The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Pathogenesis of Chronic Obstructive Pulmonary Disease
Open accessAbstract
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different in susceptible smokers and involves a predominance of CD8+ T lymphocytes, neutrophils, and macrophages. Studies have characterized inflammation in the peripheral airspaces in different stages of disease severity. Two other processes have received considerable research attention. The first is a protease–antiprotease imbalance, which has been linked to the pathogenesis of emphysema. However, the hypothesis of an increased protease burden associated with functional inhibition of antiproteases has been difficult to prove and is now considered an oversimplification. The second process, oxidative stress, has a role in many of the pathogenic processes of chronic obstructive pulmonary disease and may be one mechanism that enhances the inflammatory response. In addition, it has been proposed that the development of emphysema may involve alveolar cell loss through apoptosis. This mechanism may involve the vascular endothelial growth factor pathway and oxidative stress.
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Cites
Celli, B. R., MacNee, W., Agusti, A., Anzueto, A., Berg, B., Buist, A. S., Calverley, P. M. A., Chavannes, N., Dillard, T., Fahy, B., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00014304 · Cited by 4,421
Self-citationThe Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
Hogg, J. C., Chu, F., Utokaparch, S., Woods, R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032158 · Cited by 3,782
The natural history of chronic airflow obstruction.
Fletcher, C., & Peto, R. (1977) · BMJ · doi:10.1136/bmj.1.6077.1645 · Cited by 2,370
Keatings, V. M., Collins, P. D., Scott, D. M., & Barnes, P. J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.2.8564092 · Cited by 1,362
Morrow, J. D., Frei, B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W. E., Oates, J. A., & Roberts, L. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321804 · Cited by 1,339
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
Hogg, J. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16900-6 · Cited by 1,294
Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea
PRYOR, W. A., & STONE, K. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39148.x · Cited by 1,152
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
Kasahara, Y., Tuder, R. M., Taraseviciene-Stewart, L., Le Cras, T. D., Abman, S., Hirth, P. K., Waltenberger, J., & Voelkel, N. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10259 · Cited by 1,112
Site and Nature of Airway Obstruction in Chronic Obstructive Lung Disease
Hogg, J. C., Macklem, P. T., & Thurlbeck, W. M. (1968) · New England Journal of Medicine · doi:10.1056/nejm196806202782501 · Cited by 1,054
CD8 + T-Lymphocytes in Peripheral Airways of Smokers with Chronic Obstructive Pulmonary Disease
SAETTA, M., Di STEFANO, A., TURATO, G., FACCHINI, F. M., CORBINO, L., MAPP, C. E., MAESTRELLI, P., CIACCIA, A., & FABBRI, L. M. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.3.9709027 · Cited by 792
Cited by
Almarshoodi, K., Echevarria, C., Kassem, A., Mahboub, B., Salameh, L., & Ward, C. (2024) · Hospital Pharmacy · doi:10.1177/00185787231209218 · Cited by 8
Metadata
- Authors
- MacNee, W.
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-01
- Volume
- 2
- Issue
- 4
- Pages
- 258-266
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- OpenAlex
- W2140264378
- Cited by
- 448
- References
- 99
- FWCI
- 16.03
- Type
- journal article
- Language
- en
- Open access
- green
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
