Subclinical hypercortisolism in hospitalized patients with type 2 diabetes mellitus
Open accessAbstract
Pre(sub)clinical Cushing's disease is a recently described entity defined by the autonomous secretion of ACTH and the absence of a cushingoid appearance. We screened 77 hospitalized patients with diabetes mellitus for subclinical hypercortisolism and detected pre(sub)clinical Cushing's disease in 2 (2.6%) of them. In both patients, transsphenoidal surgery was performed and a microadenoma was removed. Their metabolic clearance rate of glucose measured by a glucose clamp study, an index of insulin sensitivity, significantly improved after surgery. Our results indicate that screening for subclinical hypercortisolism in diabetic patients might be useful, as surgery improves glucose tolerance and insulin sensitivity.
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The prevalence of previously unsuspected Cushing syndrome in patients with type 2 diabetes ranges from 0% to 9.4%.
“The association between DM and CS has been examined in various studies, which have shown a prevalence of previously unsuspected CS in patients with type DM ranging from % to .% (Table ) (-).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [251]
Taniguchi et al. found a 2.6% prevalence of subclinical hypercortisolism in 77 inpatients with type 2 diabetes using midnight serum cortisol with a cutoff of 5 g/dl.
“In keeping with this, Taniguchi et al. (84) found a 2.6% prevalence of SH in a sample of 77 inpatients with type 2 diabetes.Diagnosis was done by measuring MSeC using a cutoff of 5 g/dl (138 nmol/liter).”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [84]
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References 10 · Cited by 42
- Authors
- TANIGUCHI, T., HAMASAKI, A., & OKAMOTO, M.
- Affiliations
- Otsu Red Cross Hospital (JP)
- Kyoto University (JP)
- ORCID
- HAMASAKI, Akihiro
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 2008
- Volume
- 55
- Issue
- 2
- Pages
- 429-432
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W2026696456
- Cited by
- 42
- References
- 10
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- subclinical hypercortisolism, type 2 diabetes, Cushing's disease, transsphenoidal surgery, glucose tolerance, insulin sensitivity, glucose clamp, hospitalized patients, screening
- MeSH terms
- Aged, Cushing Syndrome, Diabetes Mellitus, Type 2, Female, Glucose, Humans, Hydrocortisone, Inpatients, Insulin Resistance, Male, Mass Screening, Middle Aged
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