Pregnancy, breastfeeding and the SARS-CoV-2 vaccine: an ethics-based framework for shared decision-making
Open accessAbstract
KEY POINTS In December 2020, the Canadian National Advisory Committee on Immunization recommended that the vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) should not be routinely offered to individuals who are pregnant or breastfeeding until further evidence is available
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mRNA COVID-19 vaccines have shown highly effective immune induction in nonpregnant adults.
“While mRNA vaccines have shown highly effective immune induction in non-pregnant adults, the immunogenicity and reactogenicity of this platform in pregnancy remains unclear.”
From Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study (2021) · cites this paper as [11]
Both EUA-approved COVID-19 vaccines (Pfizer/BioNTech and Moderna) use mRNA to deliver the SARS-CoV-2 Spike antigen to the immune system.
“both of which utilize mRNA to deliver SARS-CoV-2 Spike to educate the immune system 10,11”
From Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study (2021) · cites this paper as [11]
The V2 timepoint reflects full antibody complement, achieved one week after Pfizer/BioNTech and two weeks after Moderna/NIH vaccination.
“The V2 timepoint reflects full antibody complement, achieved one week after Pfizer/BioNTech and two weeks after Moderna/NIH 10,11 .”
From Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study (2021) · cites this paper as [11]
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References 5 · Cited by 24
Research works printed but not linked: 1
- [3]Society for Maternal–Fetal Medicine (SMFM) statement: SARS-CoV-2 vaccination in pregnancy. Washington (D.C.): Society for Maternal Fetal Medicine; 2020: 1– 3. Available: www.smfm.org/publications/339-society-for-maternal-fetal-medicine-smfm-statement-sars-cov-2-vaccination-in-pregnancy (accessed 2020 Dec. 14).
- Authors
- Zipursky, J. S., Greenberg, R. A., Maxwell, C., & Bogler, T.
- Affiliations
- St. Michael's Hospital (CA)
- Corresponding author
- Zipursky, Jonathan S.
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Joule Inc.
- Published
- 2021-01-27
- Volume
- 193
- Issue
- 9
- Pages
- E312-E314
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- PMC
- PMC8034306
- OpenAlex
- W3121297936
- Cited by
- 24
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 7 · 2022: 3 · 2021: 10
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Canadian Medical Association Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
- Keywords
- COVID-19 vaccines, COVID-19 vaccination, pregnancy, breastfeeding, shared decision-making, vaccine ethics, vaccine recommendations
- MeSH terms
- Decision Making, Shared, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Breast Feeding, Canada, Ethics, Medical, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Practice Guidelines as Topic, Risk Assessment
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