symptom of onset. Neurologia. 2011; 26(8): 503– 5. 21397992
- [15]Khan OA Campbell WW Myasthenia gravis presenting as dysphagia: Clinical considerations. Am J Gastroenterol. 1994; 89: 1083– 5. 8017368
- [16]Huang MH King KL Chien KY Esophageal manometric studies in patients with myasthenia gravis. J Thorac Cardiovasc Surg. 1988; 95(2): 281– 5. 3339894
- [17]Joshita Y Yoshida M Yoshida Y Manometric study of the pharynx and pharyngoesophageal sphincter in myasthenia gravis. Rinsho Shinkeigaku. 1990; 30(9): 944– 51. [Japanese.] 2265503
- [18]Carpenter RJ III McDonald TJ Howard FM Jr The otolaryngologic presentation of myasthenia gravis. Laryngoscope. 1979; 89(6 pt 1): 922– 8. 449537
- [19]Linke R Witt TN Tatsch K Assessment of esophageal function in patients with myasthenia gravis. J Neurol. 2003; 250(5): 601– 6. 12736742
- [20]Diamant NE Functional anatomy and physiology of the swallowing and esophageal motility. In Castell DO Richter JE (eds). The Esophagus, 5th edn Wiley-Black: Malden, MA, 2012, pp 78– 80.
- Authors
- Torres-Barrera, G., Herrera-Quiñones, G., Scharrer, S. I., Benavides-Salgado, D. E., Maldonado-Garza, H. J., & Achem, S. R.
- Affiliations
- Hospital Universitario Dr José Eleuterio Gonzalez (MX)
- Department of Gastroenterology and Endoscopy, University Hospital “Dr. José E. González”, Monterrey, Nuevo Leon, Mexico
- Mayo Clinic (US)
- Corresponding author
- Achem, Sami Rene
- Venue
- ACG Case Reports Journal
- Published
- 2020-03
- Volume
- 7
- Issue
- 3
- Pages
- e00340
- ISSN
- 2326-3253 (ISSN-L)
- PMC
- PMC7162132
- OpenAlex
- W3012443537
- Cited by
- 6
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2021: 2
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- ACG Case Reports Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- myasthenia gravis, high-resolution esophageal manometry, esophageal motility, dysphagia, edrophonium test, acetylcholine receptor antibodies, neuromuscular junction, dysarthria, dysphonia, cholinesterase inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
