The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Troponin: the biomarker of choice for the detection of cardiac injury
Open accessAbstract
It has been known for 50 years that transaminase activity increases in patients with acute myocardial infarction. With the development of creatine kinase (CK), biomarkers of cardiac injury began to take a major role in the diagnosis and management of patients with acute cardiovascular disease. In 2000 the European Society of Cardiology and the American College of Cardiology recognized the pivotal role of biomarkers and made elevations in their levels the “cornerstone” of diagnosis of acute myocardial infarction. At that time, they also acknowledged that cardiac troponin I and T had supplanted CK-MB as the analytes of choice for diagnosis. In this review, we discuss the science underlying the use of troponin biomarkers, how to interpret troponin values properly and how to apply these measurements to patients who present with possible cardiovascular disease. Troponin is the biomarker of choice for the detection of cardiac injury. To use it properly, one must understand how sensitive the specific assay being used is for detecting cardiac injury, the fact that elevated troponin levels are highly specific for cardiac injury and some critical issues related to the basic science of the protein and its measurement. In this article, we review the biology of troponin, characteristics of assays that measure serum troponin levels and how to apply these measurements to patients who present with possible cardiovascular disease. We also discuss other clinical situations in which troponin levels may be elevated.
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Self-citationCardiac Troponin T Levels for Risk Stratification in Acute Myocardial Ischemia
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Cited by
Pathobiology of Troponin Elevations
White, H. D. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.029 · Cited by 381
Laverty, H., Benson, C., Cartwright, E., Cross, M., Garland, C., Hammond, T., Holloway, C., McMahon, N., Milligan, J., Park, B., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01255.x · Cited by 363
Top‐down proteomics in health and disease: Challenges and opportunities
Gregorich, Z. R., & Ge, Y. (2014) · PROTEOMICS · doi:10.1002/pmic.201300432 · Cited by 217
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The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform
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Metadata
- Authors
- Babuin, L., & Jaffe, A. S.
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Joule Inc.
- Published
- 2005-11-08
- Volume
- 173
- Issue
- 10
- Pages
- 1191-1202
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- OpenAlex
- W2045161311
- Cited by
- 686
- References
- 152
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- gold
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