The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The large-scale organization of metabolic networks
Abstract
Abstract In a cell or microorganism, the processes that generate mass, energy, information transfer and cell-fate specification are seamlessly integrated through a complex network of cellular constituents and reactions1. However, despite the key role of these networks in sustaining cellular functions, their large-scale structure is essentially unknown. Here we present a systematic comparative mathematical analysis of the metabolic networks of 43 organisms representing all three domains of life. We show that, despite significant variation in their individual constituents and pathways, these metabolic networks have the same topological scaling properties and show striking similarities to the inherent organization of complex non-biological systems2. This may indicate that metabolic organization is not only identical for all living organisms, but also complies with the design principles of robust and error-tolerant scale-free networks2, 3, 4, 5, and may represent a common blueprint for the large-scale organization of interactions among all cellular constituents.
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Citations
Cites
Emergence of Scaling in Random Networks
Barabási, A.-L., & Albert, R. (1999) · Science · doi:10.1126/science.286.5439.509 · Cited by 36,135
Self-citationFrom molecular to modular cell biology.
Hartwell, L. H., Hopfield, J. J., Leibler, S., & Murray, A. W. (1999) · Nature · doi:10.1038/35011540 · Cited by 3,632
The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms
West, G. B., Brown, J. H., & Enquist, B. J. (1999) · Science · doi:10.1126/science.284.5420.1677 · Cited by 1,718
Cited by
Network biology: understanding the cell's functional organization
Barabási, A.-L., & Oltvai, Z. N. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1272 · Cited by 7,903
Self-citationA General Framework for Weighted Gene Co-Expression Network Analysis
Zhang, B., & Horvath, S. (2005) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1128 · Cited by 5,684
Computational systems biology.
Kitano, H. (2002) · Nature · doi:10.1038/nature01254 · Cited by 2,209
Metabolic network structure determines key aspects of functionality and regulation
Stelling, J., Klamt, S., Bettenbrock, K., Schuster, S., & Gilles, E. D. (2002) · Nature · doi:10.1038/nature01166 · Cited by 802
Chesler, E. J., Lu, L., Shou, S., Qu, Y., Gu, J., Wang, J., Hsu, H. C., Mountz, J. D., Baldwin, N. E., Langston, M. A., et al. (2005) · Nature Genetics · doi:10.1038/ng1518 · Cited by 719
Metadata
- Authors
- Jeong, H., Tombort, B., Albert, R., Oltvai, L. N., & Barabási, A.-L.
- Venue
- The Structure and Dynamics of Networks
- Publisher
- Princeton University Press
- Published
- 2011-12-31
- Pages
- 211-214
- OpenAlex
- W2921811239
- Cited by
- 279
- References
- 3
- FWCI
- 5.81
- Type
- book chapter
- Language
- en
- Open access
- closed
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- Jeong, H., Tombort, B., Albert, R., Oltvai, L. N., & Barabási, A.-L. (2011). The large-scale organization of metabolic networks. The Structure and Dynamics of Networks. https://doi.org/10.1515/9781400841356.211
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