Cited by 326Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleepSleep and related disorders

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Pathophysiology of Pediatric Obstructive Sleep Apnea

Open access

Katz, Eliot S., D'Ambrosio, Carolyn M.·2008·Proceedings of the American Thoracic Society

DOI 10.1513/pats.200707-111mgPMC PMC2645256

Open this paper in CoChat — free account

Abstract

Sleep-disordered breathing is a common and serious cause of metabolic, cardiovascular, and neurocognitive morbidity in children. The spectrum of obstructive sleep-disordered breathing ranges from habitual snoring to partial or complete airway obstruction, termed obstructive sleep apnea (OSA). Breathing patterns due to airway narrowing are highly variable, including obstructive cycling, increased respiratory effort, flow limitation, tachypnea, and/or gas exchange abnormalities. As a consequence, sleep homeostasis may be disturbed. Increased upper airway resistance is an essential component of OSA, including any combination of narrowing/retropositioning of the maxilla/mandible and/or adenotonsillar hypertrophy. However, in addition to anatomic factors, the stability of the upper airway is predicated on neuromuscular activation, ventilatory control, and arousal threshold. During sleep, most children with OSA intermittently attain a stable breathing pattern, indicating successful neuromuscular activation. At sleep onset, airway muscle activity is reduced, ventilatory variability increases, and an apneic threshold slightly below eupneic levels is observed in non-REM sleep. Airway collapse is offset by pharyngeal dilator activity in response to hypercapnia and negative lumenal pressure. Ventilatory overshoot results in sudden reduction in airway muscle activation, contributing to obstruction during non-REM sleep. Arousal from sleep exacerbates ventilatory instability and, thus, obstructive cycling. Paroxysmal reductions in pharyngeal dilator activity related to central REM sleep processes likely account for the disproportionate severity of OSA observed during REM sleep. Understanding the pathophysiology of pediatric OSA may permit more precise clinical phenotyping, and therefore improve or target therapies related to anatomy, neuromuscular compensation, ventilatory control, and/or arousal threshold.

Integrity signals

Registry

Crossref · 10.1513/pats.200707-111mg

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Risk Factors for Sleep-disordered Breathing in Children: Associations with Obesity, Race, and Respiratory Problems
Redline, S. S., Tishler, P. V., SCHLUCHTER, M. D., Aylor, J. E., Clark, K., & Graham, G. C. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.5.9809079 · Cited by 1,167
A Cause of Excessive Daytime Sleepiness
Guilleminault, C., Stoohs, R. A., Clerk, A. A., Cetel, M. B., & Maistros, P. (1993) · CHEST Journal · doi:10.1378/chest.104.3.781 · Cited by 897
Snoring, sleep disturbance, and behaviour in 4-5 year olds.
Ali, N. J., Pitson, D., & Stradling, J. R. (1993) · Archives of Disease in Childhood · doi:10.1136/adc.68.3.360 · Cited by 881
Snoring, Apneic Episodes, and Nocturnal Hypoxemia Among Children 6 Months to 6 Years Old
Gíslason, Þ., & Benediktsdóttir, B. (1995) · CHEST Journal · doi:10.1378/chest.107.4.963 · Cited by 560
Neurobehavioral Implications of Habitual Snoring in Children
O'Brien, L. M., Mervis, C. Β., Holbrook, C. R., Bruner, J. L., Klaus, C. J., Rutherford, J., Raffield, T. J., & Gozal, D. (2004) · PEDIATRICS · doi:10.1542/peds.114.1.44 · Cited by 512
Polysomnographic Characteristics in Normal Preschool and Early School-Aged Children
Montgomery‐Downs, H. E., O’Brien, L. M., Gulliver, T. E., & Gozal, D. (2006) · PEDIATRICS · doi:10.1542/peds.2005-1067 · Cited by 489
Normal Polysomnographic Respiratory Values in Children and Adolescents
Uliel‐Sibony, S., Tauman, R., Greenfeld, M., & Sivan, Y. (2004) · CHEST Journal · doi:10.1378/chest.125.3.872 · Cited by 460
Role of Arousals in the Pathogenesis of Obstructive Sleep Apnea
Younes, M. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200307-1023oc · Cited by 456 · cited 1×
“However, arousal may also be considered an adverse epiphenomenon that potentiates obstructive cycling and interferes with sleep homeostasis (75).”
Background
The Male Predisposition to Pharyngeal Collapse: Importance of Airway Length
Malhotra, A., Huang, Y., Fogel, R. B., Pillar, G., Edwards, J. K., Kikinis, R., Loring, S. H., & White, D. P. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2112072 · Cited by 441
Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy
Tauman, R., Gulliver, T. E., Krishna, J., Montgomery-Downs, H. E., O’Brien, L. M., Ivanenko, A., & Gozal, D. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.08.067 · Cited by 438
Pathophysiology of Upper Airway Obstruction: a Developmental Perspective
Arens, R., & Marcus, C. L. (2004) · SLEEP · doi:10.1093/sleep/27.5.997 · Cited by 432
Efficacy of fluticasone nasal spray for pediatric obstructive sleep apnea
Brouillette, R. T., Manoukian, J. J., Ducharme, F. M., Oudjhane, K., Earle, L. G., Ladan, S., & Morielli, A. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.114474 · Cited by 396
Sleep Architecture and Respiratory Disturbances in Children with Obstructive Sleep Apnea
GOH, D. Y. T., GALSTER, P., & MARCUS, C. L. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9908058 · Cited by 378
Thoracic influence on upper airway patency
van de Graaff, W. B. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.5.2124 · Cited by 369
Rapid maxillary expansion in children with obstructive sleep apnea syndrome
Pirelli, P., Saponara, M., & Guilleminault, C. (2004) · SLEEP · doi:10.1093/sleep/27.4.761 · Cited by 361
Magnetic Resonance Imaging of the Upper Airway Structure of Children with Obstructive Sleep Apnea Syndrome
Arens, R., McDonough, J. M., Costarino, A. T., Mahboubi, S., Kier, C., Maislin, G., Schwab, R. J., & Pack, A. I. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.4.2101127 · Cited by 324
Ventilatory Control and Airway Anatomy in Obstructive Sleep Apnea
Wellman, A., Jordan, A. S., Malhotra, A., Fogel, R., Katz, E. S., Schory, K., EDWARDS, J. K., & White, D. P. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200404-510oc · Cited by 317
Self-citation
Leukotriene Modifier Therapy for Mild Sleep-disordered Breathing in Children
Goldbart, A. D., Goldman, J. L., Veling, M. C., & Gozal, D. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1064oc · Cited by 315
A longitudinal study of the growth of the nasopharynx and its contents in normal children
Jeans, W. D., Fernando, D. C. J., Maw, A. R., & Leighton, B. C. (1981) · British Journal of Radiology · doi:10.1259/0007-1285-54-638-117 · Cited by 311
Evaluation of pulmonary function and polysomnography in obese children and adolescents
Marcus, C. L., Curtis, S., Koerner, C., Joffe, A., Serwint, J. R., & Loughlin, G. M. (1996) · Pediatric Pulmonology · doi:10.1002/(sici)1099-0496(199603)21:3 · Cited by 299
Changes in ventilation and chest wall mechanics during sleep in normal adolescents
Tabachnik, E., Muller, N. L., Bryan, A. C., & Levison, H. (1981) · Journal of Applied Physiology · doi:10.1152/jappl.1981.51.3.557 · Cited by 281
Polysomnographic values in children 2–9 years old: Additional data and review of the literature
Traeger, N., Schultz, B., Pollock, A. N., Mason, T. A., Marcus, C. L., & Arens, R. (2005) · Pediatric Pulmonology · doi:10.1002/ppul.20236 · Cited by 280
Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution
Verhulst, S. L., Schrauwen, N., Haentjens, D., Suys, B. E., Rooman, R., Gaal, L. V., Backer, W. A. D., & Desager, K. N. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2006.101089 · Cited by 271
Adult Criteria for Obstructive Sleep Apnea Do Not Identify Children with Serious Obstruction
ROSEN, C. L., D’Andrea, L. A., & Haddad, G. G. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_1.1231 · Cited by 264
Intranasal Steroids and Oral Leukotriene Modifier Therapy in Residual Sleep-Disordered Breathing After Tonsillectomy and Adenoidectomy in Children
Kheirandish, L., Goldbart, A. D., & Gozal, D. (2006) · Pediatrics · doi:10.1542/peds.2005-0795 · Cited by 261
Upper airway collapsibility in children with obstructive sleep apnea syndrome
Marcus, C. L., McColley, S. A., Carroll, J. L., Loughlin, G. M., Smith, P. L., & Schwartz, A. R. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.2.918 · Cited by 255
Outcome of Adenotonsillectomy for Obstructive Sleep Apnea in Obese and Normal‐Weight Children
Mitchell, R. B., & Kelly, J. (2007) · Otolaryngology–Head and Neck Surgery · doi:10.1016/j.otohns.2007.03.028 · Cited by 250
Upper Airway Size Analysis by Magnetic Resonance Imaging of Children with Obstructive Sleep Apnea Syndrome
Arens, R., McDonough, J. M., Corbin, A. M., Rubin, N. K., Carroll, M. E., Pack, A. I., Liu, J., & Udupa, J. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-613oc · Cited by 218
Pulse Transit Time as a Measure of Arousal and Respiratory Effort in Children with Sleep-Disordered Breathing
Katz, E. S., Lutz, J., Black, C., & Marcus, C. L. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000057206.14698.47 · Cited by 215
Self-citation
Arousal pattern following central and obstructive breathing abnormalities in infants and children
McNamara, F., Issa, F. G., & Sullivan, C. E. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.6.2651 · Cited by 212
Polysomnography in obese children with a history of sleep‐associated breathing disorders
Silvestri, J. M., Weese‐Mayer, D. E., Bass, M. T., Kenny, A. S., Hauptman, S. A., & Smok-Pearsall, S. M. (1993) · Pediatric Pulmonology · doi:10.1002/ppul.1950160208 · Cited by 198
The Influence of Lung Volume on Pharyngeal Mechanics, Collapsibility, and Genioglossus Muscle Activation during Sleep
Stanchina, M. L., Malhotra, A., Fogel, R., Trinder, J. C., EDWARDS, J. K., Schory, K., & White, D. P. (2003) · SLEEP · doi:10.1093/sleep/26.7.851 · Cited by 195
Comparison of Static Mechanical Properties of the Passive Pharynx between Normal Children and Children with Sleep-disordered Breathing
Isono, S., Shimada, A., Utsugi, M., Konno, A., & Nishino, T. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9702042 · Cited by 194
Adenotonsillectomy and obstructive sleep apnea in children: A prospective survey
Guilleminault, C., Huang, Y., Glamann, C., Li, K. K., & Chan, A. (2007) · Otolaryngology · doi:10.1016/j.otohns.2006.09.021 · Cited by 193
Changes in dentofacial morphology after adeno-/tonsillectomy in young children with obstructive sleep apnoea--a 5-year follow-up study
Zettergren-Wijk, L. (2006) · European Journal of Orthodontics · doi:10.1093/ejo/cji119 · Cited by 188
Influence of Gender and Age on Upper-Airway Length During Development
Ronen, O., Malhotra, A., & Pillar, G. (2007) · PEDIATRICS · doi:10.1542/peds.2006-3433 · Cited by 171
Upper Airway Dynamic Responses in Children with the Obstructive Sleep Apnea Syndrome
Marcus, C. L., Katz, E. S., Lutz, J., Black, C. A., Galster, P., & Carson, K. A. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000147565.74947.14 · Cited by 168
Self-citation
Upper airway patency in the human infant: influence of airway pressure and posture
Wilson, S. L., Thach, B. T., Brouillette, R. T., & Abu‐Osba, Y. K. (1980) · Journal of Applied Physiology · doi:10.1152/jappl.1980.48.3.500 · Cited by 162
Reduced lung volume during behavioral active sleep in the newborn
Henderson-Smart, D. J., & Read, D. J. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.46.6.1081 · Cited by 152
Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children
Waters, K. A., McBrien, F., Stewart, P., Hinder, M. K., & Wharton, S. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00619.2001 · Cited by 152
Linear Dimensions of the Upper Airway Structure during Development: Assessment by Magnetic Resonance Imaging
Arens, R., McDonough, J. M., Corbin, A. M., Hernandez, M., Maislin, G., Schwab, R. J., & Pack, A. I. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.1.2107140 · Cited by 148
Differential Expression of Cysteinyl Leukotriene Receptors 1 and 2 in Tonsils of Children With Obstructive Sleep Apnea Syndrome or Recurrent Infection
Goldbart, A. D., Goldman, J. L., Li, R. C., Brittian, K. R., Tauman, R., & Gozal, D. (2004) · CHEST Journal · doi:10.1378/chest.126.1.13 · Cited by 147
Breathing obstruction in relation to craniofacial and dental arch morphology in 4-year-old children
Löfstrand-Tideström, B. (1999) · European Journal of Orthodontics · doi:10.1093/ejo/21.4.323 · Cited by 146
Arousal and ventilatory responses during sleep in children with obstructive sleep apnea
Marcus, C. L., Lutz, J., Carroll, J. L., & Bamford, O. S. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.6.1926 · Cited by 140
The influence of tonsillar obstruction and tonsillectomy on facial growth and dental arch morphology
Hultcrantz, E., Larson, M., Hellquist, R., Ahlqvist-Rastad, J., Svanholm, H., & Jakobsson, O. P. (1991) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/0165-5876(91)90032-7 · Cited by 130
Reference values for sleep‐related respiratory variables in asymptomatic European children and adolescents
Verhulst, S. L., Schrauwen, N., Haentjens, D., Gaal, L. V., Backer, W. A. D., & Desager, K. (2006) · Pediatric Pulmonology · doi:10.1002/ppul.20551 · Cited by 130
Sleep Pressure Score: a New Index of Sleep Disruption in Snoring Children
Tauman, R., O'Brien, L. M., Holbrook, C. R., & Gozal, D. (2004) · SLEEP · doi:10.1093/sleep/27.2.274 · Cited by 126
Upper Airway Motion Depicted at Cine MR Imaging Performed during Sleep: Comparison between Young Patients with and Those without Obstructive Sleep Apnea
Donnelly, L. F., Surdulescu, V., Chini, B. A., Casper, K. A., Poe, S. A., & Amin, R. S. (2003) · Radiology · doi:10.1148/radiol.2271020198 · Cited by 125
Sleep-disordered breathing, pharyngeal size and soft tissue anatomy in children
Fregosi, R. F., Quan, S. F., Kaemingk, K. L., Morgan, W. J., Goodwin, J. L., Cabrera, R., & Gmitro, A. F. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00293.2003 · Cited by 123
Genioglossus Activity During Sleep in Normal Control Subjects and Children with Obstructive Sleep Apnea
Katz, E. S., & White, D. P. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200403-262oc · Cited by 119
Self-citation
Cranio-facial morphology in children with and without enlarged tonsils
Behlfelt, K., Linder-Aronson, S., McWilliam, J., Neander, P., & Laage-Hellman, J.-E. (1990) · European Journal of Orthodontics · doi:10.1093/ejo/12.3.233 · Cited by 116
Increased Upper Airway Collapsibility in Children with Obstructive Sleep Apnea during Wakefulness
Gozal, D., & Burnside, M. M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-590oc · Cited by 113
Determinants of Lung Volume in Spontaneously Breathing Preterm Infants
Poets, C., Rau, G. A., Neuber, K., Gappa, M., & Seidenberg, J. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032208 · Cited by 113
Measurement of the CO2apneic threshold in newborn infants: possible relevance for periodic breathing and apnea
Khan, A., Qurashi, M., Kwiatkowski, K., Cates, D., & Rigatto, H. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00574.2003 · Cited by 109
Effect of Lateral Positioning on Upper Airway Size and Morphology in Sedated Children
Litman, R. S., Wake, N., Chan, L.-M. L., McDonough, J. M., Sin, S., Mahboubi, S., & Arens, R. (2005) · Anesthesiology · doi:10.1097/00000542-200509000-00009 · Cited by 107
Changes in Upper Airway Size during Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome
Arens, R., Sin, S., McDonough, J. M., Palmer, J. M., Dominguez, T. E., Meyer, H., Wootton, D. M., & Pack, A. I. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200411-1597oc · Cited by 106
A Prospective Study on the Surgical Outcomes of Children with Sleep-Disordered Breathing
Guilleminault, C., Li, K. K., Quo, S. D., & Inouye, R. N. (2004) · SLEEP · doi:10.1093/sleep/27.1.95 · Cited by 100
Predictors of Sleep-Disordered Breathing in Children with a History of Tonsillectomy and/or Adenoidectomy
Morton, S., Rosen, C., Larkin, E. K., Tishler, P. V., Aylor, J. E., & Redline, S. S. (2001) · SLEEP · doi:10.1093/sleep/24.7.823 · Cited by 98
Developmental changes in upper airway dynamics
Marcus, C. L., do Prado, L. B. F., Lutz, J., Katz, E. S., Black, C. A., Galster, P., & Carson, K. A. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00462.2003 · Cited by 98
Self-citation
Correlates of Respiratory Cycle-Related EEG Changes in Children with Sleep-Disordered Breathing
Chervin, R. D., Burns, J. W., Subotic, N. S., Roussi, C., Thelen, B. J., & Ruzicka, D. L. (2004) · SLEEP · doi:10.1093/sleep/27.1.116 · Cited by 98
Children with Nocturnal Upper Airway Obstruction: Postoperative Orthodontic and Respiratory Improvement
K. Ågren, B. N. (1998) · Acta Oto-Laryngologica · doi:10.1080/00016489850154766 · Cited by 97
Cephalometric Comparisons of Craniofacial and Upper Airway Structures in Young Children with Obstructive Sleep Apnea Syndrome
Kawashima, S., Niikuni, N., Chia-hung, L., Takahasi, Y., Kohno, M., Nakajima, I., Akasaka, M., Sakata, H., & Akashi, S. (2000) · Ear Nose & Throat Journal · doi:10.1177/014556130007900708 · Cited by 94
Evidence for persistence of upper airway narrowing during sleep, 12 years after adenotonsillectomy
Tasker, C. (2002) · Archives of Disease in Childhood · doi:10.1136/adc.86.1.34 · Cited by 90
Response to inspiratory resistive loading during sleep in normal children and children with obstructive apnea
Marcus, C. L., Moreira, G. A., Bamford, O. S., & Lutz, J. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.4.1448 · Cited by 88
Chronic Snoring and Sleep in Children: A Demonstration of Sleep Disruption
Lopes, M. C., & Guilleminault, C. (2006) · PEDIATRICS · doi:10.1542/peds.2005-3046 · Cited by 83
Craniofacial differences according to AHI scores of children with obstructive sleep apnoea syndrome: cephalometric study in 39 patients
Toma�, N., Kart, L., Uzun, L., Davşancı, H., G�ndogdu, S., �zdemir, H., Altın, R., S�g�t, A., �inar, F., & Mahmutyazıcıoğlu, K. (2004) · Pediatric Radiology · doi:10.1007/s00247-004-1168-x · Cited by 79
Utility of Noninvasive Pharyngometry in Epidemiologic Studies of Childhood Sleep-disordered Breathing
Monahan, K. J., Larkin, E. K., ROSEN, C. L., Graham, G. C., & Redline, S. S. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200111-061oc · Cited by 77
Breathing Patterns in Prepubertal Children With Sleep-Related Breathing Disorders
Guilleminault, C., Li, K. K., Khramtsov, A., Palombini, L., & Pelayo, R. (2004) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.158.2.153 · Cited by 73
Genioglossus Activity in Children with Obstructive Sleep Apnea during Wakefulness and Sleep Onset
Katz, E. S., & White, D. P. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200301-092oc · Cited by 73
Self-citation
Reduced NREM Sleep Instability in Children with Sleep Disordered Breathing
Gozal, D., Miano, S., Bruni, O., Ferri, R., Pagani, J., Villa, M. P., & Gozal, D. (2007) · SLEEP · doi:10.1093/sleep/30.4.450 · Cited by 70
Snoring, sleep disturbance, and behavior in 4-5 year olds.
Holmes, H. A. (1993) · Archives of Disease in Childhood · doi:10.1136/adc.69.2.265-a · Cited by 64
Ventilatory Responses During Wakefulness In Children With Obstructive Sleep Apnea
Marcus, C. L., Gozal, D., Arens, R., Basinski, D. J., Omlin, K. J., Keens, T. G., & Ward, S. L. D. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.3.8118641 · Cited by 62
Correlation on Cine MR Imaging of Size of Adenoid and Palatine Tonsils with Degree of Upper Airway Motion in Asymptomatic Sedated Children
Donnelly, L. F., Casper, K. A., & Chen, B. (2002) · American Journal of Roentgenology · doi:10.2214/ajr.179.2.1790503 · Cited by 58
Nasal resistances are useful in identifying children with severe obstructive sleep apnea before polysomnography
Rizzi, M., Onorato, J., Andreoli, A., Colombo, S., Pecis, M., Marchisio, P., Morelli, M., Principi, N., Esposito, S., & Sergi, M. (2002) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/s0165-5876(02)00119-2 · Cited by 57
Influence of Airway Pressure on Genioglossus Activity during Sleep in Normal Children
Katz, E. S., Marcus, C. L., & White, D. P. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1450oc · Cited by 55
Self-citation
Nocturnal body position in sleeping children with and without obstructive sleep apnea
Dayyat, E. A., Maarafeya, M. M. A., Capdevila, Ó. S., Kheirandish‐Gozal, L., Montgomery‐Downs, H. E., & Gozal, D. (2007) · Pediatric Pulmonology · doi:10.1002/ppul.20590 · Cited by 44
Ventilatory response to consecutive short hypercapnic challenges in children with obstructive sleep apnea
Gozal, D., Arens, R., Omlin, K. J., Ben‐Ari, J., Aljadeff, G., Harper, R. M., & Keens, T. G. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.5.1608 · Cited by 43
The Endoscopically Measured Effects of Airway Maneuvers and the Lateral Position on Airway Patency in Anesthetized Children with Adenotonsillar Hypertrophy
Arai, Y.-C. P., Fukunaga, K., Ueda, W., Hamada, M., Ikenaga, H., & Fukushima, K. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000148126.53015.f9 · Cited by 40
Mixed and obstructive apneas are related to ventilatory oscillations in premature infants
Waggener, T. B., Frantz, I. D., Cohlan, B. A., & Stark, A. R. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.6.2818 · Cited by 28
Cortical Processing of Respiratory Afferent Stimuli during Sleep in Children with the Obstructive Sleep Apnea Syndrome
Huang, J., Colrain, I. M., Melendres, M. C., Karamessinis, L. R., Pepe, M. E., Samuel, J. M., Abi-Raad, R. F., Trescher, W. H., & Marcus, C. L. (2008) · SLEEP · doi:10.1093/sleep/31.3.403 · Cited by 25
Acoustic arousal responses in children with obstructive sleep apnea
Moreira, G. A., Tufik, S. B., Nery, L. E., Lutz, J., Verfaille, K., Luan, X., & Marcus, C. L. (2005) · Pediatric Pulmonology · doi:10.1002/ppul.20219 · Cited by 24
Inhalation of low (0.5%–1.5%) CO2 as a potential treatment for apnea of prematurity
Alsaif, S. A., Alvaro, R. E., Manfreda, J., Kwiatkowski, K., Cates, D., & Rigatto, H. (2001) · Seminars in Perinatology · doi:10.1053/sper.2001.23199 · Cited by 20
Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children
Fregosi, R. F., Quan, S. F., Jackson, A. C., Kaemingk, K. L., Morgan, W. J., Goodwin, J., Reeder, J. C., Cabrera, R., & Antonio, E. (2004) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-4-4 · Cited by 18
Adenotonsillectomy and obstructive sleep apnea in children: A prospective survey
Gapany, M. (2008) · Yearbook of Otolaryngology-Head and Neck Surgery · doi:10.1016/s1041-892x(08)79167-4 · Cited by 18
Histological analysis of palatopharyngeal muscle from children with snoring and obstructive sleep apnea syndrome
de Vuono, I. M., Zanoteli, E., Oliveira, A. S. B., Fujita, R. R., Pignatari, S. S. N., Pizarro, G. U., Pradelle-Hallinan, M. L. D. C., & Moreira, G. A. (2006) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2006.10.019 · Cited by 16
Pharyngeal critical pressure in children with mild sleep-disordered breathing
Fregosi, R. F., Quan, S. F., Morgan, W. L., Goodwin, J. L., Cabrera, R., Shareif, I., Fridel, K. W., & Bootzin, R. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01444.2005 · Cited by 13
Obstructive sleep apnea: Children versus adults
Katz, E. S., & Marcus, C. L. (2011) · Informa Healthcare eBooks · doi:10.3109/9781420020885.019 · Cited by 1
Self-citation

Research works printed but not linked: 16

1981, J Appl Phys, 51, 557
2004, Sleep, 27, 95
2003, J Appl Phys, 95, 2030
2007, Sleep, 30, A68
2007, Sleep, 30, A67
1980, J Appl Phys, 48, 500
1994, J Appl Phys, 77, 918
2006, Am J Respir Crit Care Med, 173, A734
2004, J Appl Phys, 97, 98
1998, J Appl Phys, 84, 1926
1979, J Appl Phys, 46, 1081
1988, J Appl Phys, 65, 2124
1999, J Appl Phys, 87, 1448
2005, J Appl Phys, 98, 1171
1989, J Appl Phys, 66, 2818
2002, J Appl Phys, 92, 1987, 10.1063/1.1494127 · DOI

Sorted by citations

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management
Kaditis, A. G., Álvarez, M. L. A., Boudewyns, A. N., Alexopoulos, E. Ι., Ersu, R. H., Joosten, K., Larramona, H., Miano, S., Narang, I., Trang, H., et al. (2015) · European Respiratory Journal · doi:10.1183/13993003.00385-2015 · Cited by 944
A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service
Kuan, V., Denaxas, S., Gonzalez-Izquierdo, A., Direk, K., Bhatti, O., Husain, S., Sutaria, S., Hingorani, M., Nitsch, D., Parisinos, C. A., et al. (2019) · The Lancet Digital Health · doi:10.1016/s2589-7500(19)30012-3 · Cited by 305
Obstructive Sleep Apnea in Children
Dayyat, E., Kheirandish-Gozal, L., Sans Capdevila, O., Maarafeya, M. M. A., & Gozal, D. (2009) · Chest · doi:10.1378/chest.08-2568 · Cited by 260
Childhood Obesity and Obstructive Sleep Apnea
Narang, I., & Mathew, J. L. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/134202 · Cited by 284
Risk Factors for Obstructive Sleep Apnea Syndrome in Children: State of the Art
Gulotta, G., Iannella, G., Vicini, C., Polimeni, A., Greco, A., VINCENTIIS, M. D., Visconti, I. C., Meccariello, G., Cammaroto, G., Vito, A. D., et al. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16183235 · Cited by 223

See all 326

Authors: Katz, E. S., & D'Ambrosio, C. M.
Affiliations: Boston Children's Hospital (US)
Division of Pulmonary Diseases, Department of Medicine, Tufts-New England Medical Center, and Tufts Medical School, Boston, Massachusetts
ORCID: Katz, Eliot S.
Venue: Proceedings of the American Thoracic Society
Publisher: Oxford University Press (OUP)
Published: 2008-02
Volume: 5
Issue: 2
Pages: 253-262
ISSN: 1546-3222 (ISSN-L)
1943-5665
DOI: 10.1513/pats.200707-111mg
PMC: PMC2645256
OpenAlex: W2054680308
Cited by: 326
References: 87
Citations by year: 2026: 14 · 2025: 23 · 2024: 23 · 2023: 26 · 2022: 21 · 2021: 29 · 2020: 28 · 2019: 19 · 2018: 10 · 2017: 17 · 2016: 12 · 2015: 17 · 2014: 15 · 2013: 13 · 2012: 18
FWCI: 1.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Proceedings of the American Thoracic Society (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL073238, K23HL073238)
National Center for Research Resources (M01-RR02172, M01RR002172, RR02172)
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: pediatric obstructive sleep apnea, sleep-disordered breathing, upper airway resistance, airway collapse, ventilation control, arousal threshold, REM sleep, NREM sleep, adenotonsillar hypertrophy, neuromuscular activation, sleep homeostasis, snoring
MeSH terms: Child, Electromyography, Humans, Obesity, Pharynx, Risk Factors, Snoring, Craniofacial Abnormalities, Sleep Apnea, Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pathophysiology of Pediatric Obstructive Sleep Apnea

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks