The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome
Open accessAbstract
Gap junctions are clustered channels between contacting cells through which direct intercellular communication via diffusion of ions and metabolites can occur. Two hemichannels, each built up of six connexin protein subunits in the plasma membrane of adjacent cells, can dock to each other to form conduits between cells. We have recently screened mouse and human genomic data bases and have found 19 connexin (Cx) genes in the mouse genome and 20 connexin genes in the human genome. One mouse connexin gene and two human connexin genes do not appear to have orthologs in the other genome. With three exceptions, the characterized connexin genes comprise two exons whereby the complete reading frame is located on the second exon. Targeted ablation of eleven mouse connexin genes revealed basic insights into the functional diversity of the connexin gene family. In addition, the phenotypes of human genetic disorders caused by mutated connexin genes further complement our understanding of connexin functions in the human organism. In this review we compare currently identified connexin genes in both the mouse and human genome and discuss the functions of gap junctions deduced from targeted mouse mutants and human genetic disorders.
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Citations
Cites
Impaired Electrical Signaling Disrupts Gamma Frequency Oscillations in Connexin 36-Deficient Mice
Hormuzdi, S. G., Pais, I., LeBeau, F. E. N., Towers, S. K., Rozov, A., Buhl, E. H., Whittington, M. A., & Monyer, H. (2001) · Neuron · doi:10.1016/s0896-6273(01)00387-7 · Cited by 522
Impaired conduction of vasodilation along arterioles in connexin40-deficient mice
de Wit, C., Roos, F., Bolz, S.-S., Kirchhoff, S., Krüger, O., Willecke, K., & Pohl, U. (2000) · Circulation Research · doi:10.1161/01.res.86.6.649 · Cited by 338
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Cited by
Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias
KLÉBER, A. G., & RUDY, Y. (2004) · Physiological Reviews · doi:10.1152/physrev.00025.2003 · Cited by 1,083
Gap junctions and the connexin protein family
SOHL, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.013 · Cited by 991
ELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN
Connors, B. W., & Long, M. A. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131128 · Cited by 784
Update on connexins and gap junctions in neurons and glia in the mammalian nervous system
Nagy, J. I., Dudek, F. E., & Rash, J. E. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.005 · Cited by 375
Potent block of Cx36 and Cx50 gap junction channels by mefloquine
Cruikshank, S. J., Hopperstad, M., Younger, M., Connors, B. W., Spray, D. C., & Srinivas, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402044101 · Cited by 350
Metadata
- Authors
- Willecke, K., Eiberger, J., Degen, J., Eckardt, D., Romualdi, A., Güldenagel, M., Deutsch, U., & Söhl, G.
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2002-01-15
- Volume
- 383
- Issue
- 5
- Pages
- 725-37
- ISSN
- 1431-6730 (ISSN-L)
- OpenAlex
- W2161305913
- Cited by
- 1,158
- References
- 2
- FWCI
- 34.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Willecke, K., Eiberger, J., Degen, J., Eckardt, D., Romualdi, A., Güldenagel, M., Deutsch, U., & Söhl, G. (2002). Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome. Biological Chemistry. https://doi.org/10.1515/bc.2002.076
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