Aquaporin-4 and Cognitive Disorders
Open accessAbstract
Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral part of the glymphatic system that cannot be ignored. The CNS has the glymphatic system instead of the conventional lymphatic system. The glymphatic system plays an essential role in the pathophysiological processes of many cognitive disorders. AQP4 shows noteworthy changes in various cognitive disorders and is part of the pathogenesis of these diseases. For this reason, AQP4 has attracted attention as a potential and promising target for regulating and even reversing cognitive dysfunction. This review will summarize the role of AQP4 in the pathophysiological processes of several cognitive disorders as reported in recent studies.
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The complex interaction between cholinergic and other transmitter systems participates in the pathophysiological mechanism of brain electricity slowing and cognitive decline in neurodegenerative diseases.
“Studies have shown that the complex interaction between cholinergic and other transmitter systems participates in the pathophysiological mechanism of brain electricity slowing and cognitive decline in neurodegenerative diseases [42-46].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [46]
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References 79 · Cited by 55
- Authors
- Wang, Y., Huang, C., Guo, Q., & Chu, H.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Guo, Qihao
- Chu, Heling
- Venue
- Aging and disease
- Publisher
- Aging and Disease
- Published
- 2022
- Volume
- 13
- Issue
- 1
- Pages
- 61
- ISSN
- 2152-5250 (ISSN-L)
- PMC
- PMC8782559
- OpenAlex
- W4206964640
- Cited by
- 55
- References
- 79
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 8 · 2023: 13 · 2022: 6
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Aging and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82071472, 81901102)
- Fudan University (HSBY2019004)
- Huashan Hospital
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- aquaporin-4, glymphatic system, cognitive disorders, cognitive impairment, central nervous system, pathogenesis, therapeutic target, aging
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