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Lung Extracellular Matrix and Fibroblast Function
Open accessAbstract
Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides physical support to tissues and is essential for normal organ function. In the lung, ECM plays an active role in shaping cell behavior both in health and disease by virtue of the contextual clues it imparts to cells. Qualities including dimensionality, molecular composition, and intrinsic stiffness all promote normal function of the lung ECM. Alterations in composition and/or modulation of stiffness of the focally injured or diseased lung ECM microenvironment plays a part in reparative processes performed by fibroblasts. Under conditions of remodeling or in disease states, inhomogeneous stiffening (or softening) of the pathologic ECM may both precede modifications in cell behavior and be a result of disease progression. The ability of ECM to stimulate further ECM production by fibroblasts and drive disease progression has potentially significant implications for mesenchymal stromal cell–based therapies; in the setting of pathologic ECM stiffness or composition, the therapeutic intent of progenitor cells may be subverted. Taken together, current data suggest that lung ECM actively contributes to health and disease; thus, mediators of cell–ECM signaling or factors that influence ECM stiffness may represent viable therapeutic targets in many lung disorders.
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“IPF is a process that is characterized by epithelial cell injury, fibroblast expansion, augmented ECM remodeling, and lung architecture destruction (87, 141).”
From Aging and Lung Disease (2020) · cites this paper as [87]
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Metadata
- Authors
- White, E. S.
- Affiliations
- University of Michigan (US)
- Corresponding author
- White, Eric S.
- ORCID
- White, Eric S.
- Venue
- Annals of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-01
- Volume
- 12
- Issue
- Supplement_1
- Pages
- S30-S33
- ISSN
- 2325-6621 (ISSN-L)
- 2329-6933
- PMC
- PMC4430981
- OpenAlex
- W1970148422
- Cited by
- 231
- References
- 46
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 29 · 2023: 28 · 2022: 23 · 2021: 29 · 2020: 20 · 2019: 16 · 2018: 24 · 2017: 11 · 2016: 8
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the American Thoracic Society (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (U01HL111016, R01HL109118)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- lung extracellular matrix, lung fibroblasts, extracellular matrix stiffness, pulmonary fibrosis, tissue remodeling, lung repair, therapeutic target
- MeSH terms
- Extracellular Matrix, Fibroblasts, Humans, Lung
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