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Cited by 32Gestational Diabetes Research and ManagementBirth, Development, and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Intrauterine exposure to diabetes and risk of cardiovascular disease in adolescence and early adulthood: A population-based birth cohort study

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Guillemette, Laetitia, Wicklow, Brandy, Sellers, Elizabeth A.C., Dart, Allison, Shen, Garry X., Dolinsky, Vernon W., Gordon, Joseph W., Jassal, Davinder S. +5 more·2020·Canadian Medical Association Journal
DOI 10.1503/cmaj.190797PMC PMC7532013
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Abstract

BACKGROUND: It is unclear whether intrauterine exposure to maternal diabetes is associated with risk factors for cardiovascular disease and related end points in adulthood. We examined this potential association in a population-based birth cohort followed up to age 35 years. METHODS: = 293 546) and followed until March 2015 in Manitoba, Canada, using registry-based administrative data. The primary exposures were intrauterine exposure to gestational diabetes and type 2 diabetes mellitus. The primary outcome was a composite measure of incident cardiovascular disease events, and the secondary outcome was a composite of risk factors for cardiovascular disease in offspring followed up to age 35 years. RESULTS: The cohort provided 3 628 576 person-years of data (mean age at latest follow-up 20.5 [standard deviation 6.4] years, 49.3% female); 2765 (0.9%) of the offspring experienced a cardiovascular disease end point, and 12 673 (4.3%) experienced a cardiovascular disease risk factor. After propensity score matching, the hazard for cardiovascular disease end points was elevated in offspring exposed to gestational diabetes (adjusted hazard ratio [HR] 1.42, 95% confidence interval [CI] 1.12-1.79) but not type 2 diabetes (adjusted HR 1.40, 95% CI 0.98-2.01). A similar association was observed for cardiovascular disease risk factors (gestational diabetes: adjusted HR 1.92, 95% CI 1.75-2.11; type 2 diabetes: adjusted HR 3.40, 95% CI 3.00-3.85). INTERPRETATION: Intrauterine exposure to maternal diabetes was associated with higher morbidity and risk related to cardiovascular disease among offspring up to 35 years of age.

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Authors
Guillemette, L., Wicklow, B., Sellers, E. A. C., Dart, A., Shen, G. X., Dolinsky, V. W., Gordon, J. W., Jassal, D. S., Nickel, N., Duhamel, T. A., Chateau, D., Prior, H. J., & McGavock, J.
Affiliations
Children's Hospital Research Institute of Manitoba (CA)
ORCID
Venue
Canadian Medical Association Journal
Publisher
CMA Impact Inc.
Published
2020-09-27
Volume
192
Issue
39
Pages
E1104-E1113
ISSN
  • 0820-3946 (ISSN-L)
  • 1488-2329
DOI
10.1503/cmaj.190797
PMC
PMC7532013
OpenAlex
W3087955752
Cited by
32
References
44
Citations by year
2026: 4 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 4
FWCI
2.45
Type
journal article
Language
en
Open access
Locations
  • Canadian Medical Association Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
prenatal exposure, maternal diabetes, gestational diabetes mellitus, type 2 diabetes, cardiovascular disease, cardiovascular risk factors, offspring, adolescence, early adulthood, birth cohort
MeSH terms
Adolescent, Adult, Cardiovascular Diseases, Child, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Male, Manitoba, Pregnancy, Pregnancy in Diabetics, Prenatal Exposure Delayed Effects, Registries, Cohort Studies, Diabetes, Gestational, Young Adult

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