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Cited by 6

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Semaglutide-Induced Liver Injury

Kalsi, Harsimran, Arora, Samneet Singh, Essilfie-Quaye, Kobina, Bassi, Raghav, Akhavan, Neeka, Perbtani, Yaseen, Brar, Tony S.·2025·ACG Case Reports Journal
DOI 10.14309/crj.0000000000001776PMC PMC12321452
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Abstract

Semaglutide, a glucagon-like peptide-1 receptor agonist widely used for managing type 2 diabetes mellitus and obesity. Reports of semaglutide-associated hepatotoxicity are exceedingly rare. We detail a case of a 44-year-old woman who developed liver injury with elevated liver enzymes after semaglutide initiation for weight management. Liver enzyme levels normalized after discontinuing the drug and worsened upon rechallenge, confirming semaglutide's potential to cause liver injury. In addition, our case study encompasses a literature review of all reported semaglutide-related drug-induced liver injury cases, highlighting the need for diligent liver function monitoring in patients on semaglutide and offering valuable insights into its hepatotoxic potential.

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Crossref · 10.14309/crj.0000000000001776

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Statistics

Figures

Figure 1. The temporal relationship between semaglutide administration and liver enzymes alanine transaminase and aspartate transaminase patterns. ALT, alanine aminotransferase; AST, aspartate aminotransferase; DILI, drug-induced liver injury.
Figure 1. The temporal relationship between semaglutide administration and liver enzymes alanine transaminase and aspartate transaminase patterns. ALT, alanine aminotransferase; AST, aspartate aminotransferase; DILI, drug-induced liver injury.CC BY-NC-ND · PubMed Central

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Research works printed but not linked: 1

  1. Alghamdi, 2024, Drug-induced autoimmune-like hepatitis and cholelithiasis associated with dulaglutide and semaglutide use in a young adult: A case report and review of literature, J Popul Ther Clin Pharmacol., 31, 674

Cited by

Metadata

Authors
Kalsi, H., Arora, S. S., Essilfie-Quaye, K., Bassi, R., Akhavan, N., Perbtani, Y., & Brar, T. S.
Affiliations
  • Department of Internal Medicine, University of Central Florida/ HCA Florida North Florida Hospital, Gainesville, FL
  • Dayanand Medical College and Hospital, Punjab, India
  • Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
  • Department of Internal Medicine, University of Florida, Gainesville, FL
ORCID
Kalsi, Harsimran
Venue
ACG Case Reports Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2025-08
Volume
12
Issue
8
Pages
e01776
ISSN
2326-3253
DOI
10.14309/crj.0000000000001776
PMC
PMC12321452
Cited by
6
References
10
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (unspecified)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.